Purpose: In multidisciplinary therapy for pediatric cancer, accurate pathological diagnosis is essential, and the most suitably designed chemotherapy regimen must be initiated as soon as possible after biopsy. We retrospectively evaluated our methods for tumor biopsy.
Methods: We reviewed the clinical records of 61 patients of 4.9 ± 5.0 years old (mean ± SD) with the following malignant tumors: Neuroblastoma (n = 25), malignant lymphoma (n = 12), nephroblastoma (n = 5), rhabdomyosarcoma (n = 5), hepatoblastoma (n = 1), and others (n = 13).
Results: The mean operative time was 124 ± 41 min. Blood loss was 36 ± 50 g; tumors were approached by laparotomy in 42, thoracotomy in 2, subcutaneous lymphnode biopsy in 11, and other procedures in 6 patients. Specimens were obtained from the main tumors in 52, and from metastatic lesions in 9 patients. We did not observed surgical complications in any patient, and pathological diagnosis of the biopsy specimen coincided well with that of the resected tumor. The mean time period between the tumor biopsy and the commencement of chemotherapy was 5.6 ± 4.4 days.
Conclusions: We obtained adequate specimens with our biopsy technique, and the respective specimens provided accurate pathological diagnoses. Because the respective specimens from the metastatic lesions also facilitated pathological diagnoses, it suggests that biopsy specimens from metastatic lesions could be useful in certain fragile patients.
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