「デンマークと日本の人間教育」と題する本論文も今回で6回目となった。 第1回から一貫して取り上げてきたのは，池田とヘニングセンによる対談集「明日をつくる“教育の聖業”」（以後，「対談集」と略記）についてであった。 第5回目では，池田を人生の師匠と仰ぎ，ヘニングセンを学問の恩師と慕う神尾のデンマークでの青年時代を，彼の自叙伝を元に綴ってみた。 本稿でも，その続編を書く予定であったが，自叙伝という性格から論文には馴染まないところもあるため，続きは彼の回顧録集に譲ることにした。 したがって，本稿ではデンマークSGIとアスコー校を舞台として，神尾が繰り広げてきた知られざる「教育と平和の友好交流」の経過について，書き遺しておくことにする。 　「人間教育はカリキュラムでするものではなく教育者の人格でするもの」とのヘニングセンの言葉が思い起こされる。1） 神尾の行動を振り返ってみると，緻密な計画性は薄いが，思い込んだら即実行に移す行動力に優れた人物であると筆者は見ている。つまり，神尾にとっての人間教育の行動は，用意されたカリキュラムに則ったものではなく，コルがそうであったように，民衆の幸福を第一に考える師匠，池田やグルントヴィの教えに忠実な彼の純粋な性格から生まれたものと考えられる。 その彼に思想上の大きな影響を与えた人物が池田であり，ヘニングセンであったと言えよう。 本稿は，それらの具体的行動の足跡と今後の発展性について考えようとするものである。

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経食道心エコー法で描出された胸部大動脈Mモードエコー図からstiffness parameter βを計測することにより, 動脈硬化症の診断における有用性について大動脈脈波速度との比較を通し検討した. βと脈波速度の間には相関係数が0.539と正の相関がみられ, ともに加齢に伴い増加する傾向が認められた. 動脈硬化症の危険因子である高血圧症もしくは高脂血症を有する群ではβ, 脈波速度ともに有意に高い結果を示した. また, 胸部大動脈に粥状硬化や石灰化の認められた症例ではβは有意に高い結果を示したが, 脈波速度は粥状硬化では有意差を認めるものの, 石灰化では高い傾向を示すにとどまった. さらに, 冠動脈や脳動脈に硬化性疾患を有する症例でもβ, 脈波速度ともに有意な高値を示したが, より細小血管である網膜動脈硬化症ではβは有意な高値を示すものの脈波速度では有意差は認められなかった. 以上より, 胸部大動脈stiffness parameter βの測定は動脈硬化症の診断に有用であり, 画像とともに病変の広がりや質的類推においても有用であると考えられた.

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We assessed atherosclerotic lesions (AL) of the thoracic aorta and its stiffness in 17 patients with familial hypercholesterolemia (FH; 51±9 ys) and 21 normal subjects according to age by conducting biplane two-dimensional transesophageal echocardiography (TEE: 5MHz). The descending aorta was divided into 4 portions with equal lengths and the degree of AL was classified into 4 categories by TEE depending on the severity of AL: Score-1=intimal thickening, 2=atheromatous plaque, 3=calcified plaque associated with acoustic shadowing behind the lesion. The AL in the descending aorta (DAo) was scored. In all patients with FH, AL with a score higher than 1 was frequently observed in the aortic arch and the DAo; however, none of control subjects had AL with a higher score than 1. In 6 of all FH patients (35%), AL with a higher score than 3 was found in the aortic arch and the DAo rather than in the ascending aorta. The total atherosclerotic score (TAS: sum of scores obtained from each portion) was significantly higher in the FH (3.8±1.5) than in the control subjects. We also measured instantaneous dimensional (D) changes of the DAo in a cardiac cycle by conducting a TEE M-mode echography while monitoring the 2-D view. The stiffness parameter (β=ln (Ps/Pd)/(D_max-D₀)/D₀, where Ps: systolic blood pressure, Pd: diastolic blood pressure, D_max: maximum aortic dimension during the ejection period, D₀: minimum aortic dimension during the pre-ejection period) in the FH (subjects (10.2±4.3) was significantly greater than in the control subjects (5.1±1.2, p<0.001) although there were no significant differences in the D₀ of the control subjects, indicating increased aortic stiffness in the FH subjects. In both control and FH subjects, β was correlated with age (r=0.61, p<0.01, r=0.65, p<0.01, respectively). In the FH subjects, β or TAS was correlated well with the total cholesterol level (r=0.63, p<0.05, r=0.65, p<0.01, respectively). Thus, TEE with a biplane probe proved to be a reliable method to evaluate the well property of the thoracic aorta. Even in the relatively younger population of the FH, group, the incidence of AL in the thoracic aorta was significantly higher than in the control subjects. Moreover, this higher incidence of AL was accompanied by increased aortic stiffness.

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Daunorubicin, 1 mg/kg by rapid intravenous infusion daily for 7 consecutive days, was given 7 cases with previously untreated acute promyelocytic leukemia. In order to prevent the possible exacerbation of disseminated intravascular coagulation due to a sudden release of procoagulant from abnormal promyelocytes damaged by the potent antileukemic drug, heparin was administered intravenously at daily doses of 150 mg concurrently with chemotherapy.
Complete remission occurred in 4 cases. Maintenance therapy consisting of 6 to 9 intravenous injections of daunorubicin at 7-day intervals followed by oral 6-mercapto purine at daily doses of 100 mg was given to these patients. Remissions lasted 27, 30, 68 and 128 weeks. There has been no sign of relapse in the latter two cases. up to the time of this report. The most serious side effects of treatment were severe neutropenia and thrombocytopenia lasting for 2 to 3 weeks after initiation of the therapy, necessitating an intensive antibiotic therapy and platelet transfusion. Fibrinogen level rose after instituting administration of heparin in 2 of the 4 patients treated successfully, while it temporarily decreased in the remaining 2 cases and started to increase first when the mass of abnormal promyelocytes diminished. In none of the cases the bleeding tendency was intensified during heparin administration.
Three patients died of intracranial hemorrhage after treatment for 1,4 and 5 days, respectively. The possibility that heparin gave rise to the fatal hemorrhage in these patients cannot entirely be excluded. It is noteworthy, however, that remission was not produced in any of 11 cases treated at our clinic with various antileukemic agents other than daunorubicin before the introduction of the present protocol, and that 6 of 7 patients in this group without combined use of heparin died also of intracranial hemorrhage with a median survival of 8 days after the establishment of diagnosis.

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