Major Histocompatibility Complex
Online ISSN : 2187-4239
Print ISSN : 2186-9995
ISSN-L : 2186-9995
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Volume 21, Issue 2
Displaying 1-5 of 5 articles from this issue
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The 2014 Workshop Textbook for Certified HLA Technologists
  • Applications of HLA gene polymorphisms
    Katsushi Tokunaga
    2014 Volume 21 Issue 2 Pages 87-95
    Published: 2014
    Released on J-STAGE: August 11, 2014
    DOIhttps://doi.org/10.12667/mhc.21.87
    JOURNAL FREE ACCESS
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    Human MHC (major histocompatibility complex) or HLA genes exhibit the highest degrees of polymorphisms. These polymorphisms play important roles not only in transplantation and transfusion but also in various other fields including human evolution, paternity test, personal identification, disease susceptibility, and drug hypersensitivity. Our experiences in the studies on the origin and formation of East Asian populations, susceptibility and resistance genes to narcolepsy, hepatitis B virus-related diseases, and Stevens-Johnson syndrome are described.
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  • Trends of HLA allele typing and antibody testing in 16th IHWS and 39th ASHI
    Hiroto Kojima
    2014 Volume 21 Issue 2 Pages 97-104
    Published: 2014
    Released on J-STAGE: August 11, 2014
    DOIhttps://doi.org/10.12667/mhc.21.97
    JOURNAL FREE ACCESS
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    The results of HLA allele typing and antibody testing are important especially in case of organ and hematopoietic cell transplantation. Therefore, the subjects about methodology and accuracy of result are sometimes focused on at conference. In fact, there were many subjects about HLA testing at 16th IHWS (16th International histocompatibility Workshop) and 39th ASHI (39th American Society for Histocompatibility and Immunogenetics Conference). In the view of HLA allele typing, NGS (Next Generation Sequencing) was capturing the spotlight as new technology. And in the field of HLA antibody testing, the standardization of protocol in a technique, the epitope and complement fixing HLA antibody in an analysis were the major subjects. In this short review, I summarize the detail contents at 16th IHWS and 39th ASHI in HLA testing that is a little bit different from direction of Japan.
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  • Renal transplantation and the role of histocompatibility testing in it
    Kenji Yuzawa
    2014 Volume 21 Issue 2 Pages 105-118
    Published: 2014
    Released on J-STAGE: August 11, 2014
    DOIhttps://doi.org/10.12667/mhc.21.105
    JOURNAL FREE ACCESS
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    The graft survival after renal transplantation has been improved especially after the development of new immunosuppressive drugs. Before that, in the better matching of HLA we selected the donor, the better survival of the graft we could get after renal transplantation. Now, many people think the role of histocompatibility matching became less important. But it’s not true. In cadaveric donor renal transplantation, no mismatch of the HLA leads excellent survival of the graft. Before and after organ transplantation, using high sensitive anti-HLA antibody testing developed recently, we can predict and prevent the antibody mediated rejections. To understand the importance of histocompatibility testing in organ transplantation, the present status of renal transplantation is reported. Moreover, the problems of the histocompatibility testing in present organ transplantation and the outlook of histocompatibility testing for the future are described.
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Review
  • Diversity of Bovine MHC Class II DQA1 Gene
    Shin-nosuke Takeshima, Yoko Aida
    2014 Volume 21 Issue 2 Pages 119-129
    Published: 2014
    Released on J-STAGE: August 11, 2014
    DOIhttps://doi.org/10.12667/mhc.21.119
    JOURNAL FREE ACCESS
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    The cattle MHC class II region is divided into two subregions, named class IIb and class IIa. Class IIb contains non classical class II genes, and class IIa region contains classical class II genes. Previously, the BoLA-DRB3 had been mainly analyzed for class IIa polymorphism, but recently we developed PCR-SBT method for high-resolution genotyping of the BoLA-DQA1 gene, which enable to analyze class IIa haplotype including the BoLA-DQ loci. In this review, we focused on the BoLA-DQA1 polymorphism among various cattle breeds and the association between DQA gene and disease susceptibility.
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