Endocrine Journal
収録数 6,152本
(更新日 2022/07/05)
Online ISSN : 1348-4540
Print ISSN : 0918-8959
ISSN-L : 0918-8959
2021 Journal Impact Factor (JIF)
ジャーナル 査読 フリー HTML 早期公開
Scopus Pubmed
69 巻 (2022) 6 号 p. 689-703
Effects of a new 75 g glucose- and high fat-containing cookie meal test on postprandial glucose and triglyceride excursions in morbidly obese patients もっと読む

It has been highlighted that postprandial hyperinsulinemia-associated hypoglycemia sometimes happens in patients with morbid obesity after metabolic surgeries. In the present study, Dr. Yukako Yamamoto and her colleague provide a line of convincing data demonstrating that a 75 g glucose- and high fat-containing cookie meal test is useful in severely obese subjects to precisely evaluate glucose intolerance and postprandial dyslipidemia without occurrence of hyperinsulinemia-associated hypoglycemia. The cookie meal test may open a fresh avenue to conveniently monitor fuel homeostasis in the course of multidisciplinary therapies for obese-diabetic patients.

69 巻 (2022) 5 号 p. 547-557
Low plasma renin activity is independently associated with kidney disease progression in patients with type 2 diabetes and overt nephropathy, including those with impaired kidney function: a 2-year prospective study もっと読む

A variety of factors including dysregulation of renin-angiotensin-aldosterone system in both systemically and locally are well known to affect the progression of diabetic nephropathy (DN).To our surprise, however, the possible association between the plasma renin activity (PRA) and renal outcomes in patients with DN still remains obscure. In the present article, Dr. Kazuyoshi Kuma and colleague elegantly addressed such a unsolved question in a 2 year-prospective study, highlighting that low in PRA is an independent risk for the progression of DN in a Japanese cohort.

69 巻 (2022) 4 号 p. 373-383
Burden of disease of X-linked hypophosphatemia in Japanese and Korean patients: a cross-sectional survey もっと読む

X-linked hypophosphatemia (XLH) in known to substantially secrete FGF23, thereby causing renal phosphate loss, chronic hypophosphatemia and a variety of involvement in skeletal system. However, the reality in clinics has not been fully examined. In the present study, via the online questionnaire methods, Ito N et al. comprehensively evaluate the current status and health-related quality of life in patients with XLH living in Japan and Korea, providing us with the latest knowledge and insight into XHL.

69 巻 (2022) 3 号 p. 319-326
DNA methylation level of the gene encoding thioredoxin-interacting protein in peripheral blood cells is associated with metabolic syndrome in the Japanese general population もっと読む

Convincing and conveniently-evaluated molecular biomarkers for prediction and assessment of metabolic syndrome are warranted to realize precision health as well as precision medicine in lifestyle-related diseases. In the present study, Yamazaki M and colleague provide intriguing evidence that level of DNA methylation of the gene encoding thioredoxin-interacting protein, a key inhibitor of cellular oxidation, is significantly decreased in peripheral blood cells from subjects with metabolic syndrome. Further extensive studies are strongly expected to see whether such a status of hypomethylation is clinically relevant to the extent of systemic oxidative stress and would be reversible in response to a line of lifestyle modifications or metabolic surgeries.

69 巻 (2022) 2 号 p. 139-154
Pathological diagnosis of general rules for the description of thyroid cancer by Japanese Society of Thyroid Pathology and Japan Association of Endocrine Surgery もっと読む

In this issue, Kamma H and colleague highlight the update of general rules for the description of thyroid cancer proposed by Japanese Society of Thyroid Pathology and Japan Association of Endocrine Surgery. This article is strongly expected to lay a brand-new cornerstone in transferring Japanese diagnostic standard on thyroid cancer for the world.

月間アクセス数ランキング (2022年06月)