A Template system for the understanding of human CYP2J2-mediated reactions was constructed from the assembly of the ligands with the introduction of ideas of allowable width, Trigger-residue and the residue-initiated movement of ligands in the active site, which were in common with other Template* systems for human CYP1A1, CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2C18, CYP2C19, CYP2E1, CYP3A4, CYP3A5, and CYP3A7 (Drug Metab Pharmacokinet 2016, 2017, 2019, 2020, 2021, 2022, 2023, 2024, and in press 2024). CYP2J2 system also includes ideas of bi-molecule binding of ligands on the Template. From their placements on the Template and rules for interaction modes, verifications of good and poor substrates, regio/stereo-selectivity, and inhibitory interaction became available faithfully for these ligands. The refined CYP2J2-Template system will thus offer reliable estimations of this human CYP catalysis toward ligands of diverse structures, together with their deciphering information to lead to judgments.

Food Safety Commission of Japan (FSCJ) has recently revised the Guideline for the Risk Assessment of the Effects of Food on Health for Foodborne Microorganisms and Others (Viruses, Parasites) and newly issued its supplemental manual as the “Technical Guide for the Risk Assessment of the Effects of Food on Health for Foodborne Microorganisms and Others (Viruses, Parasites)”. These documents are based recent evidence and according to the Microbiological Risk Assessment Guidance for Food, Microbiological Risk Assessment Series 36 published by FAO/WHO. This short review describes the main structures and characteristics of these documents.