After injected once bovine's serum antigen toward the normal rabbit, and the rabbit with impediments in the reticulo-endothelial function due to ink injection and splenorectomy, I have pro kg 5γ of Platonin in two groups injections three times every other day and the same amount once a day for the whole week continuously (7 times), and then have taken observations on such matters as Congo-red index, serum protein density especially γ-Globulin, precipitin value, and quantitative changes, and obtained the results as follows'.
1) In case of normal rabbit, the injections three times every other day has shown remarkable effect than that of once a day for the whole week continuously; in case of rabbit with impediments in the reticulo-endothelial function due to splenorect my and ink injection, the latter has indicated more remarkable results than the former.
2) Among every groups, antibody production has proved at its maximum in 14 days after antigen injection, but has gradually showed decrease. When the antibody production has proved at its maximum as quickened by injection of Platonin, it could be seen that the decline in precipitin value and quantitative changes has proved as slowly especially in former compared with others, and antibody in serum has kept for a long time.
3) In this chapter, the precipitin value and quantity has proved at its maximum as quickened in every groups compared with the case of no administration of Platonin as reported at Chapter One, and injection of Platonin has proved to quicken upon the antibody production.
4) Serum protein esp. γ-Globulin showed almost a parallel relation with antibody, while no definite changes could be seen. When the function of reticulo-endothelial system has proved as quickened by administration of Platonin, the quickened state of antibody production has kept for a long time and at a high level. Further, decline of the reticulo-endothelial function due to splenorectomy has equally showed decrease of γ-Globulin. Therefore, it may be roughly conduluded that a close correlation exists among the reticulo endothelial function, serum protein and γ-Globulin.

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After having once injected cow's serum antigen toward both a normal rabbit, as well as a rabbit with impediments in the reticuloendotherial function due to ink injection, I examined and have taken observations on such matters as Congored Index, total serum protein density, precipitin value, as well as quantitative changes that happened; which, offered results as follows:
1. In case of a normal one, the total protein density of antiserum, along with γ-Globulin quantity, almost showed a parallel relation with the precipitin changes. In those viccisitudes that have occurred in α- and β-Globulin as well as Congored Index, no definite tendency could be detected.
2. In case of a splenorectomized rabbit, there occurred an increase in Congored Index, accompanied with a decrease in the total serum protein density, albumin, as well as γ-Globulin, on the day that followed the operation. Moreover, an increase has taken place in β-Globulin.
3. In an ink-filled rabbit, there could be seen, within a day of injection, certain increase in the Congored Index, along with a decrease in total serum protein density, albumin or γ-Globulin.
4. In those rabbits who underwent splenorectomy and ink-injection, no serum protein acting parallel with the precipitin changes, as seen in a normal one, could be observed.
5. The precipitin production has proved at its maximum in a normal rabbit, in 20 days after antigen injection; while, in 20-30 days in case of an operated one; and 14 days in the injected rabbit, among these three groups, the injected rabbit showed maximum; next, normal one, and lastly, rabbit who suffered the operation.
6. At 85th days after the injection, of antigen, a decline in precipitin has proved marked in all the three groups, esp., very eloquent in an operated rabbit.
7. From the above results, it may roughly be concluded that a close correlation exists between γ-Globulin and antibody; further, the role of reticuloendotherial system as mother ground for antibody production may be considered with some significance.

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運動の外在・内在フィードバックモデルを言語運動に適用し, 言語課題で熟知度の低いことばの朗読はDAF効果を受けやすく, 練習や語の有意味性によって熟知度が高くなるほど, フィードバックが内在化してDAF効果が小さいであろうと予想して, 実験的検証を試みた.小学6年生の男女60名を均質な3群に分け, W群は単語, NS群は無意味綴り, NSP群は練習した無意味綴りの刺激語を朗読させた.流暢さの指標として1秒当たりの正しいモーラ数〈CMR〉をとり, DAF効果を〈1-DAFのCMR/NAFのCMR〉と定義した.
被験者全体では熟知度の高い単語はDAF効果は小さく, 熟知度の低い無意味綴りはDAF効果は大であった.無意味綴りの練習群と非練習群とのDAF効果には, 被験者全体としては有意差がなかったが, 男女間では男子は練習群が非練習群よりDAF効果が有意に大きく, その逆に女子では練習群が非練習群よりDAF効果が小さくなる傾向がみられた.DAF効果には性差があり, 無意味綴り練習群と単語群に有意に認められた.

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This experiment was an extension of the one previously reported. From the viewpoint of the external and internal feedback models for speech control, the following hypotheses were studied.
1) The DAF index of familiar words was less than that of nonsense syllables.
2) The DAF index of repeated practice groups was less than mthat of single practice groups.
3) The DAF index of girls was less than that of boys.
The DAF index was used to indicate DAF effects, which was defined by the following formulla: 1- (CMR under DAF/CMR under NAF) . CMR was the correct morae rate of reading per second.
The subjects read 6 familiar words and 6 unfamiliar nonsense syllables. 45 boys of the 5th grade with normal speech habit were divided equally into three groups, who practiced 1, 10 and 30 times before the DAF test. 45 girls were similarly chosen and divided.
The 2nd and 3rd hypothesis were supported but the 1st was not. Although it was not significant, the DAF index of the familiar words was less than that of nonsense syllables in the 1 and 30 practice groups, but in the 10 practice groups, the result was reversed. Measuring reading difficulties under the DAF, it was also proved that the DAF index represented validity and generality as an index of the DAF effect.

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The purpose of this study was to examine the existence of the cognitive system which exclude irrelevant feature (i, e. relative size and color) as a criteria for recognition of membership of a specific category effectively in interpreting the meaning of “dog” and “animal”. The subjects were children aged five to six years. In Experiment 1, when the experimenter gave a novel label to two target dogs which were different in size and color, subjects interpreted the label as referring to dogs which were different in size or color from the target dogs. In Experiment 2, when the experimenter gave a novel label to target a dog and a cat which were different in size and color from each other, subjects interpreted the label as referring to dogs and cats which were different in size and color from the target dog and cat. The findings suggested that subjects excluded the relative size and color as a criteria of recognition of membership of a category in interpreting “dog” and “animal”, and the above mentioned cognitive system does exist.

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The present experiment was designed to examine the eftects of the numbers of letter and word upon CNV components, by using a modified Sternberg's paradigm. The results indicated that CNV amplitude decreased and CNV rising time increased as a function of the numbers of letter and word. CNV resolution time increased with the number of word, while no increase in resolution time was observed with the number of letter. These findings were discussed in relation to recent information processing models.

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Effects of bromelain on absorption, distribution and excretion of josamycin were investigated in the normal and experimentally infectious rat.
When given orally, josamycin was slowly absorbed from upper part of small intestine. Its marked. affinity of tissue was observed, and it was slowly excreted in the urine. When combined with bromelain, peaks of its plasma and organ concentrations were observed earlier than the control and it was excreted more rapidly. Affinity of kidney and spleen for josamycin was slightly greater than that of liver in view of biological activity, while affinity of liver was greater when isotopically measured. Bromelain accelerated the permeability of intestine to josamycin, and increased its passage into external fluid from intestine at alkaline pH.
It is concluded therefore that bromelain accelerates absorption of josamycin and elevates early blood. and organ levels.

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During the Korean War (1950-53), Misao Onda (1916-96) implemented the pedagogical method of “Seikatsu-Tsuzurikata” (life writing) at a Kawashimo secondary school in Iwakuni city, Yamaguchi Prefecture. Through an analysis of Onda’s practices, this paper examines the range of the “SeikatsuTsuzurikata” movement in the early 1950’s in relation to U.S. military base problems.

First, this paper considers Onda’s compilation process of a collection of school essays, “Delta” No. 3. It originated from his investigation of essays that reflected children’s responses to Iwakuni U.S. military base problems within “Seikatsu-Tsuzurikata” assignments. He invariably used children’s diverse insights and thoughts as a starting point for his practices. This provided an opportunity for him to relativize Cold War thought. Second, this paper analyses the nature of the content of “Delta” No. 3. Its structure has two functions. The first is to coordinate the scope of the children’s perceptions and the depth of their thoughts, the second to promote their collaboration in engaging in life in a “military base town.”

Onda’s practice is closely related to the build up of the Cold War in East Asia. However, Onda’s practices show the realistic potential of “Seikatsu-Tsuzurikata” that takes up the trends of education influenced by political background of the Cold War.

Finally, this paper investigates the relationship between the nationwide response to “Delta” No. 3 with the planned publication of Ikutaro Shimizu, et al, The Child of the Military Base (1953). “Delta” No. 3 attracted attention nationwide as a pioneering example of “Seikatsu-Tsuzurikata” that took up military base problems. However, as interest in the subject grew, it was subjected to repeated editing and redirection. As a result, its original two functions and the opportunity of relativizing Cold War thought was eliminated.

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近年, 溶血連鎖球菌の培養液から抽出したStreptokinaseおよびStreptodornaseが, 壊死組織融解剤としての効果がみとめられて以来, Trypsin, Pepsin, Ficin, Bromelain等の蛋白分解酵素も潰瘍性病変に対して, その壊死組織の除去を目的として皮膚科領域で使用されている。さらに平山1, 2)は, 酵素剤を炎症局所に投与したぱあい, 抗生物質の病巣内への滲透性を高めることによつて, 膿汁中の抗生物質濃度を著るしく高め得ることを述べ, さらにまた, 病巣内に局所的に注入した抗生物質は, より高濃度に末梢血中に移行することを証明し, 酵素剤との併用効果があることを報告している。これらはいずれも, 酵素剤を局所的に応用したものであるが, 最近柴田ら3)は, 蛋白分解酵素を筋注, 静注または口腔内投与しても, 筋肉内に注射されたペニシリンの膿中または血中への移行を著るしく促進することをみとめており, Bromelain4)やVaridase (StreptokinaseおよびStreptodornase) 5)を抗生物質と同時に経口投与し, 臨床的に好成績をおさめた例も報告されている。しかし, 蛋白分解酵素を経口的に投与したばあいの抗生物質の各組織への移行量に対する影響を比較検討した報告は少なく, わずかに徳田ら6, 7)がBromelain, Proctase (Protease), Lysozymeを用いて, また石井ら8), PECILEら9)がα-Chymotrypsinを用いて血中および皮下組織中の抗生物質濃度に対する影響を比較検討しているにすぎない。
そこでわれわれは, 酸性Protease製剤“コロナーゼS”(以下, CNと略) を用いて, これとクロルテトラサイクリン (以下, CTCと略) とを同時に鶏またはラッテに経口投与したばあいの心, 肝, 腎, 肺, 脾, 膵, 睾丸, 脳などの各種臓器ならびに血液, 胆汁, 筋肉へのCTC移行量をCTC単独投与のぱあいと比較検討した結果, CNがCTC吸収を促進する成績を得たので, 報告する。

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