廃棄物処理・リサイクル関連施設において事故が頻発している。処理の高度化や新しい技術の適用が進む中で、設計メーカ等には安全かつ安定して運転が可能な施設設計が求められている。そこで、有識者の技術を定量的に整理するとともに、過去に発生した事故やトラブル事例を有効に活用することで、安全かつ経済的な設計の評価を可能とする安全設計評価手法(Safety design analysis with database)を開発・改良している。本稿ではの高度化を図るとともに、普及を目指し開発したソフトウェアについて示す。アプリケーションは事故・トラブル・ヒヤリハット事例データベースおよび別途構築している安全向上策データベースを参照して、安全性評価対象の技術の評価から安全向上策の検討までを自動的に行うことができるものである。

抄録全体を表示

廃棄物処理・リサイクル関連施設において事故が頻発している。投入されてくる廃棄物の性状の変化及びリサイクルの要請が増す中で、設計メーカ等には安全かつ安定して運転が可能な施設設計が求められている。そこで、有識者の技術を定量的に整理するとともに、過去に発生した事故やトラブル事例を有効に活用することで、安全かつ経済的な設計の評価を可能とする安全設計解析手法(Safety design analysis with database)を開発している。本稿ではの高度化を図るとともに、普及を目指し開発したソフトウェアについて示す。アプリケーションは事故・トラブル・ヒヤリハット事例データベースおよび別途構築している安全向上策データベースを参照して、安全性評価対象の技術の評価から安全向上策の検討までを自動的に行うことができるものである。

抄録全体を表示

Formula for electric resistivity ρ, derived in the first part of this work has developed to the case when the coupling of carriers to the rest part of many particle system, can be described by a local pseudopotential, like to the case of liquid metals and alloys. Resistivity of liquid alkali metals has been calculated, and specific lines of numerical calculations by the new formula have been analysed and comments given. According to our results, the scattering of carriers accompanied by the wave vector transfer in amount of q, is of essential importance, not only for q<2k_f, but also for q above of double Fermi radius k_f, q>2k_f, in opposite to the Ziman’s formula, which takes into consideration and accounts only the region q<2k_f.

抄録全体を表示

By two partial integrations in succession, Kubo’s formula for electric conductivity σ(ω), has been reduced to an expression giving σ(ω) by a force-force time correlation functions, which in the limit ω→0 behaves like an indeterminate ratio (0/0). This ratio has been resolved by the use of L’Hospital rule, and has given an expression for DC conductivity, which is suitable for practical calculation, more than original Kubo’s formula.

抄録全体を表示

Increased short-term blood pressure variability is known to be associated with hypertensive target organ damage. Sinoaortic denervation (

SAD

) induces a marked increase in blood pressure lability without affecting the average blood pressure level. The aim of this study was to investigate the effects of blood pressure lability on endothelial vasomotor function and neointimal formation after balloon injury in

SAD

rats. Direct long-term measurement of mean arterial pressure showed no significant difference in the average of mean arterial pressure between the

SAD

group and sham-operated control group. In contrast, the standard deviation of mean arterial pressure, as an index of blood pressure lability, was 3-fold greater in

SAD

rats. To study endothelial function, isometric tension of aortic rings was measured 4 weeks after

SAD

or sham operation. Endothelium-dependent vasorelaxation induced by acetylcholine was significantly reduced in the

SAD

group (20% reduction at maximum relaxation). Endothelium-independent vasorelaxation induced by sodium nitroprusside was similar in each group. Acetylcholine-induced NO release from aortic rings was significantly reduced in the

SAD

group. Next, we examined neointimal formation in carotid arteries in

SAD

and sham-operated rats at 2 weeks after balloon injury. The neointimal-to-medial area ratio in the

SAD

group was 50% higher than that in the sham-operated group. The percentage of proliferating cell nuclear antigen-positive cells in the intima was significantly higher in the

SAD

group. These findings suggest that increased blood pressure lability, independently of average blood pressure level, impairs endothelial function by inhibiting NO production, enhances neointimal formation after balloon injury, and may thereby contribute to atherogenesis. (Hypertens Res 2003; 26: 991-998)

抄録全体を表示

Background: Patients with social anxiety disorder (

) have heightened self-reflection. In the self-focused cognition, they ruminate negative self-image or evaluation both by themselves and others. It leads to self-conscious emotions, such as embarrassment. Previous functional magnetic resonance imaging (fMRI) studies with healthy subjects revealed that anterior rostral medial prefrontal cortex (arMPFC) plays a key role in self-reflection. However, neural basis of self-reflection in patients with has not been studied in detail. This study aimed to investigate the neural basis of self-reflection in patients with using self-face images. We hypothesized that patients with would show excessive embarrassment and it would cause aberrant neural hyperactivity in arMPFC as compared to controls (CTL).

Methods: Thirteen outpatients with

and 17 CTLs enrolled in this study. fMRI was acquired while participants reported the degree of their embarrassment by the visually presented their self-face image and images of others' with and without an observer.

Results: The

group reported significantly greater embarrassment for self-face images than the CTL regardless of observation. The group showed enhanced self-related activation in the left arMPFC as compared with the CTL. Furthermore, positive correlation between the self-related activity and Liebowitz Social Anxiety Scale was observed only in the arMPFC.

Conclusion: We suggest that the arMPFC takes charge of their elevated-level of self-reflection in patients with

, and the level of the neural activity was correlated to the severity of the symptom.

抄録全体を表示

It is known that Social Anxiety Disorder () has high prevalence among Anxiety Disorders. In previous studies, it was suggested the attentional control, anxiety sensitivity, and depression symptoms were considered to be a maintaining and aggravating factors of anxiety disorders, including . In present study, we investigated the effects of each factor on symptoms. Multi regression analysis by stepwise method showed that these factors have significant effects on symptoms (attention control; β = .24, p < .01; depression symptoms; β = .22, p < .01; anxiety sensitivity; β = .20, p < .01, respectively). Present results indicated that attentional control, anxiety sensitivity, and depression symptoms may have the influence of the reinforcement of symptoms. Future studies, it was required to examine the difference between and other anxiety disorders. Finally, the future direction of the cognitive behavior therapy on attentional control, anxiety sensitivity, and depression symptoms in treatment was discussed.

抄録全体を表示

Differential thermal analysis experiments are carried out on two reentrant liquid crystals, CBOBP and OBBC, whose phase sequences are Crystal–S_A1–RN––N–I and Crystal–RN––N–I, respectively. The reentrant phase transition (RN/) is accompanied by a significantly smaller thermal anomaly than the ordinary ones (S_A1/RN and /N). S_A1/RN had a larger thermal anomaly than /N. Comparatively strong temperature-dependence of the heat capacity is suggested in RN. All these findings support the picture of competing incommensurate smectic periodicities and the phenomenological optimum density theory.

抄録全体を表示

Background: Doxorubicin (D) is a potent antineoplastic agent; however, hepatotoxic events are significant hurdle in cancer patients with liver disease. The overproduction of reactive oxygen species is considered as a significant cause of this side effect. The aim of our study was to evaluate the potential hepatoprotective properties of bile acid an ursodeoxycholic acid (U), through its influence on lipid peroxidation (LPO) and expression of glutathione-dependent antioxidative enzymes in the livers of rats treated with D.

Methods: 24 male Wistar rats were divided in four groups. Animals were administered with vehicle (saline i.p. (K1), saline i.p. with propylene glycol p.o. (K2)), D (3 mg/kg i.p. every other day for 3 doses) or combined U 25 mg/kg p.o. every other day for 3 doses, starting one day before D. After four weeks animals were euthanized and the livers were used for analysis of oxidative stress.

Results: In the livers of animals administered with D, LPO was increased compared to both control groups, whereas in DU group the intensity of LPO was decreased, closely to control values. Treatment with D significantly increased the specific activities of glutathione peroxidase (GPx) compared to control groups (p<0.01 vs.K1 and K2). Combined treatment with D+U decreased GPx activity. Similarly, the activity of glutathione reductase was highest in group D and lower in group DU. Specific activity of glutathione-S-tranferase was significantly increased in D-treated group compared to controls (p<0.05 vs. K1 and K2), and decreased in DU group, however without statistical significance.

Conclusions: Ursodeoxycholic acid reduces expression of markers of oxidative stress representing thus an agent with potentially hepatoprotective properties during doxorubicin treatment. Acknowledgment: Supported by HORIZON2020 MEDLEM project No. 690876, and the Project for Scientific and Technological Development of Vojvodina No. 114-451-2072-/2016-02 and project of Ministry for education, science and technological development of the Republic of Serbia, grant III41012.

抄録全体を表示

Following sinoaortic denervation () rats present intense arterial pressure lability without sustained hypertension. This study aimed to verify the effects of heptanol (a putative gap-junction blocker) and tetraethylammonium (TEA, a putative gap-junction activator) on rhythmic contractions (RCs) and vascular reactivity in the aortas isolated from and Sham-operated (SO) rats. Rhythmic contractions were observed with phenylephrine in endothelium-removed aortic rings from rats. We evaluated the effects of the gap-junction modulators heptanol or TEA on the frequency and amplitude of these oscillations. Additionally, concentration–response curves were constructed to TEA and KCl and in pre-contracted arteries (with phenylephrine or KCl) to heptanol in order to verify the effects of those gap-junction modulators. Comparatively, rhythmic contractions were observed in 10/10 rat aortas vs. 2/10 controls. Heptanol decreased the frequency of oscillations in a concentration-dependent manner. TEA increased the amplitude and frequency of RCs. In the experiments of concentration–response curves to TEA, the maximal contractile effect was similar in both groups, although the potency was lower in than in SO rat aortas. The relaxation to heptanol was different between the groups only after pre-contraction induced by phenylephrine. Heptanol showed higher potency in as compared to SO rat aortas. In conclusion, arterial pressure lability occurs only in rats, and their isolated aortas exhibit intense RCs. These RCs seem to be dependent of the gap-junction communication, since these oscillations are intensified by TEA and inhibited by heptanol. After , aortas are more sensitive to heptanol and less sensitive to TEA.

抄録全体を表示

社交不安症（障害）（）は，社会的状況に対する過度でコントロールできない恐怖または不安が生じ，そのためそのような状況を回避し，著しい社会機能障害を呈する不安症である。本稿では，の薬物療法について，最近の知見を中心に述べる。メタ解析やRCTによるエビデンスによると，の薬物療法としては，SSRIとSNRI, そしてRIMAがプラセボに比し有意に効果があるとされている。しかしながらわが国ではRIMAは使用できない。また最近承認され，に最もエビデンスがあるSNRIであるベンラファキシンもへの保険適応がないことから，わが国でのの薬物療法の中心は，現時点ではSSRIとなろう。

抄録全体を表示

本研究では，拒絶過敏性の下位因子と社会的スキルが社交不安症状（Social Anxiety Disorder （

）症状）に及ぼす影響を検討した。健常大学生（N = 186）を対象に質問紙調査を行った。相関分析の結果，症状と拒絶過敏性の下位因子の間に正の相関，社会的スキルと拒絶過敏性の下位因子，症状との間に負の相関がみられた。拒絶過敏性の下位因子，社会的スキルを予測変数，症状を目的変数とした重回帰分析の結果，関係破綻の不安と社会的スキルが症状に及ぼす影響は共に有意だった。共分散構造分析の結果，関係破綻の不安と他者評価追従は直接症状に影響を及ぼし，社会的自己像と真の自己像の不一致と他者評価追従は社会的スキルを媒介して症状に影響を及ぼすことが示された。本研究の結果から，拒絶過敏性の下位因子により症状に影響を及ぼすプロセスが異なることが明らかとなった。

抄録全体を表示

Variable block size motion estimation developed by the latest video coding standard H.264/AVC is the efficient approach to reduce the temporal redundancies. The intensive computational complexity coming from the variable block size technique makes the hardwired accelerator essential, for real-time applications. Propagate partial sums of absolute differences (Propagate Partial ) and

SAD

Tree hardwired engines outperform other counterparts, especially considering the impact of supporting variable block size technique. In this paper, the authors apply the architecture-level and the circuit-level approaches to improve the maximum operating frequency and reduce the hardware overhead of Propagate Partial and

SAD

Tree, while other metrics, in terms of latency, memory bandwidth and hardware utilization, of the original architectures are maintained. Experiments demonstrate that by using the proposed approaches, at 110.8MHz operating frequency, compared with the original architectures, 14.7% and 18.0% gate count can be saved for Propagate Partial and

SAD

Tree, respectively. With TSMC 0.18µm 1P6M CMOS technology, the proposed Propagate Partial architecture achieves 231.6MHz operating frequency at a cost of 84.1k gates. Correspondingly, the maximum work frequency of the optimized

SAD

Tree architecture is improved to 204.8MHz, which is almost two times of the original one, while its hardware overhead is merely 88.5k-gate.

抄録全体を表示