Annals of Cancer Research and Therapy
Online ISSN : 1880-5469
Print ISSN : 1344-6835
ISSN-L : 1344-6835
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Showing 1-5 articles out of 5 articles from the selected issue
  • Yusupbekov A. Akhmedjanovich, Michitaka Honda, Juraev E. Ergashbayevic ...
    Type: case-report
    2020 Volume 28 Issue 2 Pages 49-53
    Published: July 09, 2020
    Released: July 09, 2020
    JOURNALS FREE ACCESS

    Esophageal leiomyosarcoma (ELMS) is a rare tumor of mesenchymal origin that develops from the smooth muscles of the esophagus. ELMS is typically located in the lower third of the esophagus. We herein report a patient who underwent surgical resection for ELMS, 80 mm in diameter, in the upper third of the esophagus. A 58-year-old man experienced difficulty swallowing, and his swallowing function gradually deteriorated about 6 months before admission. McCeowns operation, which is a kind of esophagectomy performed via the thoraco-laparo-cervicotomy approach, was conducted. The postoperative course was good, without complications, and he was discharged on postoperative day 13. A pathological examination revealed highly differentiated ELMS.

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  • Mazen Almehmadi, Khalid Alzahrani, Magdi M. Salih, Abdulaziz Alsharif ...
    2020 Volume 28 Issue 2 Pages 54-59
    Published: July 09, 2020
    Released: July 09, 2020
    JOURNALS FREE ACCESS

    Background: Vitamin D roles in human health and wellbeing have been extensively studied in the recent years. It has essential roles in homeostasis and maintaining many physiological functions. These roles are vital in immune system, respiratory system, cardiovascular system, and reproductive system. Deficiency in this vitamin has been correlated with many diseases in the body, and it has been correlated with developing cancer.

    Objective: This study aimed to investigate levels of total vitamin D (25-hydroxycholecalciferol) in cancer patients.

    Design: Retrospective.

    Settings: Taif city- king Faisal Hospital (KFH).

    Patients and methods: Serum levels of 25-hydroxycholecalciferol were classified into normal, insufficient, and deficiency group, patients were grouped according to these classes.156 patients were included in this study, 128 females and 28 males, 100 healthy participants were included. Cancer patients were as follows, gastrointestinal tract cancer patients were 27, breast cancer patients were 73, female genital tract patients were 43, head and neck cancer patients were 6 and respiratory tract patients were 7.

    Sample size: 256 participants were 100 healthy controls and 156 cancer patients.

    Results: Deficiency was detected in most of the patients from both genders, and in both pre- and post-menopausal female patients.

    Conclusion: These findings support the belief that deficiency in vitamin D is a risk factor leading to development of cancer.

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  • Hiroaki Shidei, Teppei Kono, Rie Imaizumi, Taro Koike, Hideyuki Yokoka ...
    Type: case-report
    2020 Volume 28 Issue 2 Pages 60-62
    Published: July 09, 2020
    Released: July 14, 2020
    JOURNALS FREE ACCESS

    Low-grade appendiceal mucinous neoplasm (LAMN) is a rare disease. The strategy of treatment for LAMN has not been established. We herein present a case of LAMN treated by laparoscopic ileocecal resection with D2 lymph node (LN) dissection, which exhibited invagination. A 59-year-old man visited at our emergency room with intermittent abdominal pain. Abdomino-pelvic computed tomography (CT) revealed suspiciously a diagnosis as intussusception of LAMN into the ascending colon. Emergency laparoscopic operation was performed. A laparoscopic ileocecal resection with D2 LN dissection was performed because swollen lymph nodes were notified around the ileocolic artery. Histologically, he was diagnosed as LAMN, T3, N0, M0, Stage II.

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  • Mazen Almehmadi
    2020 Volume 28 Issue 2 Pages 63-70
    Published: July 09, 2020
    Released: July 21, 2020
    JOURNALS FREE ACCESS

    Background: Liver function test (LFT) is a routine laboratory examination used in the diagnosis of many disorders, the liver participates in several essential functions in the human body, and liver dysfunction can lead to morbidity and mortality. Therefore, studying the levels of LFT in untreated cancer patients can identify how the liver perform when cancer begins, and which parameter of LFT is affected early.

    Objective: This study aimed to evaluate levels of LFT including alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), albumin, total bilirubin (T bilirubin), direct bilirubin (D bilirubin), and total protein (T protein), in untreated cancer patients.

    Design: Cross-sectional retrospective.

    Settings: Taif city- king Faisal Hospital (KFH) and Taif university.

    Patients and methods: Serum levels of ALT, AST, ALP, T protein, T bilirubin, D bilirubin, and albumin were evaluated. 256 Participants were included in this study and 30 were healthy participants. Cancer patients were as follows, gastrointestinal tract cancer patients were 59, breast cancer patients were 45, gynecological tumors were 50, head and neck cancer patients were 20, blood tumor patients were 28, and urogenital tract patients were 24. Statistical analysis applied were T-test, Chi-square, odds ratio, and relative risk.

    Sample size: 256 participants were 30 healthy controls and 226 untreated cancer patients.

    Results: Hypoproteinemia was highly detected as 44% of patients demonstrated hypoalbuminemia and 22.2% of patients have low levels in T protein. AST, ALT, and ALP showed significant increase in patients than healthy control.

    Conclusion: Hypoproteinemia can be used as a prognostic marker of liver dysfunction in untreated cancer patients.

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  • Mahsa Mohseni, Morteza Arab-Zozani, Ayat Ahmadi, Babak Salimi, Ali Akb ...
    2020 Volume 28 Issue 2 Pages 71-80
    Published: July 09, 2020
    Released: August 11, 2020
    JOURNALS FREE ACCESS

    Introduction: Neutropenia is a major common complication in patients who are treated with myelosuppressive chemotherapy. Prophylaxis with granulocyte colony-stimulating factors (G-CSFs) has been used to reduce the incidence, duration, and severity of chemotherapy-induced neutropenia (CIN).

    Methods: This study aimed to examine the efficacy and safety of pegfilgrastim compared with filgrastim in treating chemotherapy-induced febrile neutropenia. PubMed/MEDLINE, Cochrane Library, Scopus, Embase, and Web of science were searched until December 2015. The search was updated in January 2018. Also, the reference lists of included studies were screened for additional citations. The quality of studies was evaluated using the Cochrane risk of bias tools and the random effect model was applied for analyzing the result.

    Results: Eleven studies with 1,578 participants (799 in pegfilgrastim arm and 779 in filgrastim arm) fulfilled the inclusion criteria. The incidence of grade 4 neutropenia and febrile neutropenia, the duration of grade 4 neutropenia, and recovery of the absolute neutrophil count were slightly reduced in the pegfilgrastim group, though this difference was not statistically significant. For bone pain, despite the observed superiority in the pegfilgrastim group, there was no significant difference between the two drugs.

    Conclusion: The results of our review suggest that there is no overall treatment benefit for a median 10–14 days of filgrastim compared to a single dose of pegfilgrastim in the incidence of grade 4 neutropenia, incidence of febrile neutropenia, duration of grade 4 neutropenia, and recovery of absolute neutrophil count and bone pain in the treatment of CIN.

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