-(2-Aminophenylthio)-, 6-dichloropyridazine (I) on treating with dil. Hydrochloric acid or acetic acid gave -chloro-H-benzo[]pyridazino[, -][, ]thiazine (, -diazapheno-thiazine type) through rearrangement and cyclization. -Chloro-10H-benzo[]pyridazino-[, -][, ]thiazine (, 2-diazaphenothiazine type) was obtained by either heating of I at 150°or treating of I with conc. hydrochloric acid through direct cyclization. The mechanism of the aforesaid reactions was discussed using a molecular orbital method. Several , 2-and , -diazaphenothiazine derivatives were synthesized.

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The performance of single pitch and multi pitch screw anchors during the application of installation torque is presented. An experimental testing program was conducted using five models of screw anchors with different geometry. The effect of the shape of the screw element, sand properties, and installation depth on the required installation torque value was examined. A theoretical model was developed from which the required installation torque value can be calculated in terms of the influencing factors. The required installation torque can be determined in terms of the ultimate uplift resistance calculated from any of the available theories. Based on the actual installation torque value measured in the field, the anticipated pullout capacity can be back calculated from the present theory. A comparison between theoretical and experimental results showed good agreement. Also, good agreement was observed when the present theoretical results were compared with the available field results reported in the literature.

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L'entree en Iran des armees britannique et sovietique s'est produite en aout 1941. Elle ebranla du coup le regime de la dynastie pahlavi qui etait au pouvoir depuis 16 ans, et mena le pays vers l'instabilite politique et le chaos social. La defaite de l'arme gouvernementale, qui etait le pivot du regime de Reza Shah, reduisit considerablement le controle du gouvernement central dans le pays. Cette situation politico-sociale confuse permit le developpement de differents mouvements politiques en Iran. C'est ainsi que le 16 aout 1942 le parti clandestin Komeley Jiyanewey Kurdistan (J-K) est ne a Mehabad, une ville au nord-ouest de l' Iran. Des sa formation, ce parti a su etendre sa sphere d'activite et, en une courte periode de temps, a fini par mettre sous son influence la ville et ses alentours. A la fin de la Seconde Guerre mondiale, en ete 1945, le J-K etait devenu une organisation representant le mouvement nationaliste kurde en Iran. C'est a ce moment-la qu'un autre parti politique, le Hizbi Dimokratiki Kurdistan (HDK), fonde par Qazi Mihemed a Mehabad aussi, devait remplacer le J-K. Des le janvier 1946, le HDK proclama l'instauration de la≪Republique de Kurdistan≫. Cependant, les troupes sovietiques qui avaient pris sous leur protection la Republique evacuerent les terres iraniennes, en mai 1946. Six mois plus tard, sous la pression militaire du gouvernement central iranien, la republique s'ecroula. Deux theories tentent d'expliquer le passage du J-K au HDK. William Eagleton Jr., par exemple, affirme dans The Kurdish Republic of 1946 que le HDK a ete cree sur le conseil des autorites sovietiques. L'ex-secretaire general du Parti Democratique du Kurdistan d'Iran, 'Ebd el-Rehman Qasimlu maintient par contre que Qazi Mihemed a etabli le nouveau parti de sa propre initiative, eu regard a la situation politique de cette epoque-la. Il considere que la passage du J-K au HDK comme etant l'evolution d'un parti nationaliste clandestin en un parti democratique. En analysant ces deux theories et en se basant sur les autobiographies des personages qui se sont engages dans cet evenement, cette etude tentera d'examiner le principe directeur et les activites du J-K et de mieux comprendre les raisons pour lesquelles le J-K devait etre remplace par le HDK. La conclusion generale portera sur les differents objectifs politiques du J-K et du HDK. Le J-K visait l'elevation du niveau culturel du peuple tout en luttant contre le tribalisme, qui etait, selon lui, le probleme majeur de≪la nation kurde≫, et cela en ecartant toute idee de revolte militaire. Le J-K a aussi exclu de son cadre les elites sociales telles que les leaders des tribus et dirigeants religieux de peur qu'ils n'excercent une influence sur les membres du parti. L'automne de 1944 fut le debut d'une nouvelle ere pour le mouvement kurde. Alors que l'espoir de l'autodetermination augmentait parmi le peuple a mesure que s'approchait la fin de la guerre, la necessite de la force militaire a commence a se faire sentir dans le J-K. C'est pour cela que s'est produite au sein du parti une tendance a compter sur l'aide militaire des sovietiques et a recourir au leadership de Qazi Mihemed, qui avait une certaine influence meme sur les leaders tribaux. Mais cette tendance etait essentiellement incompatible avec la ligne fondamentale du J-K et, graduellement, a prive ce parti de sa raison d'etre. Ainsi, le HDK se substitua au J-K en tant que≪parti democratique≫visant a rallier d'abord les elites sociales sous sa banniere, en s'appuyant sur l'autorite personnelle de Qazi Mihemed.

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BCR-ABL

International Scale（IS）測定はチロシンキナーゼ阻害剤で治療されている慢性骨髄性白血病（CML）患者の治療効果をモニターする上で重要な検査法である。稀ではあるが，BCR-ABL IS測定ができないCMLが存在することが知られている。本研究において，我々は，そのようなBCR-ABL IS測定のできないCML患者を経験し，分子生物学的な方法で，その原因を解明した。本例ではABL遺伝子における切断点がa2エクソン内にあることが分かり，そのことがABLのa2エクソンを欠いた14a（a）キメラ遺伝子のmRNAのみの発現を誘導していた。a2エクソンは本邦における検査部でのIS測定において重要な要素であり，これが欠損することが測定不能の原因であった。このようなIS測定ができない稀なCML症例をさらに集積して，その分子構造を解明することが待たれる。

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The possibility of attenuation of microseismic waves due to the presence of an upward folding of the ocean bottom into the liquid is discussed in this paper. The upward folding of the ocean bottom has been idealized by means of an irregularity in the form of a rectangle intruding into the liquid and the evaluation of the displacement component at any point of the solid medium has been carried out in two stages. First, the change in the incident mode of the surface wave due to the presence of the rectangular irregularity has been determined, and second, the subsequent change of the resulting displacement components due to the termination of the liquid layer and the step change in elevation of the solid medium at the continental margin has been discovered. Finally, numerical calculation has been made to determine the attenuation of the microseismic waves of different periods due to the presence of the rectangular irregularity at the ocean bottom.

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The association between apolipoprotein (Apo-) polymorphism and the response of plasma cholesterol to dietary therapy (cholesterol intake of less than 300mg/day) was investigated for about 8 weeks in 208 nonfamilial hypercholesterolemia patients (/ 161, / 47). The baseline lipoprotein concentration and the intake of energy and lipids were not significantly different between subjects with / and those with / phenotypes. After the dietary therapy plasma total cholesterol and low density lipoprotein cholesterol were significantly decreased in both phenotype groups (p<0.05). The patients with / had significantly smaller reductions of LDL-C than the patients with /. The changes of LDL-C showed a significant difference between the patients with / and / by the Kruskal Wallis test (p=0.041). The presence of / predicted the degree of cholesterol reduction following dietary therapy.

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-Chloro--mercapto--ethoxypyridazine () was heated under reflux in abs. ethanol for three hours to form concurrently four products with novel rings in the dipyridazo-, -dithiin system, , -diethoxydipyridazo [, - : ', '-]-, -dithiin (pale yellow needles, mp 211°, 13% in yield) (Ia), , 6-diethoxydipyridazo [, - : ', '-]-, -dithiin (colorless needles, mp 260°, 12% in yield) (IIa), dipyridazo [, - : ', '-]-, -dithiin-, (H, 6H)-dione (colorless solid, mp>300°, 24% in yield) (Ib), and dipyridazo [, - : ', '-]-, -dithiin-, 6 (H, H)-dione (colorless solid, mp>300°, 16% in yield) (IIb). Structural assignment of the compounds, Ia, IIa, Ib and IIb, was confirmed by their physico-chemical constants and chemical experimental evidences. Similar concurrent formations of an isomeric pair of , -disubstituted dipyridazo-[, - : ', '-]-, -dithiins (I series isomers) and , 6-disubstituted dipyridazo [, - : ', '-]-, -dithiins (II series ones) were also observed in those cases in which heating , -dichloro--mercaptopyridazine (), -chloro--mercapto--benzylthiopyridazine () and -chloro--mercapto--morpholinopyridazine () in similar reaction conditions (heating in proper polar solvents for proportionatd periods) formed a pair of the , -dichloro- (colorless needles, mp 275°, only trace in yield) (Ic) and , 6-dichloro derivative (pale yellow needles, mp 307°(decomp.), only trace in yield) (IIc), , -dibenzylthio- (yellow crystals, mp 230°, 29% in yield) (Id) and , 6-dibenzyl derivative (red crystals, mp 252°, 23% in yield) (IId), and , -dimorpholino- (colorless crystals, mp 268°, 38% in yield) (Ie) and , 6-dimorpholino derivative (colorless needles, mp 291°, 25% in yield) (IIe), respectively. A rather complex cyclization furnishing the concurrent formation of two pairs of the dipyridazo-, -dithiin derivatives was found in the reaction of heating -chloro-, -dimercaptopyridazine (6) in a similar reaction condition, followed by benzylation, in which a pair of the derivatives with another novel ring, dipyridazo [, - : ', '-]-, -dithiin, the , -dibenzylthio- (colorless plates, mp 168°, % in yield) (VI) and , 6-di-benzylthio derivative (yellow needles, mp 210°, 11% in yield) (VII) and another pair of derivatives with a known ring, dipyridazo [, - : ', '-]-, -dithiin, the , 6-dibenzylthio-(yellow needles, mp 178°, 19% in yield) (IV) and the , -dibenzylthio derivative (colorless needles, mp 170°, % in yield) (V) and none of Id and IId or , 6-dichlorodipyridazo-[, - : ', '-]-, -dithiin (If) and , -dichloro derivative (IIf) was detected. NMR spectra of some dibenzylthiodipyridazo-, -dithiin derivatives were compared. A discussion of the cyclization mechanism involved in these reactions is also proposed.

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Transcription of human adenovirus genes is regulated by a variety of cellular and viral transcription factors. We described in this issue recent informations of adenovirus A proteins, and cellular factors, TF II D, ATF/TF, 2F, TF and USF, responsible for transcription of adenovirus genes. In addition to the transcription factors, we introduced a newly concept of initiator, which is a transcription control element of adenovirus major late promoter.

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. The chromosome numbers of 64 species have been studied on which 56 are investigated for the first time.
2. Morphological, anatomical and cytological findings on the Musaceae in the broad sense are considered from a phylogenetical standpoint and three distinct groups:
a) Musa-Ensete, ) Ravenala-Strelitzia-Phenakospermum and c) Holiconia are recognised as suggested by some authors. For these groups sub-familial status is proposed.
. Lowiaceae have been studied for the first time cytologically and their chromosome morphology, distinct from that of any other group of Zingiberales, confirms their claim to familial status.
. Consideration of the conflicting theories proposed to account for the higher chromosome number in genera like Globba, Alpinia, and Phaemeria, etc. leads to rejection of Chakravorti's hypothesis of wholesale fragmentation of chromosomes and the acceptance of the opposed view of Raghavan and Venkatasubban and others.
. Holttum's transference of the genus Zingiber to the tribe Hedychieae has been given cytological support on the following points:
a) the basic number in the genus Zingiber correlates with that of Kaempferia.
) the new tribe Alpinieae (which is infact Zingibereae without Zingiber) have consistently 48 chromosomes in their somatic complements.
6. It is suggested that the African representatives of Kaempferia should be given the status of genus; Cienkowskya on the following points:
a) the difference in floral morphology
) geographical separateness and
c) the difference in the number and morphology of the chromosomes. By comparing the present and past findings, various lines of evolution of the chromosome complements within each group are discussed.
7. The basic number 11 is considered to be probably the original one for the Zingiberales as a whole, being present in Ravenala which is the most primitive member in the order. From this secondary basic numbers have arisen through evolution.

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The leaning tower of Pisa is a famous historical structure, especially in the field of soil mechanics. In this paper, the historical development of the inclination is reconstructed considering that a ground failure took place after each of the three construction phases. Model tests (scale : 130) were carried out in order to predict that the tower will fail definitely, i.. without any further disturbances, at an angle of inclination of .7°, which is dramatically close to the actual value of .°. The estimated probability of failure rises very quickly with an increase in the angle of inclination. Conservation of the tower should be done therefore with utmost caution.

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Limiting equilibrium state of saturated soils is solved taking into account drainage conditions during loading stage before reaching limit state. In analysis procedure, non-dilatant characteristics are assumed at limit state and then the failure problem discussed in the present study is concerned with normally consolidated and/or lightly overconsolidated soils. When solving statically indeterminate limiting equilibrium state one needs constitutive relations at limit state. In saturated soils, however, since the constitutive relations are generally expressed in terms of effective stresses, an additional field equation is required in order to link a velocity field to a pore pressure field. Therefore the problem should be solved as a coupling problem between these two fields. Two distinct types are discussed, one is undrained problem and the other, fully drained problem. Topics covered in the present study are as follows : () Undrained bearing capacity and excavation stability of soft clays, (2) Bearing capacity under partly drained and/or partly swelling condition, () Comparison between rapid loading condition and undrained condition, and () Seepage failure of loose sandy soils under fully drained condition.

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演題のアズレン骨格を有する拡張パイ電子系芳香族炭化水素6を合成したところ，6が極めて強力な2電子供与体として働くことを認めた．また，6に強酸（例えば，HPF₆）を加えるだけで，定量的に対応するジカルボカチオン化合物7が得られることは注目に値する．さらに，6が強力な電子供与体であることから，様々な有機材料への応用も期待できる．本討論会では，今回初めて単結晶化に成功した7の結晶構造と演題のパイ電子系化合物6の分子特性について詳述したい．

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