薬剤学
Online ISSN : 2188-3149
Print ISSN : 0372-7629
ISSN-L : 0372-7629
81 巻, 4 号
選択された号の論文の16件中1~16を表示しています
巻頭言
学会賞等受賞者紹介
夢対談
偉人伝
リレーフォーラム
R&D
研究室紹介
若手研究者紹介
イントロダクション
コロキウム
レポート
ノート
  • 川上 裕士, 徳村 忠一
    2021 年 81 巻 4 号 p. 311-318
    発行日: 2021年
    公開日: 2021/10/01
    ジャーナル フリー

    Summary: The aim of the present study was to establish a method for preparing an oral liquid dosage form of sildenafil (SIL) citrate from Revatio® 20 mg tablets (R-tab) that may be administered to patients in neonatal intensive care units (NICU). Croscarmellose sodium (CCS) in R-tab adsorbs SIL in aqueous solution by Langmuir-type adsorption, and the maximum adsorbed amount of the drug per unit weight of CCS and its constant were 1.45 mmol/g and 0.787 L/mmol, respectively. The adsorption of SIL by CCS was inhibited by the addition of sodium chloride and citric acid at concentrations of 0.05% or higher. A suspension with 0.5 mg/mL of SIL was prepared from R-tab, and sodium chloride and citric acid were added to the suspension at concentrations of 0.05 and 0.9%, respectively. Decreases were observed in drug concentrations in the supernatants of suspensions prepared from R-tab with or without sodium chloride. The reason for these reductions was an increase in pH due to the dissolution of calcium monohydrogen phosphate anhydrous. A SIL oral liquid dosage form for use in NICU was prepared from R-tab by the addition of citric acid to prevent adsorption and maintain pH.

 
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