Toyama Medical Journal
Online ISSN : 2758-819X
Print ISSN : 1883-2067
Volume 18, Issue 1
Displaying 1-9 of 9 articles from this issue
FINAL LECTURE
INAUGURAL LECTURE
ORIGINAL ARTICLE
REVIEW
REVIEW
  • Masahiko KANAMORI
    2008Volume 18Issue 1 Pages 34-38
    Published: 2008
    Released on J-STAGE: July 20, 2023
    JOURNAL FREE ACCESS
     Little information is available on the molecular mechanisms underlying oncogenesis of dedifferentiated chondrosarcoma. To obtain an overview of the genomic imbalances characterizing this tumor, we analyzed by karyotypes and comparative genomic hybridization (CGH) and reviewed the previous literatures. Cytogenetically, multiple complex abnormalities were observed in each case, but dedifferentiated chondrosarcoma has not shared common abnormal changes in karyotypes. The chondroid portion and anaplastic portion showed similar karyotype suggesting monoclonal origin, not collision tumor. The conspicuous CGH results suggested that chromosome 9 was most critical region in dedifferentiated chondrosarcoma. It may therefore supply a possible data of oncogenic mechanism of this tumor.
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