YAKUGAKU ZASSHI
The Pharmaceutical Society of Japan, established in 1880, is one of Japan’s oldest and most distinguished academic societies. The Society currently has around 15,000 members. It publishes three monthly scientific journals. Chemical and Pharmaceutical Bulletin (Chem. Pharm. Bull.) began publication in 1953 as Pharmaceutical Bulletin. It covers chemistry fields in the pharmaceutical and health sciences. Biological and Pharmaceutical Bulletin (Biol. Pharm. Bull.) began publication in 1978 as the Journal of Pharmacobio-Dynamics, which then merged the Journal of Health Science, another former Society’s journal, in 2012. It covers various biological topics in the pharmaceutical and health sciences. Yakugaku Zasshi (Japanese for “Pharmaceutical Science Journal”) has the longest history, with publication beginning in 1881. Yakugaku Zasshi is published mostly in Japanese, except for some articles related to clinical pharmacy and pharmaceutical education, which are published in English. The main aim of the Society’s journals is to advance the pharmaceutical sciences with research reports, scientific communication, and high-quality discussion. The average review time for articles submitted to the journals is around one month for first decision. The complete texts of all of the Society’s journals can be freely accessed through J-STAGE. The Society’s editorial committee hopes that the content of its journals will be useful to your research, and also invites you to submit your own work to the journals.

Chairman of Committee
Hidehiko Nakagawa
Graduate School of Pharmaceutical Sciences, Nagoya City University
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Published by The Pharmaceutical Society of Japan  
18,287 registered articles
(updated on August 15, 2026)
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
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2025 Journal Impact Factor (JIF)
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Featured article
Volume 146 (2026) Issue 8 Pages 723-731
Fragment Molecular Orbital Calculation Analysis of Influenza Neuraminidase and Inhibitor Interactions
Mizuka Onishi, Tomoka Taguchi, Ayaka Masuda, Kaori Fukuzawa

The interactions between 4 compounds used as influenza neuraminidase inhibitors—oseltamivir, zanamivir, laninamivir, and peramivir— and influenza virus neuraminidase were analyzed using pair interaction energy decomposition analysis based on fragment molecular orbital (FMO) method, quantitatively elucidating binding characteristics of each inhibitor. Our calculations revealed that structures with common functional groups showed similar binding characteristics, whereas structures with functional groups differing in hydrophilicity/hydrophobicity showed different types of intermolecular interactions for the same amino acid residues. Such analysis is expected to be effective for precise molecular design in structure-based drug design.
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Editor's pick

The interactions between 4 compounds used as antiviral drugs —oseltamivir, zanamivir, laninamivir, and peramivir— and influenza virus neuraminidase were analyzed using the fragment molecular orbital method, quantitatively elucidating binding characteristics of each inhibitor. While the common functional groups showed similar binding characteristics, different functional groups in hydrophilicity/hydrophobicity showed different types of intermolecular interactions for the same amino acid residues. Such analysis is expected to be effective for precise molecular design in structure-based drug design.

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