Makamycin is a member of a group of antibiotics including streptogramin1,17), PA 1142,18) staphylomycin3,19), and ostreogricin (E 129)4,20), and was isolated from a cultured material of Streptomyces mitakaensis in our laboratory5). Later two mikamycins, mikamycins A and B, were extracted and purified, and their strong synergistic relation was reported 6). Structures of these two mikamycins were studied and they were confirmed to be quite different each other. Mikamycin B is a cyclic peptide, having lactone linkage and being constituted of 3-hydroxypicolinic acid, L-threonine, L-4-oxopipecolic acid, D-α-aminobutylic acid, L-phenylglycine, L-proline, and L-p-dimethylamino-N-methyl-phenylalanine7,8). The formula of A, C31H39O9N3, and hydrolysis studies by Okabe9) indicated its quite different structure from B. These different structures of A and B suggested their different action mechanisms. It is an interesting problem, whether A and B showing such a strong synergism would inhibit different steps in a same series of metabolism, or they would depress those in different series of metabolism .
In this paper, studies on effects of mikamycins A and B on synthesis of protein and nucleic acids are presented.
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