Riluzole is a drug used to manage amyotrophic lateral sclerosis (ALS). Previous reports indicate a high incidence of liver injury in patients taking riluzole. Therefore, this study aimed to determine the risk factors for liver injury among patients who were prescribed riluzole from 1999 to 2015. As a result, concurrent use of CYP1A2 inhibitors, and history of smoking are independent risk factors associated with the development of liver injury in ALS patients who are prescribed riluzole.
What Is Qualitative Research?
Released: June 01, 2017 | Volume 137 Issue 6 Pages 653-658
Mechanism of Cell Proliferation—Cell Cycle, Oncogenes, and Senescence
Released: November 01, 2006 | Volume 126 Issue 11 Pages 1087-1115
Elucidation of a New Mechanism of Onset of Insulin Resistance: Effects of Statins and Tumor Necrosis Factor-α on Insulin Signal Transduction
Released: November 01, 2018 | Volume 138 Issue 11 Pages 1329-1334
Research Misconduct in Japan and How It Is Covered by the Media
Released: April 01, 2018 | Volume 138 Issue 4 Pages 459-464
Optimization of Immunosuppression and the Prevention of Fungal Infection in Autoimmune Diseases
Released: October 01, 2015 | Volume 135 Issue 10 Pages 1123-1127