Autoregulators, which in common have a butyrolactone skeleton, are widely distributed among Streptomyces. Biosynthetic pathway of one of these autoregulators, virginiae butanolide A, was proposed on the basis of isotope labeled precursors incorporation experiments. The identification of the receptor protein for butyrolactone autoregulators in Streptomyces virginiae and its purification, characterization and cloning are also reviewed.
A dynemicin producer, strain M956-1 was placed in the genus Micromonospora. The strain was distinguished from the hitherto described species on the basis of the quantitative analysis of menaquinones and fatty acids, the cell wall-diamino acid composition and the physiological characteristics. Accordingly the name, Micromonospora chersina sp. nov. is proposed for this strain; the type strain is strain M956-1 (=ATCC 53710).