Hemorrhagic fever with renal syndrome (HFRS) is highly endemic in mainland China, where human cases account for 90% of the total global cases. City is one of the most seriously affected areas in Shandong Province, China. Therefore, there is an urgent need for monitoring and predicting HFRS incidence in to make the control of HFRS more effective. In this study, we constructed an autoregressive integrated moving average (ARIMA) model for monthly HFRS incidence in from 2004 to 2013. The ARIMA (3,1,1) × (2,1,1)₁₂ model is reliable with a high validity, which can be used to predict the next year's HFRS incidence in . The forecast results suggest that the HFRS incidence in will experience a slight growth in the next year.

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We found a highly dolomitic lamprophyre diatreme at Badou, Shandong province, China for the first time. Although a number of silicate-rich carbonatite and glimmerite dikes and sheets were found around Badou, no alkaline rock–carbonatite plutonic complex exists nearby. Dolomitic lamprophyre diatreme that is not related with plutonic complex is not known yet either, and this is the first report of such an unusual occurrence. We report the whole-rock major and trace element chemistries of the lamprophyric rocks. The rocks consist of dominant dolomite with associated phlogopite, clinopyroxene, olivine, apatite and carry a number of xenoliths. Judging from all the geochemical and mineralogical data, the rock from Badou pipe should belong to the group of ultramafic lamprophyre and, more strictly, it should be called melnoite defined by Mitchell (1994).¹⁾ This finding should contribute to the understanding of the origin of carbonatite magma and the relationships between carbonatite and silicate magmas.


(Communicated by Ikuo KUSHIRO, M.J.A.)

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A cooperative control of two robots by remote operation is proposed in this paper. The two slave robots are controlled simultaneously by another remote master robot that is manipulated by a human operator. Force-reflection bilateral control method is adopted in the master and slave robots control to make the operator manipulate the robots smoothly. In order to make the two slave robots act cooperatively to catch, carry and set an object two methods of hybrid control and impedance control are used and compared to control the two slave robots.

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Shandong Province is located in the east of China, and its tourism resources are unique. The 17 prefecture-level cities in Shandong Province have formed different regional labels due to the diversity of topography and landforms and the differences in history and culture. This paper summarizes the tourism resources and their characteristics in Shandong Province, including (1) the general situation of tourism resources in 17 prefecture-level cities, and (2) the characteristics of tourism resources. This paper has a certain academic value for optimizing the space of tourism development, deeply excavating the characteristics of tourism resources, and speeding up the formation of a new pattern of tourism development.

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Urban land expansion is the closest representation of urbanization in spatial dimension, and is one of the most important factors affecting land-use/cover change on a regional scale. China has experienced rapid urban growth, which can be monitored by the Landsat TM digital images. This paper measures urban land expansion in China using the high resolution Landsat TM digital images in three periods, 1989/1990, 1995/1996 and 1999/2000, and identifies four types of urban land expansion, namely neighborhood, axis-based, pole-based and multi-nucleus expansion which coexisted in the 1990s. The urban land expansion in China totals 817 thousand hectares, among which the expansion during the first half (1990-1995) is more than four times that of the latter half. This paper identifies the main factors contributing to the formation of the four types of urban expansion patterns based on cases studies of Beijing, Guangzhou, Shanghai and , and gives a detailed account of the driving forces of urban land expansion in the 1990s.

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The microstructure of 1 mol % calcia-doped yttria under different sintering condition was investigated, and the thermal shock resistance of yttria with and without additive was compared in present work. The results showed that by adding 1 mol % calcia, the sinterability of yttria is greatly improved and the sample can be sintered as low as 1300°C. Increasing heating temperature and prolonging soaking time are beneficial to form coarse grains with lots of closed pores in calcia-added sample at temperatures higher than 1500°C. By theoretical analysis, it is known that because of the solid solution of Ca²⁺, defects are generated in the yttria lattice, and the activation energy for diffusion is decreased. Therefore, the grain boundary mobility of yttria is accelerated and closed pores are left inside coarse grains when pores cannot move with yttria grain boundaries anymore. The water quench test reveals that the non-additive sample heated at 1500°C has the highest thermal shock resistance and it cannot be utilized under high temperature in industry. On the contrary, the calcia-doped sample has superior thermal shock resistance by the effect of closed pores, and it might be utilized to melt and cast high purity titanium and its alloys through vacuum induction melting (VIM) process.

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The eastern Tethyan fusulinacean faunas are best represented by Chinese examples. They are taxonomically much more diverse than those reported from outside China, particularly those of the Middle and Late Permian. Some fusulinaceans characteristi cof China are kept in the Museum of Nature and Human Activities ,Hyogo, Japan. They are available for comparative fusulinacean studies between China and sources outside China. Fusulinaceans contained in 130 pieces of limestone thin sections, prepared in China, range from Bashkirian (lowest Upper Carboniferous) to Changhsingian (uppermost Permian). Some photomicrograhs of their limestone petrologies and well-oriented fusulinaceans are included herewith, to illustrat easpects of the present materials, in addition to brief notes on thei rgeographic and biogeographic distribution sL.imestone petrology and foraminiferal faunal composition of each are shown in appendix.

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Resistance to docetaxel is a major problem to the success of docetaxel-based therapies for breast cancer. The present study was to identify the role of circABCB1 in altering the docetaxel resistance properties. Reverse transcription-quantitative PCR (qRT-PCR) was performed to quantify circABCB1 and miR-153-3p. The effects of circABCB1 on the viability, apoptosis and migration/invasion of docetaxel-resistant and -sensitive cells were investigated by cell function experiments, including Cell Counting Kit-8 and Transwell assays. Correlation between circABCB1 and the docetaxel-treated outcome was analyzed by multivariate Cox regression analysis, in addition to Kaplan-Meier analysis of time to treatment failure (TTF). The targeting relationship between circABCB1 and miR-153-3p was predicted and verified by dual-luciferase reporter assay and RNA immunoprecipitation. CircABCB1 was highly expressed in cancerous tissues, as well as the docetaxel-sensitive group and cells. The overexpression of circABCB1 contributed to cell viability, docetaxel-resistance and migration/invasion, but inhibited apoptosis. CircABCB1 can sponge miR-153-3p. CircABCB1 contributed to the docetaxel resistance of breast cancer, maybe via the miR-153-3p.

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Objective: In order to find problems and provide reference for the standardization of application of Morita therapy in China, we preliminarily investigated the overview of how Morita therapy was taken in China. Object and method: Questionnaire survey was performed to inquiry eight representative medical institutions which had department of psychiatry by sending e-mail and assigning person during half year. The questionnaire was completed by psychiatric physicians. Result: During the half year, all medical institutions have adopted Morita therapy and used the method of diary therapy, and accompanied drugs. In the clinic Morita therapy, the maximum frequency was up to 20 times during a session, while the general was between 4 to 20 times. The longest treatment period per time of Morita therapy was 1 to 2 hours accounting for 62.5% of all institutions. 25% took 40 to 60 minutes per time. And 12.5% took about 30 minutes each time. In the resident Morita therapy, it was different in the treatment period of each session and the treatment method among the eight institutions. Discussion: The results indicated that Morita therapy did have been widely used and developed in some extent in China. But the survey also showed that the standard of Morita therapy in China varied and the concept was not uniform. This may be because that mental illness itself is a behavioral disorder which is difficult to strictly distinguish and there is no strict period division in Morita therapy, as well as the level of awareness on Morita therapy varies from physician to physician. Herein, it's necessary to carry out more training on Morita therapy and invite professional Japanese experts to lecture in China. The popularization of Morita therapy has practical significance.

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Aims: The protective effects of hawthorn fruit against atherosclerosis and the potential underlying mechanisms of this fruit in improving the hypolipidemic and antioxidant activities were investigated in apolipoprotein E-deficient(apoE^−/−) mice.
Methods: ApoE^−/− mice were divided into a control group(n=10) and hawthorn fruit group(n=10). The mean size of the lesions in the aortic root was assessed, and the serum glucose levels, insulin levels, lipid profiles, total antioxidant capacity(T-AOC) and superoxide dismutase(SOD) and glutathione peroxidase(GSH-PX) activities were measured. The mRNA levels of hepatic genes related to lipid metabolism and antioxidant enzymes were examined.
Results: The hawthorn fruit group mice developed significantly decreased(p＜0.05) atherosclerotic lesions. The levels of serum lipids decreased significantly(p＜0.05) and the levels of cholesterol/triglycerides, including very-low-density lipoprotein(VLDL) and low-density lipoprotein(LDL), decreased in the hawthorn fruit group. The hawthorn fruit mice exhibited significantly increased T-AOC values and SOD and GSH-PX activities(p＜0.05). The hepatic fatty acid synthase(FAS) and sterol regulatory element binding protein-1c(SREBP-1c) mRNA levels were reduced by 42%(p＜0.05) and 23% p＜0.05) in the mice fed the hawthorn fruit diet compared with that observed in the mice fed a standard diet. However, the hepatic hydroxymethylglutaryl CoA reductase(HMG-CoAR) mRNA levels showed no significant differences between the two groups. The mRNA expression levels of the antioxidant enzymes(SOD1, SOD2, Gpx3) were higher(p＜0.05) in the livers of the hawthorn fruit diet mice compared with those observed in the control mice.
Conclusions: Hawthorn fruit exerts a protective effect against atherosclerosis in apoE^−/− mice by improving the hypolipidemic and antioxidant activities.

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Ovarian cancer (OC) is one of prevalent tumors and this study aimed to explore CCL20’s effects on doxorubicin resistance of OC and related mechanisms. Doxorubicin-resistant SKOV3 DR cells were established from SKOV3 cells via 6-month continuous exposure to gradient concentrations of doxorubicin. Quantitative PCR and Western blot assay showed that SKOV3 DR cells had higher level of CCL20 than SKOV3 cells, and doxorubicin upregulated CCL20 expression in SKOV3 cells. MTT and cell count assay found that CCL20 overexpression plasmid enhanced doxorubicin resistance of SKOV3 and OVCA433 cells compared to empty vector, as shown by the increase in cell viability. In contrast, CCL20 shRNA enhanced doxorubicin sensitivity of SKOV3 DR cells compared to control. CCL20 overexpression plasmid promoted NF-kB activation and positively regulated ABCB1 expression. Besides, ABCB1 overexpression plasmid enhanced the viability of SKOV3 and OVCA433 cells compared to empty vector under treatment with the same concentration of doxorubicin, whereas ABCB1 shRNA inhibited doxorubicin resistance of SKOV3 DR cells compared to control. In conclusion, CCL20 enhanced doxorubicin resistance of OC cells by regulating ABCB1 expression.

Key words: CCL20, ovarian cancer, doxorubicin resistance, tumor-promoting, ABCB1

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A prenatal sonograph revealed a 26-week-old fetus with short limbs and a narrow chest in a 23-year-old woman with a history of fetal skeletal dysplasia. A single nucleotide polymorphism-based chromosomal microarray (CMA) indicated a normal karyotype, and no chromosomal segments with abnormal copy numbers were noted in the fetus. Whole exome sequencing identified compound heterozygous mutations in the DYNC2H1 gene responsible for a lethal type of bone growth disorder, short-rib thoracic dysplasia 3 with or without polydactyly (SRTD3), and revealed a missense mutation c.515C>A (p. Pro172Gln) of paternal origin and a missense mutation c.5983G>A (p. Ala1995Thr) of maternal origin. These variants were further confirmed by Sanger sequencing. To the extent known, the c.515C>A (p. Pro172Gln) mutation is novel for SRTD3, and the site is conserved across species. This study found a novel mutation of the DYNC2H1 gene for SRTD3 and it has increased the number of reported cases and expanded the spectrum of mutations causing this rare disease.

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Al₂O₃–SiO₂ aerogel was prepared through mixed sol–gel process and ethanol supercritical drying technology using aluminum chloride hexahydrate (AlCl₃·6H₂O) and tetraethoxysilane (TEOS) as precursors. Under the condition of the propylene oxide used as gelation initiators, during the process, a kind of Al₂O₃–SiO₂ aerogel with porous and large specific surface area were achieved in our experiments. Structures and properties of Al₂O₃–SiO₂ aerogel are investigated by means of X-ray Diffraction, Nitrogen adsorption/desorption analysis, Scanning Electron Microscopy, Fourier Transform Infrared Spectroscope, and Thermogravimetry-Differential Thermal analysis. The results showed that the Al₂O₃–SiO₂ aerogel with the mole ratio of Al/Si = 3/1 possessed better heat-insulation performance and high-temperature stability. And it possessed a porous network structure made up of leaf shape particles. At the same time, Al₂O₃–SiO₂ aerogel showed a low density of 0.071 g/cm³ at room temperature, specific surface areas of 708 m²/g at 600°C, as well as 255 m²/g at 1200°C. The Al₂O₃–SiO₂ aerogel is the polycrystalline boehmite (γ-AlOOH) phase at room temperature. As the temperature growing, it transferred to γ-Al₂O₃ at 600°C, and mullite phase at 1200°C.

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The measurement of total bilirubin in serum is one of the most frequently performed tests in clinical analysis. A new spectrofluorometric method was developed for the determination of trace amounts of total bilirubin. Using tetracycline-Eu³⁺ as a fluorescent probe, bilirubin can remarkably reduce the fluorescence intensity of the tetracycline-Eu³⁺ complex, and the reduced fluorescence intensity of Eu³⁺ ion is in proportion to the concentration of bilirubin. The optimum conditions for the determination of bilirubin were also investigated. This method is simple, practical, and relatively free of interference from coexisting substances. It can be successfully applied to assess total bilirubin in serum samples. We also compared the developed method with a modified Jendrassik-Grof method in clinical analysis.

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A serosurvey of severe fever with thrombocytopenia syndrome virus (SFTSV) infection in domestic animals was conducted in the rural areas of Laizhou City, Shandong Province, China to determine strategies for control and prevention of SFTS. Serum samples were collected from cattle, goats, dogs, pigs, and chickens and antibodies against SFTSV were detected by double-antigen sandwich enzyme-linked immunosorbent assay (ELISA). Of 641 serum samples, the SFTSV seropositive rate was 41.8% (268/641): 74.8%, 57.1%, 52.1%, 35.9%, and 0%, for goats, cattle, dogs, chickens, and pigs, respectively. We also found that the SFTSV seropositive rates were high among the aged cattle, goats, dogs, and chickens. SFTSV infections existed among cattle, goats, dogs, and chickens in Laizhou City, and goats had the highest seroprevalence. SFTSV seroprevalence increased with an increase in age among animals. To control of animal infestation with ticks may prevent human SFTSV infections.

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Sustainable renewable energy is being hotly debated globally because the continued use of finite fossil fuels is now widely recognized as being unsustainable. Microalgae potentially offer great opportunities for resolving this challenge. Abscisic acid (ABA), jasmonic acid (JA) and salicylic acid (SA) are involved in regulating many physiological properties and have been widely used in higher plants. To test if phytohormones have an impact on accumulating lipid for microalgae, ABA, JA and SA were used to induce two Chlorella strains in the present study. The results showed 1.0 mg/L ABA, 10 mg/L SA, and 0.5 mg/L JA, led strain C. vulgaris ZF strain to produce a 45%, 42% and 49% lipid content that was 1.8-, 1.7- and 2.0-fold that of controls, respectively. For FACHB 31 (number 31 of the Freshwater Algae Culture Collection at the Institute of Hydrobiology, Chinese Academy of Sciences), the addition of 1.0 mg/L ABA, 10 mg/L SA, and 0.5 mg/L, JA produced 33%, 30% and 38% lipid content, which was 1.8-, 1.6- and 2.1-fold that of controls, respectively. As for lipid productivity, 1.0 mg/L ABA increased the lipid productivity of C. vulgaris ZF strain and FACHB-31 by 123% and 44%; 10 mg/L SA enhanced lipid productivity by 100% and 33%; the best elicitor, 0.5 mg/L JA, augmented lipid productivity by 127% and 75% compared to that of controls, respectively. The results above suggest that the three phytohormones at physiological concentrations play crucial roles in inducing lipid accumulation in Chlorella.

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