薬物相互作用の薬理学的研究(第4報) : マウス血漿, 脳, 肝臓におけるThiopental濃度におよぼすAdenyl系化合物の影響

抄録

Experiments were undertaken to examine the effect of adenyl compounds (adenosine or adenosine 3'-monophosphate) on the accumulation of thiopental (free base) in the tissues of mice, and following results were obtained. 1) In mouse liver and blood, there was no difference in the accumulation of thiopental between the groups pretreated with adenyl compounds (subcutaneous injection) and those treated with a vehicle. 2) Immediatly after the administration of thiopental sodium (intraperitoneal injection), accumulation of thiopental in the brain did not differ between these two groups. However, the concentration of brain thiopental in the groups pretreated with adenyl compounds showed a 2-fold increase after 2 hr and a 10-fold change after 4 hr compared with that in the vehicle-treated groups. From these results, a better correlation was found between the prolongation effect of thiopental accumulation time in the brain and that of thiopental sodium sleeping time by the use of adenyl compounds.