The local irritation effect of T-1220 was investigated as compared with that of ABPC or CBPC. The results obtained are as follows.
1) 25 and 50% solution of T-1220 and 50% solutions of ABPC or CBPC were dropped in the lower eyelid of rabbits. Appreciable inflammation of the cornea and conjunctiva was not caused by the solutions.
2) 25, 35 and 50% solutions of T-1220, ABPC or CBPC were administered intracutaneously to the abdominal skin of rats, and thereafter Evans blue was injected intravenously to the same rats. In the region administered with test sample, the area of dye spot and the amount of Evans blue were measured, and the results indicated that the local irritation effect of T-1220 was almost equal to that of ABPC or CBPC.
3) 25 and 35% solutions of T-1220 or CBPC were administered intramusculary to adult and juvenile rabbits. Judging from the examinations, muscle weight, gross local reaction and the histological observation, the local irritation of T-1220 was a little milder than that of CBPC. The inflammatory reactions on the drugs were almost similar in adult and juvenile.
4) In the ear of rabbits, 20% solutions of T-1220, ABPC and CBPC were allowed to remain in the sealed section of the vein. The frequency of thrombogenesis, length of thrombus, area of inflaming region and histological observation were examined. The results showed that local irritation effect of T-1220 was a little milder or equal to that of ABPC or CBPC.
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