Rupture of atherosclerotic plaque causes serious results. Since heterogeneity of the mechanical properties causes stress concentration which results in material failure, a local plaque volume was compared with local strain in circumferential direction. Rabbit thoracic aortas with atherosclerosis were excised and four needles were stuck into them at equal intervals on their circumference. From the movement of the needles during pressurization of the specimen, local circumferential lengths were calculated. Local circumferential strains were calculated by referring to the circumferential lengths at the stress-free state. Pressure strain elastic modulus
Ep, stiffness parameter
β, and incremental elastic modulus
Einc were calculated. Total thickness
Ttotal, plaque thickness
Tplaque, medial wall thickness
Twall, and area fraction of plaque
Aplaque were also measured in histological sections.
Einc and
β obtained in the present study were comparable to those of the previous studies. Local strain at 80 mmHg
ε80 correlated significantly with
Twall (
r = 0.37,
p< 0.05) and
Ttotal (
r = 0.36,
p< 0.05) while
ε80 had insignificant correlation with
Tplaque and
Aplaque. These results indicate that atherosclerotic plaque has insignificant effects to their mechanical properties, and
Twall becomes more uniform at physiological state than at the stress-free state.
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