The development of Convolutional Neural Networks (CNN) has produced remarkable great contribution to a wide range of image processing fields. On the other hand,there are premised on the existence of a large amount of annotated data. In addition to it, when a model learned in a domain is applied to a different domain, even if in the same task, there is no guarantee of its accuracy. This is a very important issue when deep learning and machine learning are applied in the field. If re-annotation re-learning is performed for data with such a domain difference, the same accuracy can be expected to be maintained again. But, semantic segmentation needs fine annotation and its high labor cost makes its application difficult. Histopathological image segmentation which is expected to drug discovery and medical image analysis is expensive due to its annotation cost, a wide variety of specimen and the need for the skills of histopathological experts. Therefore, the purpose of this research is to reduce the re-annotation cost of data in the new environment using the idea of domain adaptation. In this study, we focus on domain adaptation focusing on the class imbalance problem. The output of the class with few labels tends to be unstable in the class imbalanced data We proposed new cost function which is focusing on the class of few labels with histopathological image. As you can see our result, we achived imporvement of this problem. This made it possible to create a model that suppressed the class imbalance of the dataset in domain adaptation for pathological image segmentation.
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