This paper outlines a mathematical description of the stress dilatancy behaviour of granular materials which accounts for stress level and void ratio dependencies. The consideration of these aspects has important implications in the modelling of granular material behaviour. In fact, granular material mechanical response is largely dominated by the evolution of dilatancy, fabric and void ratio histories. The starting point in this study is the well established Rowe's theory which is revisited and ultimately modified by introducing a factor linked to governing state parameters in order to describe the complete behaviour of granular materials during deformation. Numerical simulations of triaxial tests on granular materials at different void ratios and stress levels are herein presented to illustrate the model.

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A structure analysis of has been carried out to determine the deuterium trap sites by neutron powder diffraction with the Rietveld profile analysis. It is revealed that the deuterium atoms are located at octahedral () sites surrounded by six Ti atoms in the crystal structure of , space group P6₃/mcm. Local vibration spectra of hydrogen in measured by neutron inelastic scattering support this result; the energy eigenvalue of the primary vibration mode is found at .53 kJ/mol (78 meV). The hole radius and the spring constant of the Ti-H() bond are discussed.

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A boron treated copper bearing HSLA steel containing austenite formers like manganese and nickel, somewhat lower in amount than that in HSLA 100 variety of steel is chosen for the study. The role of thermomechanical processing on the microstructure and mechanical properties of the above steel has been investigated. Differential scanning calorimetric study is carried out for understanding the precipitation behaviour of copper in HSLA steel under the influence of boron. The microstructure of the experimental steel is found to consist of laths of martensites and bainite. MA constituents of ribbon like morphology are observed at the lath boundaries. Higher strength properties of the steel are attributed to the presence of finely distributed precipitates of copper and microalloy carbides.

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The possibility of attenuation of microseismic waves due to the presence of an upward folding of the ocean bottom into the liquid is discussed in this paper. The upward folding of the ocean bottom has been idealized by means of an irregularity in the form of a rectangle intruding into the liquid and the evaluation of the displacement component at any point of the solid medium has been carried out in two stages. First, the change in the incident mode of the surface wave due to the presence of the rectangular irregularity has been determined, and second, the subsequent change of the resulting displacement components due to the termination of the liquid layer and the step change in elevation of the solid medium at the continental margin has been discovered. Finally, numerical calculation has been made to determine the attenuation of the microseismic waves of different periods due to the presence of the rectangular irregularity at the ocean bottom.

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We screened the differentiation-inducing activities of 39 mushroom extracts from Akita prefecture, Japan, on the mouse osteoblastic cell line, MCT-1. Sixteen phosphate buffered saline (PBS), 8 boiled PBS, 14 ethanol and 12 methanol extracts induced alkaline phosphatase (ALP) activities, an indicator of MCT-1 cell differentiation. The enzyme activities were markedly induced by extracts of Tricholoma auratum, and we isolated the active compound from methanol extracts of this mushroom. Physical data for the isolated active compound were identical to those for (,24R)-ergosta-,-diene-,,6β-triol (1). 1 induced ALP activities of MCT-1 cells and promoted cell proliferation. To investigate the relationships between the chemical structure and differentiation-inducing activity of the compound, ALP-inducing activities of MCT-1 cells by 1, ergosterol (2), ergocalciferol (), cholesta-,,6β-triol (4), -dehydrocholesterol () and cholecalciferol (6) were tested. The enzyme activities of MCT-1 cells were increased .-fold by 10 μM 1 and 2.4-fold by 10 μM 4. However, 2, , and 6 did not induce MCT-1 cell ALP activity at .1—10 μM. These results suggested that the OH groups at C- and/or C-6 of 1 and 4 played an important role in their differentiation-inducing activities on MCT-1 cells. Furthermore, 1 suppressed induction of MCT-1 cell apoptosis by serum starvation.

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One method currently being considered for the disposal of high level radio-active waste is burial in the seabed. When a hot object is buried in soil, the temperature of the soil adjacent to the object is raised and there is transient heat flow away from the object. The rise in the temperature of the soil causes excess pore pressures to be generated and transient pore water diffusion also takes place. A finite element formulation of the coupled heat flow and consolidation problem is presented. The computer implementation of this formulation is found to compare favourably with analytical solutions based on the same physical principles.

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The ability of Climacodon septentrionalis to immobilize and kill a mycophagous nematode (Aphelenchoides sp.) in vitro is described for the first time. Two isolates produced droplets (20–45 μm in diameter) that formed at the apices of tall, stalked, and branching secretory cells (700–1,500 μm tall). On 2% modified malt extract agar, nematodes became enveloped in the droplets, which restricted their ability to move and resulted in complete immobilization and death within several hours of contact. The rate of decomposition of the nematodes varied considerably, with most individuals persisting for weeks whereas others were degraded within several days and appeared to be colonized by dense hyphal growth. This study provides the first documentation of a non-agaricoid fungus producing secretory cells that are able to immobilize nematodes.

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This study aimed to determine the prevalence of fecal carriage of extended spectrum β-lactamase (ESBL) and/or plasmidic AmpC β-lactamase (pAmpC) producing Escherichia coli among dogs (n=428) in Turkey. Polymerase chain reaction (PCR) and sequencing were used to characterize genes encoding β-lactamase and plasmid mediated quinolone resistance (PMQR). Antimicrobial susceptibility testing and PCRs for virulence genes and phylogenetic groups were also performed. Cefotaxime resistant

. coli isolates were detected in 95 (.2%) of the swab samples. Sequencing analysis results showed occurrence of various β-lactamase genes: bla_CTX-M-15 (62), blaTEM-

1b

(42), bla_CMY-2 (

22

), blaCTX-M-

3

(16), bla_CTX-M-1 (15), bla_OXA-1 (

9

) and bla_SHV-12 (

3

) alone or in combination. The most frequently encountered phylogenetic group was group A₁ (35.8%), followed by group

D₂

(

22

.1%),

B

1 (15.8%),

D₁

(

9

.

5

%),

A₀

(

7

.4%),

B2₂

(

5

.

3

%) and

B2₃

(4.2%), respectively. PMQR genes, aac(6’)-Ib-cr, qnrS1 and qnrB10 were detected in 25.

3

, 10.

5

and 1.1% of the isolates, respectively. While all isolates were susceptible to imipenem and amikacin, resistance rates to non-β-lactam antibiotics ranged from 20.

0

% for tobramycin to 56.8% for tetracycline. The virulence genes were only detected in 34 (36.2%) of the isolates and this isolates carried single or various combination of virulence genes of iucD, papC, papE, f17a-A and eaeA. Four isolates were identified as human virulent pandemic CTX-M-15 producing

E

. coli clone O25

b

:ST131/

B

2. To the best of our knowledge, this is the first study to show fecal carriage of ESBL/pAmpC type β-lactamase producing

E

. coli isolates among dogs in Turkey.

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Clinical results of rotator cuff repairs using the same therapeutic exercises from an early stage after surgery were investigated and compared with the preoperative X-ray findings. 70 shoulders with rotator cuff tears treated operatively and followed by active-assistive exercises in a supine position from 1 week and active exercises standing from weeks after surgery were evaluated. The average age was 63 years old and follow-up periods were 11. months. The operative procedures were McLaughlin's method in 41 shoulders, side to side sutures in , acromioplasty in 17 and a tendon transfer in . The preoperative X-ray findings were classified into groups: group A, superiorly migrated humeral head and narrowed joint space in 4 shoulders; group , only superior migration in ; group C, only narrowed joint space in ; group , no changes in 36; group , subacromial spurs more than mm without superior migration in 20. The postoperative results were assessed according to the JOA score and the failure rate of each group was investigated. No significant differences in the preoperative JOA score were found in the groups. The postoperative JOA scores were 62.±.6 in group A, 75.1±12.6 in , 78.±12.2 in C, 90.4±. in , and .6±11.1 in . Especially groups and treated by McLaughlin's methods showed a significant higher score at follow-up. Rotator cuff repairs with the same therapeutic exercises from an early stage after surgery for groups A, and C showed poor results. Groups A and with a superior migration of the humeral head showed a high failure rate of 40 % compared with 4.% in group C, and with no superior migration. For these cases more careful postoperative exercises were recommended.

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The phase diagrams of the Ni-Mo- and Ni-W- ternary systems in the region of less than 50mol% were constructed by thermodynamic calculation, based on the data obtained by thermodynamic measurement of the related materials. We found three ternary eutectic points and three or two ternary peritecto-eutectic points as follows:
:L (1365K, 71.mol%Ni-6.mol%Mo-.mol%)=(Ni)++
:L (1355K, 62.mol%Ni-2.mol%Mo-30.mol%)=++
:L (1445K, 42.mol%Ni-30.6mol%Mo-10.mol%)=(Ni)+NiMo+
P₁:L (1812K, 34.mol%Ni-42.mol%Mo-.8mol%)+MoB=+
P₂:L (1633K, 42.mol%Ni-40.4mol%Mo-17.mol%)+Mo=+
:L (1812K, 53.mol%Ni-33.mol%Mo-12.8mol%)+Mo=NiMo+
:L (1622K, 51.mol%Ni-31.6mol%W-17.4mol%)=(Ni)+W+
:L (1260K, 71.mol%Ni-.mol%W-.mol%)=(Ni)++
:L (1291K, 65.4mol%Ni-4.8mol%W-29.8mol%)=++
P₁:L (2115K, 23.8mol%Ni-43.1mol%W-33.1mol%)+WB=+
P₂:L (1657K, 48.mol%Ni-33.1mol%W-18.mol%)+=W+
The calculated phase diagrams are expected to be useful for the development of new Ni-based heat-, corrosion- or wear-resistance alloys.

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Activity-directed isolation of the ethyl acetate, methylene chloride and n-hexane fractions of Gloiopeltis furcata resulted in the isolation of 18 compounds. Their structures were elucidated as 2-(-hydroxy--oxotetrahydrofuran--yl)acetic acid (1), glutaric acid (2), succinic acid (), nicotinic acid (4), ()-4-hydroxyhex-2-enoic acid (), cholesterol (6), -hydroxycholesterol (), uridine (8), glycerol (), -(hydroxymethyl)-2-methoxybenzene-1,-diol (10), (,)--oxodeca-,-dienoic acid (11), (Z)--ethylidene-4-methylpyrrolidine-2,-dione (12), dehydrovomifoliol (13), loliolide (14), cholesteryl stearate (15), palmitic acid (16), cis-,8,11,14,17-eicosapentaenoic acid (17) and α-linolenic acid (18) on the basis of spectroscopic and chemical evidences. Their anticholinesterase and antioxidant activities were evaluated via inhibitory activities on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) as well as scavenging activities on 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical and peroxynitrite (ONOO⁻). All isolated compounds (1—18) exhibited moderate AChE inhibitory activities with IC₅₀ values ranging from 1.14—12.50 μg/ml, whereas 1, , , 17, and 18 showed mild BChE inhibitory activities with IC₅₀ values ranging from .57—15.89 μg/ml. Although most of the compounds isolated were lacking the scavenging activity on DPPH radical and ONOO⁻, and 10 showed good DPPH radical scavenging activity, and , 10, and 16 showed potent ONOO⁻ scavenging activity.

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The title compound, methyl 2-cyano-,11-dioxo-urs-1,12-dien-24-oate (C₃₂H₄₃N₁O₄), crystallizes in the orthorhombic space group P2₁2₁2₁ with the following unit-cell parameters: a = .8862(2), = 17.6554(), c = 20.0326()Å, Z = 4. The crystal structure was solved by direct methods, and refined by full-matrix least-squares procedures to a final R-value of .0365 for 4164 observed reflections. The dihedral angle between the ester moiety and ring A is .(1)°. Rings , and exist in chair conformations, while rings A and C adopt sofa conformations. The ring junctions A/ and /C are trans fused, while ring junctions C/ and / are quasi-trans and cis, respectively. The methyl carbons located at various positions are significantly deviated above and below the plane of the molecule. The crystal structure is stabilized by intra and intermolecular C-H…O hydrogen bonds.

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It has been shown after mathematical and mechanical investigation that Limit Equilibrium Method (LEM) can be considered as a method to obtain the necessary condition of Slip Line Method (SLM), and that the solution can be obtained under the condition that F_s=1 and ∂F_s/∂θ=O, where F_s is the safety factor and θ is the inclination of the plane on which the safety factor is defined. Next, the generalized LEM (GLEM) is proposed, dealing with the following points : (1) Triangular or quadrangular blocks can be treated; (2) Safety factors are defined also on interblock planes; and () All types of plastic problems, slope stability, bearing capacity, and earth pressure are identically formulated. Two situations regarding treatment of the moment equilibrium condition are discussed. GLEM is applied to well-known problems. The results agree well with those obtained by theoretical methods. GLEM can be used to obtain the distribution of earth pressure or bearing capacity. GLEM, Iike ordinary LEM, is very effective for the practical problems, but GLEM is more theoretical and it can result in more accurate solutions.

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[1] The purpose of this reserch is to make clear what type of design can give good effects to win the high readership score. At the begining I had to know what factors decide the readership score, and how to change the quality of the desing into numerical value. I have used the method of multi-dimentional analysis with the help of a computer, and got the estimation formula, with kinds of factors, as follows ; A^^〜=+C++K+aE+bF+cG. A^^〜=estimated values of the readership score. 1) , C, , K : these four factors are given as category values (so we call them); each factor is classified into several categories. =week day, classified into categories. C=pages of a newspaper, which are characterized by the kinds of articles, news, and the other reading matters, classified into categories. =kinds of goods and trades of the advertizement, classified into 14 catedories. K=constants, given to each 13 surveys. 2) , F, G : these factors are given as numerical values. G=area of advertizement, measured by the unit of column in the whole page length, being classified into 6 kinds of area (2., ., , , 10, 15) and 15 column means a whole page, about 2,000cm^2. , F are the marks obtained in the design of advertizements. =sum of the marks obtained in each design element on the advertizement. F=the marks obtained on the whole effect of the design. ) a, , c : coefficients Using the above formula with the category values and the coefficients, we can obtain the naked design effect from the actual value A of readership score: aE+bF=A-(+C++K+cG). In this research, I used 1,829 data of readership score from 1960 to 1968, being obtained by 13 survevs, spring and autumn twice a year. The sample of size each survey was ,541, 2,251, or 200 in the other 11 surveys. Multiple correlation coefficient between the estimated value A^^〜 and the actual value A is .951. The table 2^* shows the contribution indexes of each factor by kinds of expression-(1) Range : the absolute difference between the maximum and the minimum category values, (2) Standard deviations of the category values, () Partial correlation coefficient : the relationship between the actual values A and each factors. *see the table 2 in the thesis in Japanese. [2] The important point was in the determination of the values of , F. is the sum of the marks obtained in each design element, classified into four kinds : =_1+_2+_+_4. design elements [table] _1, _2, _, _4, these values have the grades, as , 1, 2, , 4 and is given to the design that has no attractive effect or no applicable element. And obtain the marks of to grades as the sum of them. The values of F have also grades, to 4. The principles to determine the values of , F are as follows : a) The marks obtained of , F must be the relative values among the each survey, and at the same time, they must have constancy within the same survey-the same elements of design must win the same marks obtained. ) They must be determined as to win the highest multiple correlation coefficient, when they are put into the estimation formula. c) They must be reasonable. In order to justify them, we must carry many researches on the actual condition. The frequency of accurence of each grade of , F values, as the table -4, and - in the thesis in Japanese.

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当院乳腺外科に受診される主訴では，自己触知，市町村などでのMMG 検診，開業医などでの施設定期検診発見異常のつが主である。クーポンによる行政検診が始まっている現在でも，当院では５７．１％を超える症例が自己発見である。そもそも乳腺の解学的観点より各領域の腫瘍発生分布が存在することは知られている。発見方法によらず，自然発生分布と発見分布は一致するはずである。症状が認められるまで医療の関与がない自己触知で発見された腫瘍の分布は，最も自然発生分布を反映しうるのではないか。それと比較して，施設検診，MMG（のみによる）検診では，乳腺の各区域の腫瘍発見分布に解離がないか，後ろ向きに検討した。２０１０年から２０２１年まで，先述のつの主訴で当院を受診された３００５症例を対象とした。自己触知で発見された症例の内，主たる異常の存在部位をABCDE 区域に分類した。それぞれn（％）で表し，A：３９２（２５．％），：１５４（．％），C：６８９（４４．％），：１５３（．％），：１６０（１０．％）であった。施設検診ではそれぞれA：（２３．１％），：３５（．％），C：１５１（４１．％），：４７（１３．１％），：４４（１２．２％）と，p＝．３０５３となり有意差はなかった。MMG 検診ではA：２１４（２６．％），：６３（．８％），C：３６６（４５．６％），：１０２（１２．％），：５８（．２％）と，p＝．０１４４と有意差を示した。特に 区域の発見に弱さを示している可能性が示唆され，他発見方法とMMG 検診での発見分布に解離が見られた。逆にMMG 検診では発見時Stage では施設検診よりもむしろ優れており（p＜．０００１），感度の問題ではなく，乳腺濃度分布によって 区域の腫瘤に対し感度が低い可能性が考えられた。

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For three monthes since July 1957, the authors have investigated as to peripheral blood picture of healthy adults, (man 55, woman 54) in Toshima village, Tokyo-To and obtained the following results (Figures indicate average values)
1) Number of Erythrocytes were in 424.8×10⁴ in male and 411.×10⁴ in female and average figure was 418×10⁴ in total.
2) Number of Leucocytes were about 5235 in male, about 5306 in female and total average 5270. These figures were lower than the standard figure of Japanese.
) Haemoglobin content (by Sahli-Haemochromometer) were .% in male and 21.% in female and .6% in total.
4) The results of differeutial count of Leucocyte were as follows.
a) Neutrophil Leucocytes, male 46.% female 52.1% in total 49.2%.
) Lymphocytes, male 47.% female 42% in total 45.%
c) As to monocytes, male 2.% female 2.% in total 2.8%
) As to eosinophil leucocytes, male 2.% female 1.% in total 2.%
) As to basophil leucocytes, male .03% female .14% in total .09%
The authors should pay attention to the lower figure on erythrocytes, leucocytes, and haemogloblin, but they can not tell, without consideration of difference of the life conditions of natives, that these lower figures are significant, therefore they must study further several factors on this matter. As drinking water is rainwater, they have to consider the influence by radioactive materials in future, but at present status they believe it is not necessary to take into consideration the influence of radioactive material from the resultabove mentioned.

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