We report 2 cases of lymph node infarction.
Case 1: A 71-year-old female with generalized lymphadenopathy was admitted. The biopsied lymph node showed lymph node infarction. She was diagnosed with malignant lymphoma with CD20 (+) by immunohistochemical studies. On the 11
th hospital day, severe anemia with mild elevated indirect bilirubin appeared. A diagnosis of cold agglutinin disease was made. On the 15
th hospital day, CHOP therapy was given and, after 5 days, Rituximab therapy was started. After the treatment with 8 cycles of R-CHOP therapy, she maintained complete remission (CR).
Case 2: An 81-year-old female was admitted because of anorexia, lt-pleural effusion, and lymph node swelling in the rt-supraclavicular area. She had acute myelogenous leukemia but achieved CR by chemotherapy. Leukemic infiltration to the pleural effusion and tuberculous pleurisy were ruled out by pleural effusion cytology. More than half of the biopsied lymph node demonstrated infarction.
A diagnosis of myeloid sarcoma was made by immunohistochemical studies. After 3 cycles of chemotherapy, the lymph node swelling disappeared. Four bone marrow aspirations revealed CR in the course of the disease.
However, she died from severe anorexia.
We should consider malignant lymphoma when a biopsied lymph node shows infarction, and immunohistochemical studies are essential.
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