Due to the improvements in the production process for metal injection molding (MIM) parts produced by this method, especially light weight parts with very complex shape have become very competitive against other technologies. The introduction of the catalytic debinding process is an important improvement since it decreases the debinding time greatly and allows the use of a continuous process, in which debinding as well as sintering is performed in one furnace. MIM parts for automotive applications can be found increasingly at least on the European market.

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An index that can mutually evaluate the navigation performance of ships of different sizes will promote an introduction of vessels with excellent navigation efficiency. In this study, the Energy Efficiency of Navigational Indicator (EENI) and the energy efficiency of propulsion indicator (Kn) were introduced to compare the operating performance of coastal vessels with each other. A methodology using the bootstrap was introduced to accurately identify curves of these indicators even with a small sample, because the number of coastal vessels is small. This methodology was applied to the results of sea trials of 16 coastal cement and limestone ships, and the relationship between ship energy efficiency and displacement was clarified.

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The synthesis of a series of 7-acylamido cephalosporins having a substituted furyl moiety
in the side chain is described. These new cephalosporins were examined in vitro for antibacterial
activity and evaluated for resistance to inactivation by β-lactamases.

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A series of new 7-acylamidocephalosporins, containing a substituted naphthalene moiety
in the side chain, has been prepared and tested for their in vitro antibacterial activity. Some
observations are made on the structure-activity relationships.

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Coffee attracts consumers worldwide for its unique sensorial properties. Its unique flavor is affected by numerous factors. The biochemical properties associated with geographical features are among the essential aspects that may modulate coffee’s distinct sensorial profiles, and may be employed for its origin determination and authentication. This systematic literature review served to assess the newest techniques for coffee authentication, origin determination, and adulteration detection from analytical and nondestructive approaches. This study focused on the last 10 years’ high-quality research in the field. Accordingly, 78 articles using both analytical and nondestructive methods for the determination of coffee origin and fraud detection were found in leading journal databases. Apart from the compound profile and instrumentation, data analyses including statistics, machine learning, and multivariate models which have been commonly used are discussed as well. In addition, other important information, such as data validation methods and the predictive capability of the above techniques are also reflected in this review.

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本研究では, 種々の形状をした防雪柵まわりの流れ場と雪の堆雪形成過程を数値シミュレーションにより調べ, 柵形状が流れ場および堆雪形状に対してどのような影響を及ぼすか, 定性的・定量的に見積もることを目的としている.計算方法は (1) 防雪柵まわり流れ場の計算, (2) 雪の拡散計算, (3) 風による積雪輸送の計算, (4) 雪面形状変化の計算の4段階からなる. (4) により計算領域の形状が変化するため, 時間的発展と共にこれらの各ステップを繰り返す必要がある.
流れ場の計算は, 差分法を用いて非圧縮性ナビエ・ストークス方程式を数値的に解くことにより行った.ただし, 領域形状は雪面に凹凸があるため複雑であることそして複雑な形状をもつ防雪柵も取り扱うため, 一般座標を用いて境界に適合する格子上で計算を行った.この点が従来の計算ともっとも大きく異なる点である.雪の拡散は移流拡散方程式を数値的に解くことにより求めた.雪面形状の変化は降雪および一度積った雪が風により輸送されることによりおこる.前者については落下する雪粒子に対する運動方程式を解くことにより, また後者は風による表面摩擦と雪の輸送量の関係から見積もることができる.そして, その結果を用いて雪面上の微小領域における質量保存則から雪面形状を決定した.
このような計算方法を用いて3次元の解析を行った.本研究では基本的な柵として直立密閉柵, 一般座標の特徴を生かした応用例として忍び返し密閉柵, 傾斜密閉柵そして傾斜面における直立密閉柵の合計四種類の防雪柵を選び, 流れ場および堆雪形状を計算してその有効性を調べた.その結果, 複雑な地形, 複雑な防雪柵に対しても定性的傾向は雪面の景観と一致しており, 一般座標を用いた3次元流れの数値シミュレーションは基本的に有効であると判断した.

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Recently, metabolomics has grown rapidly in the fields of food and agriculture. Complex physiological changes after harvest prompted the development of a new metabolomic analytical method offering more profound insight into these changes. This review presents the feasibility of a metabolomics approach to elucidate physiological changes during ripening, senescence, and disorders. Additionally, we introduce metabolomics for the authentication of agricultural products. Confirmation of species, varieties, and geographical origin via metabolomics can be useful to tackle adulteration and certify quality.

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  A method is presented which allows for the nondestructive measurement of the new parameter KH50 which characterizes both the coercive force Hc and Mrt for magnetic disc. The technique involves the application of reference erasing magnetic field on previously written sequence of pulses with subsequent KH50 calculation which is the ratio of track average amplitudes (TAA) of readback pulses after and before erasing. Reference Disc specification by additional calibration factor KH50 allows for to define a Secondary Standard Reference Surfaces (SSRS) [1] with much closer to Standard Reference Surface (SRS) magnetic properties and therefore to increase magnetic disc performance measurement accuracy.

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Polycyclic aromatic compounds possessing heteroatoms are one of the most important materials for organic electronics. Because of the lack of a suitable synthetic methodology, only a few polycyclic aromatic compounds with ring junction heteroatoms, heteroatom-doped nanographenes, have been synthesized to date, even though theoretical investigations have suggested that those molecules are attractive not only as the electronic materials but also as substructures of heteroatom-doped nanocarbons. Herein, we describe development of novel tandem hetero-Friedel-Crafts reactions and their application for the synthesis of heteroatom-fused polycyclic aromatic compounds. These compounds showed strong luminescence or carrier transport ability, thus can be a promissing class of organic materials for optelectronic devices. We have demonstrated their potential utility by fablicating phosphorescent organic light-emitting diodes with a sufficiently high efficiency and a long device lifetime.

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先に開発した5nm分解能小型超精密位置決め装置（機構的粗微動なし）と同一原理の1nm分解能小型超精密位置決め装置を開発した。これは機構的にマイクロステッピングモータ、減速機、ボールねじ、リニアころガイドより成る。PTP方式位置決めでは、モータを高速（開ループ）、中速（閉ループ）、低速（閉ループ）で駆動し、1nm分解能変位センサによるフィードバック制御を適用し、ステージを目標位置の±1nm以内に停止できた。

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In this paper, we describe a thennal control of a thermoelectric cooler / heater with Peltier device which is operated by the Peltier Effect. Generally, it is said that the thermal control with Peltier device is difficult because of its nonlineariry. In order to deal with the nonlinearity, we use nonlinear model predictive control for the thermal control of the device. A nonlinear model of the thermal system with Peltier device is derived. The validity of the model is evaluated by experimental results. Nonlinear model predictive control system is designed for the model. Recursive Kalman filter is used to estimate the unobservable state variables. The experimental results show the accurate control performance. The robustness against themal load is also verified by the experiments.

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DNA arrays have been successfully used for gene expression profiling of cells at the mRNA level. However, it has certain limitations: since there is not always a direct correlation between mRNA levels and protein expression (Gygi etal, 1999). Gene expression profiling may not represent the actual cellular proteome. Antibody arrays, which are a relatively new technology, are used to profile directly protein expression. They enable the researcher to profile hundreds of proteins and their post-translational modifications. Samples are not restricted to tumor cells and tissues but can be also biological fluids. In the last few years, researchers have developed several different antibody arrays. The common principle of this technology is based on the highly specific recognition between an antibody and its target antigen combined with miniaturization for high throughput screening. In this technology, antibodies are printed on a solid support, and the sample, usually containing a mixture of proteins, is applied on them. The interaction between the antibody and its specific antigen is then visualized by a choice of various detection methods. Identifying the proteins' changes may lead to the discovery of cancer-associated biomarkers that may assist in diagnosis, prognosis, patient monitoring and possibly for therapeutic purposes. Antibody arrays are a relatively new technology that enables one to perform multiplex high-throughput protein expression profiling. In this symposium, I will show the technical advances in slide-based antibody array and their application for biomarker identification within different cancers.

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Due to the nature of cavitation numerical analyses, computational optimization of a pump with respect to the cavitation properties is extremely demanding. In this paper it is shown how a combination of Transient Blade Row (TBR) method and some simplifications can be used for making the optimization process more efficient and thus possible on current generation of hardware. The aim of the paper is not the theory of hydraulic design. Instead, the practical aspects of numerical optimization are shown. This is done on an example of a radial pump and a combination of ANSYS CFX, ANSYS software tools and custom scripts is used. First, a comparison of TBR and fully-transient simulation is made. Based on the results, the TBR method is chosen and a parametric model assembled. Design of Experiment (DOE) table is computed and the results are used for sensitivity analysis. As the last step, the final design is created and computed as fully-transient. In conclusion, the results are discussed.

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This paper deals with the CFD analysis of cavitating flow in the mixed-flow pump with the specific speed of 1.64 which suffers from a high level of noise and vibrations close to the optimal flow coefficient. The ANSYS CFX package has been used to solve URANS equations together with the Rayleigh-Plesset model and the SST-SAS turbulence model has been employed to capture highly unsteady phenomena inside the pump. The CFD analysis has provided a good picture of the cavitation structures inside the pump and their dynamics for a wide range of flow coefficients and NPSH values. Cavitation instabilities were detected at 70% of the optimal flow coefficient close to the NPSH3 value (NPSH3 is the net positive suction head required for the 3% drop of the total head of the pump).

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The automation of machining hole surface inspection where visual observation is difficult has been remained as a large problem in the factory for producing car parts etc. Our development has enabled it by means of the industrial robot which is equipped with the laser surface inspection instrument "ANALYZERR^<[○!R]>". The inspection robot system for machining hole surface will be possible to apply random-placed parts or conveying parts. A usefulness of the developed inspection robot system is revealed in this report.

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Neuroactive neurosteroids, including progesterone, allopregnanolone, pregnenolone and dehydroepiandrosterone, represent steroid hormones synthesized de novo in the brain and acting locally on nervous cells. Neurosteroids modulate several neurotransmitter systems such as γ-aminobutyric acid type A (GABA_A), N-methyl-D-aspartate (NMDA) and acetylcholine receptors. As physiologic consequences, they are involved in neuronal plasticity, learning and memory processes, aggression and epilepsy, and they modulate the responses to stress, anxiety and depression. The -receptor protein was recently purified and its cDNA was cloned in several species. The amino-acid sequences are structurally unrelated to known mammalian proteins, but shared homology with a fungal sterol C₈-C₇ isomerase. The -receptor ligands exert a potent neuromodulation on excitatory neurotransmitter systems, including the glutamate and cholinergic systems. Consequently, selective agonists show neuroprotective properties and beneficial effects in memory processes, stress and depression. The evidence of a direct interaction between neurosteroids and receptors was first suggested by the ability of several steroids to inhibit the binding of -receptor radioligands in vitro and in vivo. A crossed pharmacology between neurosteroids and -receptor ligands was described in several physiological tests and behavioral responses. This review will detail the recent evidence for a common mechanism of action between neurosteroids and -receptor ligands and focus on the potential therapeutic interests of such interaction in the physiopathology of learning and memory impairments, stress, depression and neuroprotection.

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