A sample of [

3H

] tobrarnycin (5, 000 Ci/Mole) has been synthetized and incubated with
the bacterial ribosome and its subunits. The results obtained show that this antibiotic has
two types of binding sites. The primary one is probably responsible for the inhibition of
protein synthesis whereas the secondary one is probably related to the misreading and reading
tiirough of the messenger RNA.

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The Gujarat earthquake in India occurred in January, 2001, and caused significant damage in the province of Gujarat. The Japanese Geotechnical Society sent a small reconnaissance team to the damaged region after the quake. The present text presents the report from this activity. The major attention of the team was focused on geotechnical aspects of the damage which were related to earthfill dams and harbor land fills. It was found that a significant portion of damage was concentrated in fills resting on soft natural soils. Swedish weight soundings which were conducted at two places demonstrated the existence of such a soft subsoil. From this, it was concluded that amplification of earthquake shaking as well as the permanent deformation in the soft foundation soil induced such kinds of damage as subsidence, cracking, and lateral spreading in overlying artificial fills. For the better seismic resistance of those affected fills during future earthquakes, the improvement of soft subsoil seems essential.

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The boundary element method expanded in frequency domains is presented to analyze the dynamic interaction between an embedded flexible rectangular foundation and soil with consideration of the obliquely incident waves. Numerical results describing the influence of the flexibility of the foundation on the dynamic responses of the foundation due to obliquely incident waves indicate that the flexibility of actual foundations can diminish the reduction of translation responses and increase the rotational responses in the high frequency range. These phenomena are more conspicuous as the embedment ratio is larger and the value of the wave velocity ratio of the soil and the foundation approaches to unity. When the high frequency components of the input ground motion are important and the basement has higher flexibility (for example ₂v_s/₁v_s >0.), the analysis method which considers the basement as a rigid foundation may lead to unsafety estimations and the estimation of the flexibility of the foundation is necessary as analysing the effective input motion with consideration of the incident waves.

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The results of an investigation of soil liquefaction caused by the 1995 Hyogoken-Nambu earthquake are described. Massive and extensive soil liquefaction occurred in the coastal areas of reclaimed land, in old river beds, in Holocene deposits and in areas reclaimed from old ponds. A man-made island of weathered granite, or “Masado, ” was also seriously damaged by soil liquefaction. The maximum distance from the epicenter to the liquefied sites was approximately 90 km. Several characteristics of liquefaction formation, strong earthquake motions recorded on Port Island, and damage to structures from this earthquake are discussed.

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光磁気ディスクの高密度化を促進させるために, T符号と名付けた値記録符号を開発し, いずれのPRML信号処理と組合せれば従来方式よりもビット誤り率の改善をはかることができるのかを検討している.検討対象としているT符号のパラメータはd=1,k=,c=2の各制約を有している.ビット誤り率特性を従来の代表的な2値符号である9符号と10符号, ならびにやはり代表的な値符号でT符号と同じ符号化効率を持つT符号と比較検討行なった, その結果, BER=10^<->においてT符号にPR(1,2,1)方式を組み合わせることで従来のいずれの記録符号とPRMLとの組合せよりも所要CN比を改善できることができた.

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　Conçue comme une négativité infinie et absolue, l’ironie déclenche une déstructuration sémantique et diégétique. Dans En attendant Godot de Beckett， la fonction de chaque discours et de chaque action est systématiquement réduite à une méta-action négative, par quoi on peut définir la notion d’attente. Cette perturbation qui détraque les discours et les actions opère à tous les niveaux de la pièce．C’est la méthode de（dé）construction fondamentale chez Beckett，qui consiste à injecter en permanence de l’ironie pour subvertir l’ordre des choses． La même démarche ironique avait été adoptée par les préromantiques pour surmonter une difficulté soulevée par la philosophie idéaliste，à savoir la division entre les phénomènes et les choses en soi．Marqué par l’influence profonde de la pensée de Schopenhauer，Beckett se place dans le sillage idéaliste des préromantiques，et leur emprunte leur méthode d’évocation de l’inexprimable par le recours à l’ironie．

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Two new partially saturated tricyclic ring systems, , a, 7, , 9, 10, 10a, 11-octahydro-11-oxodibenz [, ] oxepins (a and ), and -thiepins (a and ) were synthesized. Compounds a and were desulfurized to give a pair of isomeric 2-methylbenzoylcyclohexanes (10a and 10). Deuterated a and (11a and 11) were prepared starting from butadiene- (12). The stereochemical features of a (trans), (cis), a (trans) and (cis) are compared with those of 10a, 10, 11a and 11 on the basis of proton nuclear magnetic resonance data.

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This study was performed to clarify which factors affected damage to tame-ike (small embankment dams for irrigation) in Hokudan Town as a result of the January 17, 1995 Hyogoken-Nambu earthquake. Factors were assumed to be : Location (.g., Distance to Epicenter, etc.), Structure (.g., Angle to Nearest Fault, Embankment Volume, etc.), Soil Properties of Embankment, Geology of Dam Site and History (Era of Construction, Repaired, etc.). Multivariate statistical analyses were performed for documentary data (damaged : 181, undamaged : 328). Ordinary statistical analyses were conducted for the data investigated in situ for soil properties of the embankment. The results show that the factors causing damage to dam are : (1) Nearest Fault (Nojima, Mizukoshi and D2), (2) Distance to Nearest Fault (less than 500 m), () Distance to Epicenter (approximately to 14 km, which almost agrees with the location of seismic intensity 7 JMA), () Elevation of Dam Site (higher than 100 m), (5) Embankment Volume (the greater the volume the more damage was caused), () Direction of Dam Axis (normal or diagonal to the epicenter or to nearest the fault), (7) Plan View of Dam Axis ( or axes), () Surface Geology of Dam Site (non-cohesive soil type ground), (9) Era of Construction (prior to 1891) and (10) Soil Properties of Embankment (sand, not silty sand or gravel, penetration resistance that is 10% smaller than the undamaged dams).

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　今、医療の現場は安心・安全で良質なサービスの提供を目指している。患者の声に耳を傾け、更に満足がいく医療を提供する為に取り組んでいる。　
　安心・安全の提供は、医療者側だけの取り組みでは困難な場面もある。一例として療養上の世話の中で挙げられるのが、転倒・転落である。当院において、平成16年度のヒヤリハット・事故報告書においても91件と多い。この転倒・転落を予防する対策としてアセスメントシートがあり、安全を守るために離床センサーの使用・身体拘束をせざる負えない状況がある。この身体拘束に関しては、転倒・転落予防の他に必要な処置を遂行する為であったり自傷行為の予防などの目的がある。患者の安全を守る為に行う行為ではあるが、拘束するという行為への看護師のジレンマも存在すると考える。どのような状況・時期において“倫理”を感じ、ジレンマとして生じるのか。そのような状況の場において、どのように対処しているのであろうか。急性期医療の場においては、ある程度の期間が過ぎれば患者の状況も安定され日々の“拘束の必要性”もなくなる。しかし、一般病棟における患者の状況はまた異なってくる。一般病棟においては、急性期の患者・慢性期の患者・終末期の患者が混在する。終末期の患者の不穏・せん妄の状況に対して、勿論患者の安全を守るためではあるが“拘束”をせざるをえない状況がある。本当に拘束することが正しいことなのか疑問に感じることが多々ある。これは、看護師と医師とではまた安全と倫理という面では捉え方の差があるのではないかと考える。医師も患者の安全といのちを守るために身体拘束は必要であると考えるが、看護師は実際に拘束をする立場であり患者の“声”を聴いている立場にあり患者の人間としての尊厳という点では医師よりも考え悩む比重が大きいと感じる。患者の実際の“声”はいろいろであるが、拘束をせずとも傍にいることで患者の不穏・せん妄状態が落ち着くことはある。しかし、一人の患者にどれだけの時間を費やしていけるのか、急性期医療を必要としている患者が存在する病棟の中で、終末期の患者の精神的看護はあとまわしになる。傍にいたくてもいれない状況の中で、不穏患者に対してやむをえず拘束をせざるをえない状況があるのが現状である。拘束の方法も、患者のその時の状況を看護師が判断し寝衣のみの拘束であったり手袋（ミトン）をせざるをえない状況もある。　　
　急性期医療と終末期医療が混在する病棟の中で、身体拘束をどう捉えていくか患者の人間としての尊厳を守り安全を守るということはどういうことなのかということを、常にチームの中で検討していき患者個々に合わせた細やかな配慮をしていく必要がある。

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Stereoselective synthesis of the , 5-syn, 5, -anti adducts (14 and 16) on the aldol condensation of the Z (O)-lithium enolate, derived from the -enone (2), to α-alkoxy aldehydes (12 and 13) was proved via the successive intramolecular Diels-Alder reaction.

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The possibility of attenuation of microseismic waves due to the presence of an upward folding of the ocean bottom into the liquid is discussed in this paper. The upward folding of the ocean bottom has been idealized by means of an irregularity in the form of a rectangle intruding into the liquid and the evaluation of the displacement component at any point of the solid medium has been carried out in two stages. First, the change in the incident mode of the surface wave due to the presence of the rectangular irregularity has been determined, and second, the subsequent change of the resulting displacement components due to the termination of the liquid layer and the step change in elevation of the solid medium at the continental margin has been discovered. Finally, numerical calculation has been made to determine the attenuation of the microseismic waves of different periods due to the presence of the rectangular irregularity at the ocean bottom.

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クラスター状態に対してreaction matrix methodを適用するに際して,核子間散乱相関とクラスター間の相対運動とをself-consistentに取り扱う方法が提案される。基本的な考え方は,generator coordinate method(GCM)で解かれた状態を非摂動状態とするreaction matrix equationを解くことである。GCM方程式の固有値をstarting energyとして含み,かつgenerator coordinateによって張られる模型空間を排除するrejecting-operatorを有するreaction matrix eauationが与えられる。両者はiterationの方法でself-consistentに解かれる。以上の方法はクラスター間の距離パラメーターに応じて有効相互作用が変化するという考え方から,GCM方程式の解として現われる状態に応じて有効相互作用が変化するという考え方への転換をもたらす。

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11-Amino-, a, 7, , 9, 10, 10a, 11-octahydrodibebenzo[, ]thiepines (a-d) and -oxepines (7a-d) were synthesized by the Leuckart reaction of , a, 7, , 9, 10, 10a, 11-octahydro-11-oxodibenzo[, ]thiepines (1a, )and -oxepines (2a, ) followed by hydrolysis of the reaction products a-d and 5a-d, respectively. The four diastereomers, cis(a-H, 10a-H)-cis(10a-H, 11-H) a and 7a, cis(a-H, 10a-H)-trans(10a-H, 11-H) and 7, trans(a-H, 10a-H)-trans(10a-H, 11a-H)c and 7c, and trans(a-H, 10a-H)-cis(10a-H, 11-H) d and 7d, were isolated and their configurations and conformations were elucidated by chemical methods together with ¹H-nuclear magnetic resonance spectroscopic and X-ray crystallographic analyses.

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The objective of this article is to propose and evaluate a sliding-block model to deal with very large displacements of slopes when a horizontal earthquake is applied. The slip surface consists of two inclinations on which full shear resistance is mobilized. Internal shearing exists along a sub-plane that intersects the angle between the two sub-planes that form the external slip surface. The ratio of the distance moved along the two external sub-planes depends on the inclination of the internal sub-plane. If there is a water table line, undrained conditions are assumed during motion and total stress analysis is performed. The governing equations of motion are formulated, analytical solutions are obtained for some cases, and back-analysis of four well-documented slides is performed.

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