In the use of radiotherapy for pituitary tumors, high-dose irradiation applied to the pituitary from outside of the focus has been known. Recently, we introduced that instead of using high-dose irradiation, a very low dose radiotherapy emitting chiefly β-ray has been used, inserted directly into the tumor. The radioisotope is inserted and into the tumor via the sphenoid sinus of the nose by puncturing the sella turcica. This therapy has been attempted, we applied this therapy to a 51-year-old woman and 40 male both with chief complaints of headache, disturbed visual acuity and a disturbed visual field, symptoms associated with elevated intracranial pressure. They had transfrontal craniotomy for pituitary tumor in the department of neurosurgery. The patient was subsequently referred to our clinic because the tumor recurred again. The patients responded well to this therapy, the symptoms disappeared after new method and returned to normal life until now. Long follow-up revealed a very good outcome and no recurrence of tumor. This new treatment is easy to apply, safe and effective and is considered to be particularly suitable for elderly or physically weak patients, patients with recurrence after craniotomy, and those who are afraid of surgery.
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