Intrinsic 5-HT synthesized within the mammary epithelium has an important physiological role in milk volume homeostasis. When the mammary gland becomes filled with milk, 5-HT provides a negative feedback signal that suppresses further milk synthesis in the mammary epithelium. Our research, using MCF-12A cells, shows that the expression of b-casein, a differentiation marker, is suppressed via 5-HT-mediated inhibition of STAT5. Additionally, our results show that reduced b-casein expression in the cells is associated with 5-HT7 receptor and PTP1B activation.
What Is Qualitative Research?
Released: June 01, 2017 | Volume 137 Issue 6 Pages 653-658
Examination of Factors Affecting Adverse Reactions and Dosage Reduction in UGT1A1 Genotyped Patients: A Retrospective Survey of Irinotecan
Released: February 01, 2012 | Volume 132 Issue 2 Pages 231-236
Keinosuke Okazaki, Toru Watanabe, Isao Saito, Jun-Ichiro Murayama
Furanocoumarins Contents and Cytochrome P450 3A (CYP3A) Inhibitory Activities of Various Processed Fruit Peel Products: Outflow of 6′,7′-Dihydroxybergamottin during Processing Treatment of Peel
Released: May 01, 2011 | Volume 131 Issue 5 Pages 679-684
Masaru ISHIHARA, Hikaru TODA, Nobuyoshi SUNAGANE, Takafumi OHTA
Collaborative Approach to Heart Failure Care
Released: August 01, 2016 | Volume 136 Issue 8 Pages 1115-1116
Hiroyuki Takano, Yukihito Sato
Mechanism of Cell Proliferation—Cell Cycle, Oncogenes, and Senescence
Released: November 01, 2006 | Volume 126 Issue 11 Pages 1087-1115