There are few epidemiological studies of multiple amputations in Japan. In this study, we conducted a survey using a database operated by the National Rehabilitation Center for Persons with Disabilities to clarify the epidemiological characteristics of multiple amputees. As a result of analyzing 140 multilimb amputees who were subject to prosthetic limbs made at our center during the 41 years from 1979-2019, bilateral upper limb amputation was mainly male amputation due to industrial accidents, bilateral lower limb amputation was mainly caused by traffic accidents, diabetes and angiogenic diseases, and the proportion of women was higher than that of unilateral upper and lower limb amputation and triple limb amputation, and all cases of unilateral upper and lower limb amputation and triple amputation were traumatic injuries mainly in traffic accidents, and no characteristics were found in gender. Quadruple amputation was mainly caused by diseases such as purpura fulminans, and the proportion of women was the largest compared to other amputation sites, and the average age was higher. Over time, the number of quadruple amputees has increased, the number of amputees has aged, and the number of amputees due to disease has tended to increase.
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