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Volume 33 (2013)
- Issue 131 Pages 6-
- Issue 130 Pages 1-
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Volume 33, Issue 131
Displaying 1-6 of 6 articles from this issue
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Reviews
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Tsutomu TAJIKAWA, Masako NAKATA-KOYANAGI2013 Volume 33 Issue 131 Pages 6
Published: 2013
Released on J-STAGE: October 01, 2014
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Masahiro NISHIDA, Ryo KOSAKA, Osamu MARUYAMA, Takashi YAMANE2013 Volume 33 Issue 131 Pages 7-12
Published: 2013
Released on J-STAGE: October 01, 2014
JOURNAL FREE ACCESS
Supplementary materialIn the blood pump development, such as artificial heart or extracorporeal circulation pump, the most important property is the hemocompatibility to prevent thrombus formation that can be investigated from the fluid mechanical point of view. The mechanism of the thrombus formation is that the blood coagulation factor is activated by high shear or foreign body reaction and that it proceeds to cause thrombus formation in low shear and stagnant region. Therefore, the risk of the thrombus formation in the artificial heart and the extracorporeal circulation pump can be predicted by the quantitative evaluation of the flow stagnation inside the pumps with the fluid mechanical methodology such as quantitative flow visualization and the computational fluid dynamic analysis. In this manuscript, the role of the flow visualization in the development of artificial heart and extracorporeal circulation pump with focusing the risk of thrombus formation.View full abstractDownload PDF (399K) -
Akio FUNAKUBO, Norihiko HATA, Ichiro TAGA, Yasuhiro FUKUI2013 Volume 33 Issue 131 Pages 13-18
Published: 2013
Released on J-STAGE: October 01, 2014
JOURNAL FREE ACCESS
Supplementary materialIn this study, we constructed an automatic optimization system applying the multi-objective genetic algorithm(MOGA)and developed an artificial lung possessing high gas exchange performance based upon fluid dynamics. The system consists of a three dimensional CAD system, computational fluid dynamic software and the optimization tool. We set the objectives to minimize the priming volume, to minimize the volume of the low flow region and to minimize standard deviation of the flow rate in the fiber bundle. The optimum designs were manufactured using a rapid prototyping system and were examined by evaluating gas exchange performance in in-vitro experiments. At the results, oxygen transfer rate increased by average of 18%, also, carbon dioxide transfer rate increased by an average of 40.5% when compared with the original design. The results suggest that the system was not only effective for reducing time, cost and labor of developing artificial organs but was also useful as a design and developing support system.View full abstractDownload PDF (373K) -
Kiyotaka IWASAKI, Mitsuo UMEZU2013 Volume 33 Issue 131 Pages 19-24
Published: 2013
Released on J-STAGE: October 01, 2014
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- Development of Painless Needle Imitating Mosquito -Seiji AOYAGI2013 Volume 33 Issue 131 Pages 25-28
Published: 2013
Released on J-STAGE: October 01, 2014
JOURNAL FREE ACCESS
Supplementary materialPaying attention to mosquito proboscis as an ideal model of painless needle, a mosquito penetrating motion was observed in detail using a system comprising high-speed camera system and magnification lens with long working distance. The following facts were proven, i) the mosquito proboscis is composed of plural needles, two of which, i.e., maxillae, have jagged protrusions along its tip area, ii) the central labrum, which plays an important role of sucking blood, and the side two maxillae, are advanced alternatively with certain time phase to each other, the vibration of which is at several Hz, while the total three needles are gradually forward. Imitating precisely the shape and the size of these three needles, microneedles were fabricated using micromachining technique. The puncture forces of three needles against an artificial polymer skin were measured, proving that the cooperative alternative motion is much effective for reducing the necessary force for penetrating the skin, compared to the non-cooperative motion.View full abstractDownload PDF (489K) -
―Applications of origami folding techniques for medical devices and regenerative medicine―Kaori KURIBAYASHI-SHIGETOMI2013 Volume 33 Issue 131 Pages 29-34
Published: 2013
Released on J-STAGE: October 01, 2014
JOURNAL FREE ACCESS
Supplementary materialOrigami folding technique has been widely used in various fields including space structures and medical fields. Recently, it is known as “Origami Engineering”. In this paper, I will introduce the application of origami engineering in medical fields, particularly for medical devices and regeneration medicine. Using the origami folding technique, a new type of a stent graft has been developed. Unlike the conventional stent grafts which consist of a wire mesh and a covering membrane, the proposed stent graft can be made from a single folded sheet of material. Also, three-dimensional (3D) cell-laden microstructures has been produced using origami folding technique and the cell traction force (CTF). Three-dimensional (3D) cell culture is widely employed for fundamental research in cell biology, drug discovery, tissue engineering, and regenerative medicine.View full abstractDownload PDF (687K)
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