Sticker has once published an opinion that lepra bacilli can penetrate the nasal mucous membrane: but so far, no experiment has ever been attemped to confirm this opinion. The writer, therefore, made the following experiment:
In three rabbits and three mice, the author poured lepra tubercle emulsion into the nasal cavity for 30 minutes. In one of the rabbits, the author dropped the emulsion into the nasal cavity combined with pouring into the conjunctival sac. The emulsion thus dropped into the conjunctival sac reached the nasal cavity through the nasolachrymal duct. In 1250 microscopic sections of the nasal mucoua, the author recognized 37 lepra bacilli in not only the shallow layer direct beneath the mucous membrane and near the gland, but also in the walls of blood vessels. In other words, the author ascertained that lepra bacilli passes through the nasal mucous membrane without any pathological change.
The writer has so far made seven series of experiments concerning the penetration of the lepra bacilli, the results of which were reported in No. 2 of Volume 6, No. 2 of
Volume
7
, and No. 5 of
Volume
7
of this paper. The reports may be summerrized as below:
According to the writer's experiments, the bacilli intrusion comes in percentage in the following order:
The highest is the wounded skin, the second is the hair extracted skin, the third is the case where the emulsion was rubbed into the skin and the fourth is the mucous membranes of the eyelid and nostril, finally the healthy skin being the lowest in percentage.
As the results of experiments mentained above the writer does not deny as the Sticker's statement that lepra bacilli intrudes through the nasal mucous membrane.
But the writer cannot entirely agree with Sticker's view so as to the lepra bacilli penetrate mostly through the nasal mucosa. The author, therefore, might make here my own view point, that the lepra bacilli might penetrate mostly through the wounded skin.
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