Oral Medicine & Pathology
Online ISSN : 1882-1537
Print ISSN : 1342-0984
ISSN-L : 1342-0984
13 巻, 3 号
選択された号の論文の6件中1~6を表示しています
Review
  • Hitoshi Nagatsuka, Katase Naoki, Han Phuu Pwint, Hidetsugu Tsujigiwa, ...
    原稿種別: Review
    2009 年 13 巻 3 号 p. 81-89
    発行日: 2009年
    公開日: 2009/06/24
    ジャーナル フリー
    Heparan sulphate proteoglycans (HSPGs) constitute a group of ubiquitous macromolecules of cell surface and extracellular matrices (ECM). HS chains of HSPGs can bind numerous molecules including growth factors, cytokines and chemokines. Thus the degradation of HS chains by endoglycosidases will affect profoundly cell function. Heparanase is a mammalian endo-β-glucuronidase enzyme capable of selectively degrading HS chains. Aside from the enzymatic functions, heparanase is preferentially expressed by human tumors, and its over-expression in tumor cells provides invasive phenotype. We previously reported that heparanase expression and the HS-bound molecules are important for odontogenesis and development of odontogenic tumors. It can be concluded that the growth and progression of benign and malignant odontogenic tumors are related to the deranged immunoexpression and localization of HS and heparanase molecules and that heparanase may be responsible for growth and progression of odontogenic tumors by modulating the availability and function of HS binding growth factors.
Original
  • Hideto Tajima
    原稿種別: Original
    2009 年 13 巻 3 号 p. 91-98
    発行日: 2009年
    公開日: 2009/06/24
    ジャーナル フリー
    Epulis osteoplastica shows pathological ossification, but details of the mechanism involved are still unclear. In the present study we carried out histopathological and immunohistochemical analyses to clarify the potential for ossification in epulis osteoplastica (n = 8), in comparison with epulis fibrosa, using several markers. Epulis osteoplastica showed particulate, massive, trabecular and osteoid ossification surrounded by proliferating fibroblasts and fibrous tissues under the mucosal squamous epithelium. Epulis fibrosa showed proliferation of fibroblasts and collagen fibers without ossification. Although positive immunoreactivity for bone morphogenetic proteins 2, 4 and 6, osteocalcin, osteopontin, and ostenectin was observed in the fibroblasts of epulis osteoplastica, the cell positivity rates were much higher in epulis osteoplastica than in epulis fibrosa, suggesting that these substances were associated with pathological ossification in epulis osteoplastica. Furthermore, the findings indicated that the fibroblasts in epulis osteoplastica might have a higher ability to produce bone matrix production than those in epulis fibrosa.
  • Kazuo Komiyama, Tadashi Tsuruta, Shotaro Mukae, Yusuke Amano, Yasuhiro ...
    原稿種別: Original
    2009 年 13 巻 3 号 p. 99-104
    発行日: 2009年
    公開日: 2009/06/24
    ジャーナル フリー
    Type V secretory phospholipase A2 (sPLA2-V) has been implicated in several pathophysiological events including inflammation, eicosanoid production, and antibacterial defense. However, its expression has been recognized in only a few organs such as the heart and lung. This study is the first to demonstrate preferential expression of sPLA2-V in human salivary glands by immunohistochemistry and in situ hybridization. In normal tissues, sPLA2-V was expressed in a constitutive manner in serous cells and scarcely in duct epithelia, but not in mucous cells. In contrast in sialoadenitis, sPLA2-V expression was up-regulated in duct epithelia and some mucous cells, while the tumor cells of pleomorphic adenoma strongly expressed the enzyme. We concluded that sPLA2-V in salivary glands may play a role for saliva secretions and anti-bacterial defense, in as well as assist in the progression of sialoadenitis and salivary gland tumor formation through prostaglandin production.
Case Report
  • Kamal Al-Eryani, Faleh A. Sawair, Satoshi Maruyama, Masahide Watanabe, ...
    原稿種別: Case Report
    2009 年 13 巻 3 号 p. 105-110
    発行日: 2009年
    公開日: 2009/06/24
    ジャーナル フリー
    Nerve sheath myxoma is a rare benign tumor of nerve sheath origin that typically presents as a small solitary skin nodule and rarely affects the oral cavity. A case of nerve sheath myxoma of the tongue in a 51-year-old male is reported. The patient had a painless submucosal nodule in the lateral margin of the tongue for several months. The tumor was surgically removed under local anesthesia. Histopathologically, the removed tumor consisted of several loosely textured myxofibrous nodules in which spindle- or stellate-shaped cells with eosinophilic cytoplasm and hyperchromatic nuclei were scattered. Immunohistochemically, the myxoid stroma was strongly positive for perlecan, a basement membrane type heparan sulfate proteoglycan, and the tumor cells were individually circumscribed by type IV collagen-positive fibers. In addition, the tumor cells were strongly positive for vimentin, S-100 protein, neuronspecific enolase, and cathepsin D. However, they were not positive for epithelial membrane antigen, neurofilament protein, CD34, CD10, calponin, actin, or any subtypes of keratin. A review of the literature revealed that 11 cases of oral nerve sheath myxoma had been documented. The mean age of the patients was 29 years old, and there was no predilection between males and females. They arose most frequently in the tongue.
  • Megumi Yokoyama, Hiroyuki Okada, Miyuki Morikawa, Hirotsugu Yamamoto
    原稿種別: Case Report
    2009 年 13 巻 3 号 p. 111-114
    発行日: 2009年
    公開日: 2009/06/24
    ジャーナル フリー
    Glandular odontogenic cyst (GOC) is a relatively rare jaw cyst. We report a case of GOC arising in the retromolar region, and associated with an impacted third molar of the mandible in a 37-year-old man. The surgical specimen was investigated histopathologically and immunohistochemically. Immunohistochemically, cytokeratin 19 was positive in the whole layer of the cystic lining as well as in the duct-like parts. The lining epithelia showed labeling indices of 7.2 for PCNA, 3.2 for topoisomerase IIα, and 11.6 for Ki-67, respectively. These results indicated odontogenic and rather proliferative nature of GOC.
  • Dilrukshi Nupehewa, Primali Rukmal Jayasooriya, Manjula Attygalla, Wan ...
    原稿種別: Case Report
    2009 年 13 巻 3 号 p. 115-117
    発行日: 2009年
    公開日: 2009/06/24
    ジャーナル フリー
    Oral squamous cell carcinomas (OSCC) and Warthin tumors are relatively common lesions that are encountered in patients who present with head and neck tumors. However, synchronous occurrence of these two tumors is a rare phenomenon. This report describes a 61-year-old patient with a squamous cell carcinoma of the right side of his buccal mucosa, who received extensive surgery including bilateral neck dissection. Histopathological examination of the neck dissection, however, revealed a Warthin tumor of the right parotid gland. It is important to be aware of such a presentation of Warthin tumor to avoid overtreatment for OSCC.
feedback
Top