Annals of Cancer Research and Therapy
Online ISSN : 1880-5469
Print ISSN : 1344-6835
ISSN-L : 1344-6835
Volume 14 , Issue 2
Showing 1-2 articles out of 2 articles from the selected issue
Original Articles
  • Tsuyoshi Shigehisa, Hiroshi Honda
    2006 Volume 14 Issue 2 Pages 28-38
    Published: 2006
    Released: December 27, 2006
    Background In an attempt to investigate impact of psychological parameters on cancer morbidity, personality and quality of life (QOL) data were obtained before, and immunological data before and after, the onset of intervention.
    Method Personality was assessed with the EPQ-25, STAXI, RED and NH scales, and QOL with QOL-20.
    Results Number of NK cells, T4 and T8 lymphocytes and rate of lymphocyte proliferation (PHA responsiveness) significantly increased after (but not before) the intervention onset. Except NK cells, they increased in low neuroticism and high lie/dissimulation, anger-suppression or emotional-defensiveness scorers (repressors). An increase in T4/T8 ratio was greater in repressors. NK cells increased regardless of personality, if age was disregarded. Further, T lymphocytes increased in high (better) physical (B), psychological (P) and B/P QOL scorers, and in patients advanced in age or TNM stage. Low neuroticism and high anger-suppression scores predicted lesser number of lymphocytes before, and low neuroticism score predicted greater increase in lymphocytes after, the onset of intervention. Increase in NK cells was greater in low neuroticism or high anger-suppression scorers for younger patients, and this relationship was reversed for older patients.
    Coclusion Cancer patients’ immunological status varies with personality, QOL and psychological intervention, in relation to age and TNM stage.
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  • Tsuyoshi Shigehisa, Hiroshi Honda
    2006 Volume 14 Issue 2 Pages 39-47
    Published: 2006
    Released: December 27, 2006
    Background Recent improvement in treatment of patients with cancer caused longer survival but also an increase in the number of patients at risk of developing anemia and impaired quality of life (QOL). Previous studies found that personality confers an increased risk of cancer morbidity related to immunological status, unless patients receive paychological care or intervention.
    Method This study examined anemia-related morbidity by comparing patients’ subjective reports of QOL using the QOL-20 subscales (correlated with hemoglobin levels before and after surgery or chemotherapy) among 16 personality types on the Eysenck Personality Questionnaire, the EPQ-25.
    Results Differences were accounted for by the trait of neuroticism (N+) in conjunction with introversion (E−), vulnerability or softmindedness (P−) and lack of repression or social-naivety (L−), providing evidence for three personality types, intolerant (E−N+P−), melancholic (E−N+) and high-anxious (N+L−), as potential risk factors of developing anemia-related morbidity or QOL deficits. These personality types were predictive of anemia-related cancer morbidity, independent of tumor site, TNM stage, age and sex. Sensitivity for the prediction was 90.6% (intolerant type), 87.2% (melancholic type) or 62.2% (high-anxious type).
    Coclusion The evidence of these personality types provides insight into the strategy for the patient selection and stratification for prophylactic treatment, of debility or anemia and related morbidity, by preoperative patient care and support or intervention as well as recombinant human erythropoietin, improving the QOL and anemia-related morbidity.

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