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  • 牧野 荘平
    アレルギー
    2005年 54 巻 5 号 487-488
    発行日: 2005/05/30
    公開日: 2017/02/10
    ジャーナル フリー
  • 石崎 達
    日本内科学会雑誌
    1969年 58 巻 12 号 1287-1292
    発行日: 1969/12/10
    公開日: 2008/06/12
    ジャーナル フリー
  • 小舘 昭示
    やどりが
    2013年 2013 巻 235 号 29-33
    発行日: 2013/01/10
    公開日: 2017/08/19
    ジャーナル フリー
  • 石崎 達
    耳鼻咽喉科展望
    1969年 12 巻 4 号 233-239,226
    発行日: 1969/08/15
    公開日: 2011/08/10
    ジャーナル フリー
    The characteristic features of allergic diseases in common are discussed.
    Allergic disorders exhibit considerable hereditary influence but our knowledge of the inherited allergic constitution is yet incomplete. It is assumed than (1) sensitized antibodies are easily produced, (2) there is hypersensitivity to chemical mediators and (3) the ability to inhibit the action of chemical inhibitors is absent, and these peculiarities probably result in the recurring manifestations of allergic symptoms. The processes by which the allergic symptoms are produced are discussed in relation to the above-mentioned peculiarities as well as to infection. Lastly, various problems concerning therapeutic measures are discussed.
  • 岩本 東子, 真崎 博昭, 渡辺 震, 津田 一行, 山村 好弘
    医療
    1978年 32 巻 1 号 114-116
    発行日: 1978/01/20
    公開日: 2011/10/19
    ジャーナル フリー
    我々は, 第1報において, 当院における外来および入院患者について, 患者血清中のIgE値を測定し, 特に臨床的に興味ある症例として, 肺結核症患者で薬物アレルギー併発の患者に対して, 抗結核剤IHMSとEBによる減感作療法を2年間にわたり行い, 臨床症状, 臨床検査値共に非常によい成績を得たので, 第2報として報告する.
  • 石崎 達, 可部 順三郎, 都丸 正明, 中川 圭一郎
    大気汚染研究
    1972年 7 巻 1 号 7-12
    発行日: 1972/08/30
    公開日: 2011/08/11
    ジャーナル フリー
    Fifteen asthmatic patients of atopic type at the Tokyo Kyosai Hospital were followed up their symptoms through the asthma-patient-diary prepared by the present authors during the period from Nov. 18, 1969 to Feb. 6, 1970, and the hourly changes of air pollutants (SO2 and suspended particles) were measured and recorded automatically by an air pollution recorder settled in this hospital.
    The day of ingravescent of symptoms especially with asthmatic attacks was checked for each patient during the observation period, and the patient-number of ingravescent in each day was recorded and analysed for the health effect of air pollution. The asthmatic patients showed a tendency to develop critical symptoms on the day when severe air pollution as SO2 over 0.2 ppm in maximum took place (among the day) and also when suspended particles were over 50% by the measurement of transparency decrease of filter paper. The influence of severe air pollution upon asthmatic attack seemed to continue to the subsequent day.
    Although the lung function tests using a Benedict Roth respirometer as well as Body pletysmograph were investigated upon over 6 patients, no significant correlation was recognized between the data of the tests and the air pollution factors.
  • 石崎 達, 牧野 荘平, 池森 亨介, 福田 健, 生井 聖一郎, 山本 久, 古内 一郎, 河島 文幸, 石崎 百合子
    産業医学
    1979年 21 巻 2 号 153-163
    発行日: 1979/03/20
    公開日: 2008/04/14
    ジャーナル フリー
    Clinical mass surveys were carried out on the residents to whom questionnaires on symptoms with reference to strawberry culture in the vinyl-house had been delivered. Two hundred and eleven persons attended at the first survey in September, 1976 (off the season of strawberry culture) and the 58 attended at the second survey in March, 1977 (within the season). The participants of the first survey consisted of three groups, i.e. farmers with and without strawberry culture and people without farming. The participants of the second survey consisted only of farmers with strawberry culture. Results are summarized as follows. 1) There were no difference of incidence of various clinical findings detected by an ophthalmologist and otolaryngologists among the three groups. 2) There were also no difference of incidence of abnormal findings in urine tests, liver functions, respiratory test, blood examinations and blood pressure test among the three groups. However, the comparison of persons in charge of strawberry culture and attended at both of the first and the second surveys, such changes were detected as increases in the value of GOT (within normal limits), of stab neutrophiles, lymphocytes and of monocytes within the season of strawberry culture. 3) Increases of positive rates in skintest by extracts of house dust and Candida sp. were observed in the farmers with and without strawberry culture. Positive rates of skintest by strawberry pollen and honey bee extracts among the farmers with strawberry culture were markedly higher than the allergic patients in Dokkyo Hospital having no relation to this culture. This positive rate was markedly elevated among the persons who complained the symptom of rhinorrea within the season. 4) In conclusion, there was no serious health effect by strawberry culture upon the farmers as far as routine clinical examinations show, except overwork, symptoms from unusual stance during the work in the house. However, it is clear that persons with allergic constitution shall be sensitized by strawberry pollen and honey bee extracts which develop nasal symptoms due to antigen-antibody reaction.
  • 石崎 達也
    トライボロジスト
    2021年 66 巻 12 号 880
    発行日: 2021/12/15
    公開日: 2021/12/15
    ジャーナル 認証あり
  • 石崎 達也
    トライボロジスト
    2020年 65 巻 12 号 716
    発行日: 2020/12/15
    公開日: 2020/12/15
    ジャーナル 認証あり
  • 石崎 達, 村中 正治, 大塚 正己, 宮本 昭正
    アレルギー
    1963年 12 巻 3-4 号 131-133,136
    発行日: 1963/03/30
    公開日: 2017/02/10
    ジャーナル フリー
    Resulted from cutaneous injection made trially with the diagnosis solution of Paspat (1/l00 solution) in the healthy person group (202 persons), bronchial asthmatic group (35 persons), and antiallergic disorder group (13 persons), the positive rate of the healthy group was quite low (wheal l% and erythemata 2%), but that of the asthmatic group showed 11% on wheal and 29% on erythemata, that is, Paspat indicated to have a tendency to be easily causable to the positivity in the asthmatic, who had a strong infectious factor. Consequently, in case the positivity of Paspat diagnosis solution has a concern with Paspat treatment, it is surmised as effectiveness in the asthmatic, who gets stronger the infectious factor than the inhalation factor. In conclusion, the author expresses our gratitude to Prof. Yoshio Oshima for his kind guidance and revise.
  • 小児喘息との関連に於ける考察
    林 鷹治, 中本 明良, 海田 智行, 小野 菊男
    耳鼻咽喉科臨床
    1967年 60 巻 12 号 1087-1100
    発行日: 1967/12/01
    公開日: 2011/10/14
    ジャーナル フリー
  • 大島 秀彦, 今井 正之, 川岸 富希子, 伴野 楠郎
    大気汚染研究
    1973年 8 巻 2 号 126-133
    発行日: 1973/06/30
    公開日: 2011/08/11
    ジャーナル フリー
    We investigated the incidnce of dieseases in Yokkaichi area through the records of National Health Insurance System from April 1961 to March 1970. There was remarkable difference between polluted and non-polluted districts in the incidences of upper respiratory diseases, common cold and bronchitis, bronchial asthma and asthmatic bronchitis, and a group of diseases in the front parts of eye. The incidence of bronchial asthma had significant correlation to sulphur dioxide level in the districts in 1964, but it had no significant correlation in 1970. The incidences of chronic bronchitis and emphysema were significantly correlated with the concentration of sulphur dioxide in the districts in 1970.
  • 3 皮内反応閾値, 臨床的分析および臨床諸検査
    加茂 悦爾, 藥袋 勝, 石崎 達
    Japanese Journal of Tropical Medicine and Hygiene
    1978年 6 巻 1 号 27-42
    発行日: 1978/06/15
    公開日: 2011/05/20
    ジャーナル フリー
    The threshold dilution of positive skin test was analysed on the 217 subjected patients and followed up for several years. Clinical features and laboratory tests were statistically analysed on two skin-test positive groups, Group I (egg+ by rectal biopsy), II (egg-) and Group C (Control). Group III (skin test -, egg-) was not reasonable as the control, because many of them were treated for schistosomiasis previously. Therefore, the control was selected from the healthy persons in the non-endemic area by the physical and laboratory examination. Group IV (skin test-, egg+ ) was excluded from the analysis because of the small number.
    I. The threshold value of positive skin test
    1) It was markedly higher in the younger generation than in the older; it was higher generally in men than in women.
    2) It decreased sharply in the Niridazole-treated group, while it was changeless or slowly decreased in the non-treated group during several years.
    II. Clinical features
    Analyses on the frequency of the patients in the endemic area, of the threshold dilution titer, the COP positivity and the stool examination supported that the intensity of the schistosomal infection decreased in such order as I>II>III.
    1) The frequency of complications with the disease ranged as I>II>III in decreasing order.
    2) The incidence of hypertension was in such order as I > II > C, and abnormalities on the chest film as I≅II>C.
    3) The incidence of the prolonged QT and other abnormalities in ECG decreased in order as I>II>C.
    4) The higher incidence of hepatomegaly was recognized in I than in II, whereas no such a case in C.
    III. Laboratory tests
    1) The incidence of abnormal liver function decreased in such order as I>II>C in each parameter.
    2) The incidence of anemia and leucopenia decreased in order as I or II>C, and a hemopoietic dysfunction due to the disease was suspected.
    3) The incidence of abnormality in serum K, Na and total cholesterol level ranged as I or II>C. The incidence of proteinuria was also in order as I or II>C.
    Thus, it was clarified that clinical and metabolic disorders were significantly brought about due to schistosomiasis japonica.
  • 後藤 敬子
    北関東医学
    1958年 8 巻 6 号 549-555
    発行日: 1958/11/25
    公開日: 2009/10/15
    ジャーナル フリー
    1) Hookworm eggs in 3 g of normal feces showed nearly random distribution. But after a definite amount of feces solution was repeatedly obtianed by The Stoll's method, the number of the eggs in it came to show nearly Poisson distribution. 2) It is consequently possible to estimate the number of eggs per gram (E. P. G.) by counting the number of the eggs contained in any definite amount of feces solution obtained by the Stoll's method.
  • 寺西 秀豊, 加須屋 実, 青島 恵子, 加藤 輝隆, 五十嵐 隆夫
    産業医学
    1982年 24 巻 5 号 465-470
    発行日: 1982/09/20
    公開日: 2008/04/14
    ジャーナル フリー
    An epidemiological survey of pollenosis was carried out on 96 farmers engaged in a pear orchard in Toyama prefecture. All subjects were asked about the complaint of clinical manifestations from pollens and examined by the intradermal skin test with pollen extracts. Airborne pollens were collected in the pear orchard using a gravity sampler. The results are as follows. 1. Many pollen grains of annual bluegrass (Poa annua L.) and other grasses were observed in the atmosphere of the pear orchard throughout the late April to May. Almost all pollen grains of Japanese pear (Pyrus pyrifolia Nakai) were found in the late April, although a few of them were detected during May. 2. The prevalence rate of nasal symptoms and ocular symptom of the farmers was about 20%. The peak of incidence of nasal symptoms and ocular symptom was observed in April to June. During these months, artificial pollinations of Japanese pears are carried out and the annual bluegrass pollens were wafting in the air. 3. Positive skin reactions to Japanese pear pollens were observed in 5.4% of the farmers and positive skin reactions to annual bluegrass pollens in 31.5% of them. All the positive skin reactors to Japanese pear pollens also showed the positive skin reaction to annual bluegrass pollens. The positive reaction to annual bluegrass pollens was more common among the farmers who worked more than 11 years than those worked less than 10 years. 4. Nasal symptoms such as sneeze were more common among the positive skin reactors to annual bluegrass pollens compared with the negative skin reactors. The seasonal peak of nasal and ocular symptoms was observed only among the positive skin reactors. These results suggest that the pear farmers were exposed to the pollen grains of Japanese pear and annual bluegrass, and the pollen allergens sensitized them inducing nasal and/or ocular symptoms.
  • 2 直腸生検の価値
    加茂 悦爾, 薬袋 勝, 石崎 達
    Japanese Journal of Tropical Medicine and Hygiene
    1977年 5 巻 2 号 141-154
    発行日: 1977/09/15
    公開日: 2011/05/20
    ジャーナル フリー
    For the clinical evaluation of rectal biopsy, 217 patients with a variety of complaints, who were treated in the Koma-Kyoritsu Hospital during 1967 to 1973, were tested by rectal biopsy, the threshold value of skin test, the COP test and feces examination under the suspicion of chronic schistosomiasis japonica.
    1) The detection rate of fresh eggs by rectal biopsy was markedly higher in the younger age-group below 30 years. This rate became also significantly higher in parallel with the increase of egg-number in the rectal specimen.
    2) The incidence of hemorrhoids was significantly higher in the group with old eggs only than that containing fresh eggs.
    3) After the treatment with Niridazole, the eggs detected by rectal biopsy decreased in number and they were degenerated or destroyed as compared with the pretreatment status.
    4) Histological examination of the stained specimen obtained by rectal biopsy showed such reaction as eosinophilia of slight degree or edema around the fresh eggs, suggesting an antigenicity of the fresh eggs. However, it was of less importance from the diagnostic point of view, comparing with the press examination of the raw material, because of difficulty to discover the egg and to observe it au naturel.
    5) In accordance with the increase of the threshold diluting grade of positive skin test, the number of the egg became larger, moreover, the incidence of fresh eggs became higher by rectal biopsy, that is, the number and quality of the egg had a correlation with the threshold value of skin test.
    6) Even in the egg-negative cases in feces, the possibility of finding the egg was 56% by rectal biopsy. The incidence of the case containing fresh eggs in the biopsy was significantly higher in the egg-positive cases than the egg-negative ones in feces.
    7) The incidence of relatively fresh eggs in rectal biopsy was significantly higher in the COP-positive group in comparison with the COP-negative group.
    8) Though the technic was rather difficult, more eggs were found statistically in the posterior wall of the rectum than in the anterior. However, even though in small number, the probability of finding the egg was larger from the anterior wall than the posterior in woman.
    Thus, rectal biopsy was of great value in the diagnosis and treatment of the disease in Japan.
  • 皮膚
    1985年 27 巻 3 号 646
    発行日: 1985年
    公開日: 2010/06/04
    ジャーナル フリー
  • 石崎 達郎, 甲斐 一郎
    日本老年医学会雑誌
    2000年 37 巻 6 号 472-478
    発行日: 2000/06/25
    公開日: 2009/11/24
    ジャーナル フリー
    埼玉県内の某病院において, 1989年5月から1993年4月までの4年間に訪問医療 (訪問診療, 訪問看護) の対象となった患者 (59名) について, 訪問医療開始後1年間における急性期治療を目的とした入院 (以下, 急性期入院と略す) の有無を調べた. そして, この急性期入院発生の有無が患者の身体状況や訪問看護・訪問診療の内容等とどの様な関連があるか検討した. 主な調査項目は, 年齢, 性別, 疾患名, 日常生活動作 (以下, ADLと略す) の状況, 痴呆の有無, 訪問開始時における血清アルブミン値, 訪問開始日, 訪問医療の回数 (訪問看護, 訪問診療), 訪問時に実施した各種医療処置の有無等で, 情報収集には各患者の診療録を用いた.
    対象者は, 女性が63%, 平均年齢は77.4 (±9.7) 歳, 主な疾患は, 脳血管疾患が53%, 悪性腫瘍14%, 神経系疾患10%であった. 調査対象者に対する訪問医療の提供頻度は, 中央値10.7日 (レンジ: 2.0~21.1日) に一回の頻度であった. そして, 訪問医療開始後1年以内に急性期入院となった患者は全体の59% (35名) にのぼった.
    Cox 比例ハザードモデルを用いて, 訪問医療開始後1年間における急性期入院発生に関連する要因を検討した結果, 平均訪問頻度の影響を調整してもADLレベル (ランクC) (ハザード比 (HR)=3.13, 95%信頼区間 (CI)=1.34~7.35), 血清アルブミン値3.5g/dl未満 (HR=3.05, 95%CI=1.37~6.77) が急性期入院の発生と有意に関連していた. このようなリスクを有する者に対しては, 急性期治療を目的とした入院のタイミングを逃さないように, 全身状態の変化に充分注意する必要があろう.
  • 石崎 達郎, 甲斐 一郎, 平山 登志夫
    日本老年医学会雑誌
    1995年 32 巻 2 号 105-110
    発行日: 1995/02/25
    公開日: 2009/11/24
    ジャーナル フリー
    老人保健施設 (以下, 老健施設と略す) は, 病院に入院している要介護老人の家庭復帰を促すために開設された. ところが, 実際の退所先には家庭の他に, 病院, 特別養護老人ホーム (以下, 特養と略す), 他の老健施設等があり, 家庭復帰した利用者は全体の半数に留まっているといわれている. 老健施設利用者の家庭復帰にはどのような要因が関与しているか明らかにするために, 一老健施設利用者の属性や利用状況を退所先別に比較, 検討した (比較I:「退所先家庭群」対「退所先病院群」, 比較II:「退所先家庭群」対「退所先特養・他の老健施設群」). ショートステイを除く4年間の全入所者389名 (平均年齢81.1±6.0歳, 女性67.1%) を対象に, 入所記録から利用者の年齢, 性別, 入所前の生活場所, 入所期間, 退所先, 日常生活動作能力 (以下, ADLと略す), 知力障害の有無を調べた.
    多重ロジスティック回帰の結果, 比較Iでは性別は男性, 入所期間が長い者, 家庭からの入所者, ADLレベルの高い者で家庭に戻った者が多かった. 一方, 比較IIでは, 家庭からの入所者, 入所期間が短期, ADLレベルの高い者で家庭に戻った者が多かった.
    今回の調査対象施設では, 医療機関から老健施設に入所した者は再入院しやすく, 老健施設の当初の目的であった「病院から家庭への通過施設」として運営されることは困難であることが示唆された. 利用状況だけでみる限りでは老健施設は専ら「要介護老人の在宅ケア支援施設」として利用されていると考えられる. 入所の早い段階で利用者の退所先に影響を及ぼす要因を評価して家庭復帰の可能性を検討すれば, 入所者の退所先を予測するうえで有用となろう.
  • 中村 晋
    医療
    1966年 20 巻 12 号 1241-1248
    発行日: 1966/12/20
    公開日: 2011/10/19
    ジャーナル フリー
    Seventy six cases of urticaria had been treated in our Allergy Centre during the period from July 15, 1954 to July 14, 1965. The results of clinical studies especially of the intracutaneous test are as follows;
    1) As to the sexual distinction, on the whole, the number of the male was almost the same as that of the female (1: 1.05), but in the youth-prime generation the female was predominant in number, and the third decade was most frequent then the twenty decade.
    2) Observing on the type of urticaria, 52.6% of the total cases belonged to the chronic type, and 25.0% were the acute.
    3) 68.4 % of the 76 cases had the hereditary factor.
    4) 63.2 % of the patients with acute type of urticaria and 32.5 % of those with chronic type of urticaria had food allergy, most frequently caused by fish (as mackerel, tunny, bonito and horse-mackerel) and smell-fish, and frequently by egg, cereal or vegetable, meat and milk.
    5) The intracutaneous test by food allergen extracts was applied on each subject.
    The frequency order of positive reaction was as follows: firstly as to fish and shell-fish group, lobster (23 %, the highest of all), tunny, bonito, crab, salmon, sardine, cuttlefish, and so on; secondly as to egg, meat and milk group, processed food (such as sausage or ham) and so on; and lastly as to cereal or vegetable group, positive reaction was caused
    by cortinellus shiitake, bamboo-shoot, egg-plant, tomato, spinach, taro, coltsfoot and peanut. But the positive reaction to intracutaneous test of these substances, especially in chronic urticaria, was generally less notable than in bronchial asthma, and either false positive or false negative reaction was often seen.
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