抄録
Absorption of indomethacin from the rabbit rectum was examined in comparison with the suppositories containing indomethacin polymorphs (α- or γ-form). Rectal suppositories were made with Witepsol H12. Plasma levels of α-form indomethacin was higher than that of γ-form. The commercial product (Inteban suppository) made with polyethylene glycol (PEG) base was also examined. Plasma level of Inteban was similar to that of α-form. The relationship between the thermodynamic activities of indomethacin polymorphs and their rectal absorption was discussed.
