The efiects of 50% Nitrous oxide and 50% Oxygen premixed gas were examined clinically, hematologically and blood-chemically in dogs of experimental group (I) premedicated iv. with Atropine salfate and the group (II) premedicated iv. together with Atropine salfate and Combelen. Other animal species were premedicated with Atropine salfate.
From the result of the inhalation of Anesoxyn-50, it was not useful for the anesthesia in all examined animals. But it was effective for hypnosis in dogs, and also in cats and cynomologus monkeys the hypnosis was produced at first 5 to 15 mintes during the inhalation. In mice and small birds, it was no effective for hypnosis.
Hematocrit decreased significantly at 20 minutes during the inhalation in group I as compared with that observed before inhalation.
Heart rate decreased significantly at 20 minutes during the inhalation in group II.
PO₂ increased significantly in two groups and as weell PaO₂ increased particularly. Furthermore, PaCO₂ increased significantly at 50 minutes during the inhalation in group II.
Although blood glucose increased only by the stimulation of setting gas mask with the animals, it rised moreover at 20 minutes during the inhalation in group II.
Toxic important factors were not observed clinically from this study.

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Dogs were administrated thiopental sodium to perform sedation and then were maintained anesthesia with ether gas. The stimulative effects of thiopental sodium and ether gas on the cardiofunction were inhibited or antagonized by premedication of chlorpromazine. This is the anesthetization to utilize the addition and the potentiation effects because sedatic, inductic and anesthetic drugs were administered by time difference. This method is excellent because it can obtain the effective narcosis with a smaller quantity of drugs.
Thiopental sodium has the action of the respiratory-circulatory inhibition which is characteristic side-effect of barbiturates. However, when thiopental sodium is administered controling the medication dose and is administrated speedy for the intention of only inducing but anesthetizing, the defects of this drug were lessened cleary and the effects of the respiratory stimulation of ether gas were doubled.
Before-mentioned, inhalation anesthetization never meet the danger of respiratory acidosis from hyperinhalation of ether gas (ITOH, 1970) . And this general anesthesia has no sideeffedts such as halothan's respiratory-circulatory inhibition or liver disturbance, therefore we believe this technique to contribute on the field of veterinary clinic.
The supply of ether gas was performed on 30 dogs immediately after the induction was practiced by this technique. PTG and ventilation volume were measured and recorded, and also the alteration of ether gas concentration from inspiration to exdiration wes examined with arterial and venous blood and urine.
From before-mentioned experimental results :
1) The intravenous injection narcosic such as pentobarbital sodium must not be understood as simple changes of administration methods or the anesthetic drugs. The anesthesia ought to perform in three steps, namely premedication, induction and maintenance.
2) These three step anesthetization are ;
a) Chlorpromazine 2 mg/kg im. (Premedication)
b) Thiopental sodium 8.3 mg/kg iv. 1/3 of usual. (Induction)
c) The inhalation 10—15% ether gas when necessary. (Maintenance) This anesthesia method is excellent in comparison with the injectional anesthesia and conventional ether gas inhalation, because it brings a greater effect with a little dose and yet is much more stable.

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[in Japanese]

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