薬剤学
Online ISSN : 2188-3149
Print ISSN : 0372-7629
ISSN-L : 0372-7629
74 巻 , 2 号
選択された号の論文の18件中1~18を表示しています
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  • Mizuho Osawa, Kenjirou Higashi, Jun Yamashita, Kunikazu Moribe, Keiji ...
    2014 年 74 巻 2 号 p. 160-169
    発行日: 2014年
    公開日: 2014/04/16
    ジャーナル フリー
    The purpose of this study is to evaluate the applicability of solid dispersions prepared with hydroxypropyl cellulose (HPC). Solid dispersions were prepared with sulindac, a poorly water-soluble drug, and HPC of three different molecular weights using a hot melt extrusion method. Physicochemical properties of the solid dispersions were characterized by powder X-ray diffraction (PXRD), differential scanning calorimetry (DSC), and solubility studies. Permeability of sulindac was evaluated using the Caco-2 cell monolayer model. The results obtained by PXRD, DSC, and solubility studies showed that sulindac in the extrudate of sulindac/HPC (20/80 w/w) was completely amorphized and demonstrated better solubility than the drug alone. Permeability of sulindac across Caco-2 cell monolayers remarkably increased when the drug was solid-dispersed with the lowest molecular weight form of HPC (HPC-SSL). It has been concluded that HPC-SSL can be the most effective excipient in order to improve solubility and membrane permeability.
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