[in Japanese]

View full abstract

[in Japanese]

View full abstract

[in Japanese]

View full abstract

[in Japanese]

View full abstract

[in Japanese]

View full abstract

[in Japanese]

View full abstract

[Aim] Relationship between anthropometric measurements and serum vitamin concentrations has not been established. The aim of this study was to elucidate relationship between anthropometric measurements and serum vitamin concentrations in patients who underwent gastrointestinal surgery.
[Results] Anthropometric measurements decreased significantly after surgery. Serum levels of vitamin A, vitamin B₂, riboflavin, flavin mononucleotide and nicotinic acid decreased after surgery, while vitamin B₁₂ and folic acid increased. Anthropometric measurements significantly correlated to serum vitamin concentrations. In particular, creatinine height index and triceps skin fold correlated well to vitamin B₂, riboflavin and flavin mononucleotide. Values of anthropometric measurements that maintain serum vitamin B₂ concentration within the normal range were estimated as creatinine height index > 77-84% and triceps skin fold > 12-13mm.
[Conclusion] These results suggest that creatinine height index and triceps skin fold potentially reflect serum concentrations of vitamin B₂, riboflavin and flavin mononucleotide.

View full abstract

Purpose: There are some reports that green tea catechin has anti-fibrotic and anti-oxidative effects, but the mechanism has not yet been elucidated in detail. In this stydy, using cholestatic rats with bile duct ligation, we evaluated anti-fibrotic effect of the liver in green tea catechin and elucidated its functional mechanism. Material and Method: Seven weeks old male Wistar rats, we used in the cholestatic state with bile duct ligation. They were classified into three groups according to the treatment: (1) SHAM group (2) I-Group: Sanfenon BG3^™ :Taiyokagaku, Co. Ltd, Mie, JAPAN (50mg/kg/day) was oraly administed. (3) NI-Group: no treatment. They were put to beneficial death in the 17th postoperative day. Evaluated parameters were as following: measurement of serum AST, ALT , Activator Protein-1 m-RNA (AP-1 m-RNA) in hepatic tissues, grade of immunohistochemical staining with 8-oxo-2' deoxyguanosine (8-OHdG), 4-Hydroxynonenal (4-HNE), Transforming Growthfactor -β1 (TGF-β1), and α-smooth muscle actin (α-SMA).
Result: Serum AST, ALT, AP-1 m-RNA in the I-Group were significantly lower than those in the NI-Group. Grade of Azan,α-SMA,TGF-β1,4-HNE, and 8-OHdG staining in the I-Group significantly decreased, comparing to the NI-Group.
Conclusion: Green tea catechin might be suppress the hepatic fibrosis by controlling oxidization stress and a transcription factor.

View full abstract

[in Japanese]

View full abstract

[in Japanese]

View full abstract