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  • George W. Lee
    燃料協会誌
    1973年 52 巻 3 号 171-177
    発行日: 1973/03/20
    公開日: 2010/06/28
    ジャーナル フリー
  • Grover Loening
    日本航空学会誌
    1963年 11 巻 119 号 373-380
    発行日: 1963年
    公開日: 2009/05/25
    ジャーナル フリー
  • 小田切 孝人, 田代 眞人
    ウイルス
    2013年 63 巻 2 号 233-240
    発行日: 2013/12/25
    公開日: 2014/10/31
    ジャーナル フリー
  • I.
    F
    . Davies
    Journal of Light & Visual Environment
    1984年 8 巻 1 号 1_9-1_20
    発行日: 1984年
    公開日: 2011/05/20
    ジャーナル フリー
  • 琴尾 幸徳, 石川 成実, 田辺 順子, 御園 生尭久
    日本化学会誌(化学と工業化学)
    1980年 1980 巻 9 号 1391-1396
    発行日: 1980/09/10
    公開日: 2011/05/30
    ジャーナル フリー
    Nアルキル
    3
    ,
    4
    :
    9
    ,10-ペリレンテトラカルボン酸モノアンヒドリド=モノイミド[
    4
    a~
    e
    ]と芳香族アミン(アニリン,p-トルイジン,p-アニシジン,
    3
    ,
    5
    -キシリジン,
    4
    -アミノナゾベンゼン,およびo-フェニレンジアミン)を縮合して非対称型
    3
    ,
    4
    :
    9
    ,10-ペリレンビス(ジカルボキシミド)誘導体-N-アルキル-N'-アリール-
    3
    ,
    4
    :
    9
    ,10-ペリレンビス(ジカルボキシミド)(〔
    5
    a~
    e
    〕,〔6a~
    e
    〕,〔7a~
    e
    〕,〔
    8
    a~
    e
    〕,〔
    9
    a~
    e
    〕,および〔10a~
    b
    〕)を合成した. これらの各誘導体はすべて赤色系の色相を示し, 顔料試験の結果N-ブチル-N'-アリール-
    3
    ,
    4
    :
    9
    ,10-ペリレンビス(ジカルボキシミド)(たとえば〔
    5
    e
    〕や〔6
    e
    〕)がとくにすぐれた耐光性を示した.
  • Charles-Henri de NOVION, Paul COSTA
    Journal of Nuclear Science and Technology
    1971年 8 巻 10 号 600-601
    発行日: 1971/10/25
    公開日: 2008/12/19
    ジャーナル フリー
  • 橋口 英俊
    日本医科大学雑誌
    1983年 50 巻 4 号 563-585
    発行日: 1983/08/15
    公開日: 2009/12/04
    ジャーナル フリー
    Thirty-six patients (19 males, 17 females: atypical schizophrenia;
    3
    , typical schizophrenia;
    9
    , depression; 11, neurosis and other psychiatric disorders;
    8
    ) were operated on according to orbitoventromedial undercutting by Hirose. In all cases, the Rorschach test was carried out and daily behaviors were studied. Thirty-one scales of the test were subjected to multivariate analysis whereas the behaviors were evaluated according to the following criteria, i.
    e
    ., A: recovered or symptom free,
    B
    : markedly improved,
    C
    : moderately improved, D: slightly improved and
    E
    : not improved. The following results were obtained.
    1) The evaluation of behaviors is as follows. A: 12 cases,
    B
    :
    9
    ,
    C
    :
    9
    , D: 6,
    E
    : none.
    2) It was found that scores of
    F
    +106% and R+106% scales were significantly higher after the operation than before; that correlation coefficients between the scores before and after the operation were considerably high.
    3
    ) Factor analysis followed by varimax rotation was carried out. Six factors were extracted, i.
    e
    ., (
    F
    1) sensitivity to emotional stimuli, (
    F
    2) ego-strength, (
    F
    3
    ) obsessional rigidity, (
    F
    4
    ) reaction time, (
    F
    5
    ) anxiety and tension and (
    F
    6) empathy. It was revealed that
    F
    2 was high in atypical schizophrenia, depression and neurosis, and that
    F
    2 and
    F
    6 were significantly different in terms of the factor scores among the four groups A,
    B
    ,
    C
    and D;
    F
    2 was highest in A, and lowest in D regardless of whether it was before or after the operation.
    F
    6 showed high scores in both A and
    C
    , and low in D.
    4
    ) Multiple discriminant analysis was applied to the data of the Rorschach test before the operation, by classifying 36 subjects into the four groups A,
    B
    ,
    C
    and D. As a result, high rates of correct diagnosis were obtained, i.
    e
    ., 100% for A, 78% for
    B
    , 56% for
    C
    and 100% for D. When the groups
    C
    and D were combined into one group (
    C
    +D) the highest percentage (100%) was seen in A, followed by
    B
    (89%) and
    C
    +D group (87%). When the groups A and
    B
    were combined into one group (A+
    B
    ), the percentages of correct diagnosis were
    81
    % for A+
    B
    , and 93% for
    C
    +D.
    In conclusion, it can be said that scales of the Rorschach test have been proved to be valid for predicting mental and physical states after the orbito-ventromedial undercutting.
  • Cbesseredes HORTS
    Journal of Human Ergology
    1982年 11 巻 Supplement 号 429-440
    発行日: 1982/12/15
    公開日: 2011/02/23
    ジャーナル フリー
  • Özkan ASLANTAŞ, Ebru Şebnem YILMAZ
    Journal of Veterinary Medical Science
    2017年 79 巻 6 号 1024-1030
    発行日: 2017年
    公開日: 2017/06/16
    [早期公開] 公開日: 2017/04/27
    ジャーナル フリー

    This study aimed to determine the prevalence of fecal carriage of extended spectrum β-lactamase (ESBL) and/or plasmidic AmpC β-lactamase (pAmpC) producing Escherichia coli among dogs (n=428) in Turkey. Polymerase chain reaction (PCR) and sequencing were used to characterize genes encoding β-lactamase and plasmid mediated quinolone resistance (PMQR). Antimicrobial susceptibility testing and PCRs for virulence genes and phylogenetic groups were also performed. Cefotaxime resistant

    E
    . coli isolates were detected in
    95
    (
    22
    .2%) of the swab samples. Sequencing analysis results showed occurrence of various β-lactamase genes: blaCTX-M-15 (62), blaTEM-
    1b
    (42), blaCMY-2 (
    22
    ), blaCTX-M-
    3
    (16), blaCTX-M-1 (15), blaOXA-1 (
    9
    ) and blaSHV-12 (
    3
    ) alone or in combination. The most frequently encountered phylogenetic group was group A1 (35.
    8
    %), followed by group D2 (
    22
    .1%),
    B
    1 (15.
    8
    %), D1 (
    9
    .
    5
    %), A0 (7.
    4
    %),
    B22
    (
    5
    .
    3
    %) and
    B23
    (
    4
    .2%), respectively. PMQR genes, aac(6’)-Ib-cr, qnrS1 and qnrB10 were detected in 25.
    3
    , 10.
    5
    and 1.1% of the isolates, respectively. While all isolates were susceptible to imipenem and amikacin, resistance rates to non-β-lactam antibiotics ranged from 20.0% for tobramycin to 56.
    8
    % for tetracycline. The virulence genes were only detected in 34 (36.2%) of the isolates and this isolates carried single or various combination of virulence genes of iucD, papC, papE,
    f17a
    -A and eaeA. Four isolates were identified as human virulent pandemic CTX-M-15 producing
    E
    . coli
    clone O25
    b
    :ST131/
    B
    2. To the best of our knowledge, this is the first study to show fecal carriage of ESBL/pAmpC type β-lactamase producing
    E
    . coli
    isolates among dogs in Turkey.

  • 小林 優, 家坂 貴子, 中野 江身子, 平山 耕一郎
    天然有機化合物討論会講演要旨集
    1989年 31 巻 71/P2-1
    発行日: 1989/09/17
    公開日: 2017/08/18
    会議録・要旨集 フリー
    Six new cembranoids sarcophytol P (
    3
    ), R (
    4
    ), S (
    5
    ), K (
    8
    ),
    F
    (11), and T (13) were isolated from the soft coral Sarcophyton glaucum. Sarcophytol P (
    3
    ) was shown to be the 20-hydroxy derivative of the major component sarcophytol A (1), and afforded the cyclization product 6 in CHCl_
    3
    at room temperature, in a same way as in 1. Sarcophytols R (
    4
    ) and S (
    5
    ) were correlated to 1, by conversion of its 7R,
    8
    R and 7S,
    8
    S epoxide derivatives. Sarcophytol K(
    8
    ) was a 13, 14-dihydroxycembranoid having a 1
    E
    ,
    3
    Z-diene moiety. The absolute configuration of
    8
    and its 1Z,
    3
    E
    - and 1Z,
    3
    Z-isomers sarcophytol
    B
    (2) and J (10) were determined by circular dichroism study of their bis-p-dimethylaminobenzoate derivatives. Sarcophytols
    F
    (11) and T (13) were 1
    E
    - and 1
    E
    ,
    3
    Z-isomers of 1. Compound 11 showed characteristic broadening of the ^1H-NMR chemical shifts, due to the restricted conformational interconversion. Using the three cembranoids sarcophytols
    F
    (11, 1
    E
    ,
    3
    E
    ), N (15, 1Z,
    3
    Z) and T (13,1
    E
    ,
    3
    Z), spontaneous autoxidation-cyclization, in CHCl_
    3
    ,was examined, in order to compare the stereochemical course of the reaction with that of 1 (1Z,
    3
    E
    ), which affords trans-fused bicyclo[
    9
    .
    3
    .0]tetradecene systems. The 1
    E
    ,
    3
    Z-isomer 13 gave the same cyclization product 18, as in the reaction of 1, even though it is isomeric at
    C
    -1,
    3
    . The 1Z,
    3
    Z isomer 15 gave 19, in consequence of the reversed geometry at
    C
    -
    3
    of 15. The 1
    E
    ,
    3
    E
    -isomer (11) gave the bicyclic product
    22
    , having an antipodal fusion as compared with 19. This was confirmed by PCC oxidation of 19 and
    22
    , giving enantiomeric ketones 23 and 24 respectively. The 1(14)-epoxide 26 was shown to be the immediate precursor of
    22
    , and acounted for the inversion of the geometry at
    C
    -1 of the cyclization product. Compound 26 is isomeric with the epoxide 17 derived from 1. The epoxide 17 is the postulated precursor in the conversion of 13 to 18. It is noteworthy that the mode of antipodal fusion of the cyclopentane rings, in 18 and
    22
    , was controlled by the chirality of the epoxy rings. The
    C
    -14 hydroxyl group participates in the transannular cyclization, but was found not to be the requisite functional group for the reaction. Similar treatment of cembrene
    C
    (30), the parent hydrocarbon of 1, also reacted in CHCl_
    3
    giving the bicyclic product 32.
  • Hideaki KISHIDA
    SOILS AND FOUNDATIONS
    1966年 6 巻 1 号 71-88
    発行日: 1966年
    公開日: 2008/02/29
    ジャーナル フリー
    Damage to reinforced concretc buildings in Niigata City due to Niigata earthquake (June 16, 1964) are analysed with special reference to foundation engineering.
  • Yasunori SAITO, Tomoyuki MARUYAMA, Hideaki YAMAKI, Fumitoshi KOBAYASHI, Takuya D. KAWAHARA, Akio NOMURA, Mitsuyoshi TANAKA
    Optical Review
    1999年 6 巻 5 号 459-463
    発行日: 1999/10/01
    公開日: 2000/03/28
    ジャーナル フリー
    Static characteristics of two different structured InAlGaAs/InAlAs superlattice avalanche photodiodes (SLAPDs) cooled by liquid nitrogen were evaluated at a wavelength of 1.
    5
    μm. The dark current of the SLAPD having a thick superlattice layer of 0.504 μm was
    5
    ×10-13 A. This was successively reduced by four orders of magnitude compared to that of the thin layer SLAPD of 0.231 μm at a breakdown voltage of around 20 V. The thickened layer was effective in suppressing tunneling dark current. An output current of 1.7×10-12 A at a bias voltage of 15 V was measured for an optical input with a wavelength of 1.
    5
    μm and a signal power of 1×10-12 W. This showed a sharp distinction from the dark current.
  • 佐藤 敬之輔
    デザイン学研究
    1970年 1970 巻 11 号 45-55
    発行日: 1970/03/30
    公開日: 2017/07/25
    ジャーナル フリー
    [1] The purpose of this reserch is to make clear what type of design can give good effects to win the high readership score. At the begining I had to know what factors decide the readership score, and how to change the quality of the desing into numerical value. I have used the method of multi-dimentional analysis with the help of a computer, and got the estimation formula, with 7 kinds of factors, as follows ; A^^〜=
    B
    +
    C
    +D+K+aE+bF+cG. A^^〜=estimated values of the readership score. 1)
    B
    ,
    C
    , D, K : these four factors are given as category values (so we call them); each factor is classified into several categories.
    B
    =week day, classified into 7 categories.
    C
    =pages of a newspaper, which are characterized by the kinds of articles, news, and the other reading matters, classified into
    22
    categories. D=kinds of goods and trades of the advertizement, classified into 14 catedories. K=constants, given to each 13 surveys. 2)
    E
    ,
    F
    , G : these factors are given as numerical values. G=area of advertizement, measured by the unit of column in the whole page length, being classified into 6 kinds of area (2.
    5
    ,
    3
    .
    5
    ,
    5
    , 7, 10, 15) and 15 column means a whole page, about 2,000cm^2.
    E
    ,
    F
    are the marks obtained in the design of advertizements.
    E
    =sum of the marks obtained in each design element on the advertizement.
    F
    =the marks obtained on the whole effect of the design.
    3
    ) a,
    b
    ,
    c
    : coefficients Using the above formula with the category values and the coefficients, we can obtain the naked design effect from the actual value A of readership score: aE+bF=A-(
    B
    +
    C
    +D+K+cG). In this research, I used 1,829 data of readership score from 1960 to 1968, being obtained by 13 survevs, spring and autumn twice a year. The sample of size each survey was
    3
    ,541, 2,251, or 200 in the other 11 surveys. Multiple correlation coefficient between the estimated value A^^〜 and the actual value A is 0.951. The table 2^* shows the contribution indexes of each factor by
    3
    kinds of expression-(1) Range : the absolute difference between the maximum and the minimum category values, (2) Standard deviations of the category values, (
    3
    ) Partial correlation coefficient : the relationship between the actual values A and each factors. *see the table 2 in the thesis in Japanese. [2] The important point was in the determination of the values of
    E
    ,
    F
    .
    E
    is the sum of the marks obtained in each design element, classified into four kinds :
    E
    =
    E
    _1+
    E
    _2+
    E
    _
    3
    +
    E
    _
    4
    . design elements [table]
    E
    _1,
    E
    _2,
    E
    _
    3
    ,
    E
    _
    4
    , these values have the
    5
    grades, as 0, 1, 2,
    3
    ,
    4
    and 0 is given to the design that has no attractive effect or no applicable element. And
    E
    obtain the marks of 0 to
    9
    grades as the sum of them. The values of
    F
    have also
    5
    grades, 0 to
    4
    . The principles to determine the values of
    E
    ,
    F
    are as follows : a) The marks obtained of
    E
    ,
    F
    must be the relative values among the each survey, and at the same time, they must have constancy within the same survey-the same elements of design must win the same marks obtained.
    b
    ) They must be determined as to win the highest multiple correlation coefficient, when they are put into the estimation formula.
    c
    ) They must be reasonable. In order to justify them, we must carry many researches on the actual condition. The frequency of accurence of each grade of
    E
    ,
    F
    values, as the table
    5
    -
    4
    , and
    5
    -
    5
    in the thesis in Japanese.
  • Yasuhiro SUGIMOTO, Kazuma SAKATOH
    IEICE Transactions on Electronics
    2013年 E96.C 巻 6 号 867-874
    発行日: 2013/06/01
    公開日: 2013/06/01
    ジャーナル 認証あり
    Circuit techniques to enhance the linearity of input-voltage-to-current (V/I) conversion and to increase the output impedance of a current source by compensating for the low intrinsic gain of a transistor were introduced to realize a high-frequency operational transconductance amplifier (OTA) for a low supply voltage using sub-100-nm CMOS processes. Applying these techniques, a MOS 7th-order Gm-
    C
    linear-phase low-pass filter (LPF) was realized using a 65nm CMOS process. A simplified biquad LPF that can serve as a component of a 7th-order LPF was newly developed by replacing OTAs with resistors. As a result, the -
    3
    dB frequency bandwidth, group delay ripple,
    3
    rd-order distortion, and
    3
    rd-order input intercept point (IIP
    3
    ) were 200MHz, 2.2%, ≤ -55dB with a 100MHz input, and +10.
    3
    dBm, respectively, all with a ±0.1Vp-p input signal at each input terminal in the pseudodifferential configuration. The LPF including an output buffer dissipated 60mW in the case of a 1.2V supply. Wide spurious-free dynamic range (SFDR) characteristics were confirmed up to high frequencies.
  • Takefumi Hattori, Hiromitsu Tsuzuki, Hiroe Amou, Kumio Yokoigawa, Masanori Abe, Akira Ohta
    Mycoscience
    2016年 57 巻 3 号 181-186
    発行日: 2016年
    公開日: 2023/03/07
    ジャーナル オープンアクセス

    A biosynthetic pathway for (

    E
    )-methyl cinnamate formation was evaluated in Tricholoma matsutake by tracer experiments using
    13C
    - and 2H-labeled precursors. One hundred percent selective
    13C
    incorporation was observed when L-[1,2,
    3
    ,
    4
    ,
    5
    ,6,7,
    8
    ,
    9
    -
    13C9
    , 15/N]phenylalanine was converted to (
    E
    )-[1,2,
    3
    ,
    4
    ,
    5
    ,6,7,
    8
    ,
    9
    -
    13C9
    ]cinnamate and (
    E
    )-[1,2,
    3
    ,
    4
    ,
    5
    ,6,7,
    8
    ,
    9
    -
    13C9
    ]methyl cinnamate. Similarly, 100% selective
    13C
    incorporation was observed when (
    E
    )-[1,2,
    3
    ,
    4
    ,
    5
    ,6,7,
    8
    ,
    9
    -
    13C9
    ]cinnamate was converted to (
    E
    )-[1,2,
    3
    ,
    4
    ,
    5
    ,6,7,
    8
    ,
    9
    -
    13C9
    ]methyl cinnamate. In contrast, the 2H incorporation selectivities were 82.1% and
    81
    .
    4
    % when L-[2,
    3
    ,
    4
    ,
    5
    ,6,7,7,
    8
    -
    2H8
    ]phenylalanine was converted to (
    E
    )-[2,
    3
    ,
    4
    ,
    5
    ,6,7,
    8
    -2H7]cinnamate and (
    E
    )-[2,
    3
    ,
    4
    ,
    5
    ,6,7,
    8
    -2H7]methyl cinnamate, respectively. Thus, T. matsutake synthesizes (
    E
    )-methyl cinnamate from L-phenylalanine via (
    E
    )-cinnamate. (
    E
    )-cinnamate was likely formed through two pathways: one was major and the other was a minor.

  • LIVIO SIROVICH
    地盤工学会論文報告集
    1996年 36 巻 4 号 23-34
    発行日: 1996/12/15
    公開日: 2008/02/29
    ジャーナル フリー
    Repetitive liquefactions in angular and subangular gravels from an alluvial fan, in the case of two earthquakes with accelerations lower than that of a former which had caused liquefaction some months before, are described. The liquefaction took place from the surface, down to a depth of approximately 10 m. Water laden with sediments spouted out for some tens of minutes after the strong motion ceased. Knowledge of the grain size distribution of the sediments inside the body of the alluvial fan roughly defines the areas of the fan prone to future liquefaction. Non-repetitive liquefaction in overconsolidated fine fluvio-lacustrine sand of glacial origin at the unusual depth of 14 m to 16 m is also described. From the observation of sand lifted up for 10 m inside a large diameter well, and of that which spouted out from several microvents, it was estimated that extra-pore pressure was close to lithostatic conditions. Nevertheless, modeling of intrinsic pore pressure buildup on the DESRA2 programme gives lower values than the experimental one. Geotechnical characteristics of the 12 m-thick sandy stratum indicate that the upper part is unusually soft, either due to water circulation or past repetitive liquefactions which prevented reconsolidation. It is suggested that excess pore pressure generated by the earthquake was also due to redistribution of pressure from adjacent sediments.
  • Mohd Suhail, Mohd Faizul Suhail, Hina Khan
    Journal of Clinical Biochemistry and Nutrition
    2008年 43 巻 3 号 210-220
    発行日: 2008年
    公開日: 2008/10/31
    ジャーナル フリー
    We compared three groups of pregnant women: placebo with normotensive women, group A which included preeclamptics, and group
    B
    which comprised preeclamptics who were supplemented their diets with vitamins
    C
    and
    E
    . MDA increased from 6.
    22
     ± 2.
    8
    (placebo) to
    8
    .48 ± 1.2 (A) and
    8
    .02 ± 1.
    8
     nmol/gHb (
    B
    ). NO concentrations were enhanced from 19.
    3
     ± 
    4
    .2 (P) to 23.
    8
     ± 6.
    4
    (A) and 24.1 ± 
    5
    .
    4
     μmol/L (
    B
    ). GSH contents were decreased from 10.42 ± 2.
    81
    (P) to
    8
    .02 ± 2.92 (A) and
    9
    .39 ± 1.02 μmol/g Hb (
    B
    ), whereas GSSG concentrations increased from 0.98 ± 0.28 (P) to 1.24 ± 0.29 (A) and 1.08 ± 0.12 μmol/g Hb (
    B
    ). SOD activity decreased 23% in A and 14% in
    B
    ; GRx decreased 27% in A and
    5
    .
    5
    % in
    B
    ; GPx decreased 12% in A and
    9
    .6% in
    B
    . Catalase activity, however, increased 27% in A and 29% in
    B
    as compared to control. Thus, we conclude that the use of vitamins
    C
    and
    E
    should be considered for the control of certain important biochemical indices during the development of preeclampsia; however, further studies are needed to develop methods for the prevention of preeclampsia in women at high risk.
  • 山本 雅史, Abkenar Asad Asadi, 松本 亮司, 根角 博久, 吉田 俊雄, 國賀 武, 久保 達也, 冨永 茂人
    園芸学会雑誌
    2007年 76 巻 1 号 36-40
    発行日: 2007年
    公開日: 2007/03/06
    ジャーナル フリー
    カンキツ主要12種を用いて染色体のクロモマイシン
    A3
    (CMA) 染色を行った.染色体は CMA(+) バンドの有無および位置から 7 種類に区分できた.すなわち,CMA(+) を A: 両端および動原体近傍に有する,
    B
    : 一方の端部と動原体近傍に有する,
    C
    : 両端に有する,D: 一方の端部に有する,
    E
    : CMA(+) がない,
    F
    : 動原体近傍に有する,Dst: 付随染色体を有する D 型,である.各種はこれらのうち 2~6 種類の染色体を有し,独自の CMA バンドパターンを示した.
    C
    . medica
    では 2
    B
    +
    8
    D +
    8
    E
    C
    . limon
    では 1
    B
    + 1
    C
    +
    8
    D +
    8
    E
    C
    . aurantifolia
    では 2
    B
    +
    9
    D + 7
    E
    C
    . aurantium
    では 1A + 1
    B
    + 1
    C
    + 7D +
    8
    E
    C
    . sinensis
    では 2
    B
    + 2
    C
    + 7D + 7
    E
    C
    . maxima
    では
    3
    A +
    3
    C
    +
    4
    D +
    8
    E
    C
    . paradisi
    では 2A +
    3
    C
    + 6D + 7
    E
    C
    . ichangensis
    では 2
    B
    + 2
    C
    + 12D + 2
    E
    C
    . latipes
    では 2A +
    5
    C
    +
    8
    D +
    3
    E
    C
    . micrantha
    では 1
    B
    + 11D +
    4
    E
    + 2Dst,
    C
    . macroptera
    では 2
    B
    + 1
    C
    + 11D +
    3
    E
    + 1
    F
    C
    . hystrix
    では
    3
    B
    + 1
    C
    +
    8
    D +
    3
    E
    + 2
    F
    + 1Dst であった.
  • ―特にアポ蛋白Eの変化について―
    本間 康彦, 三神 美和, 佐藤 美智子, 石原 仁一, 吉川 広, 木下 栄治, 田川 隆介, 星合 充基, 古屋 秀夫, 井出 満, 田辺 晃久, 玉地 寛光, 兼本 成斌, 友田 春夫, 中谷 矩章, 五島 雄一郎
    動脈硬化
    1984年 12 巻 3 号 599-603
    発行日: 1984/08/01
    公開日: 2011/09/21
    ジャーナル フリー
    Seven hundred fifty mg of cholesterol were fed daily to 32 patients of the ischemic heart disease (IHD) for 2 weeks. Cholesterol amounts in VLDL, LDL, HDL, HDL2 and
    HDL3
    were estimated on the 0th, 7th and 14th days of cholesterol load. Plasma apoprotein A-I, A-II,
    B
    ,
    C
    -II,
    E
    levels were also measured in 16 from 32 IHD subjects. Apoprotein levels were estimated by a method of single radial immunodiffusion (SRID). Before cholesterol administration, cholesterol amounts in VLDL, LDL, HDL, HDL2 and
    HDL3
    were 15.
    9
    ±7.
    5
    mg/dl (mean±SD), 150.
    9
    ±58.1mg/dl 43.
    8
    ±
    9
    .6mg/dl, 16.
    4
    ±
    5
    .
    8
    mg/dl and 24.
    9
    ±6.
    3
    mg/dl respectively. Plasma apoprotein A-I, A-II,
    B
    ,
    C
    -II and
    E
    levels were
    81
    .7±
    22
    .0 mg/dl, 15.1±
    5
    .
    4
    mg/dl, 93.7±36.0mg/dl,
    3
    .83±1.00mg/dl and
    4
    .29±1.36mg/dl respectively. After 2 weeks' cholesterol feeding, all plasma lipoprotein cholesterol and apoprotein levels did not change significantly. Correlation coefficients between plasma apoprotein and lipoprotein cholesterol levels were calculated. Apoprotein A-I and A-II correlated with HDL-
    C
    (r=0.348), HDL2-
    C
    (r=0.612) and
    HDL3
    (r=0.569). Apoprotein
    B
    correlated with total cholesterol (TC) (r=0.610), VLDL-
    C
    (r=0.341), LDL-
    C
    (r=0.726), HDL-
    C
    (r=0.432) and HDL2-
    C
    (r=0.465). Apoprotein
    C
    -II correlated with TC (r=0.765), TG (r=0.679), VLDL-
    C
    (r=0.651), LDL-
    C
    (r=0.461) and HDL2-
    C
    (r=0.326). Apoprotein
    E
    correlated with TC (r=0.580), TG (r=0.575) and VLDL-
    C
    (r=0.666). Interapoprotein's correlations were also calculated. Apoprotein A-I correlated with apoprotein A-II (r=0.468). Apoprotein
    B
    correlated with apoprotein
    C
    -II (r=0.393). Apoprotein
    C
    -II correlated with apoprotein
    B
    (r=0.393) and
    E
    (r=0.549). Apoprotein
    E
    only correlated with apoprotein
    C
    -II (r=0.549).
  • Hatem Abdel-Kader Abdel-Aziz, Wagdy Mohamed Eldehna, Mohamed Fares, Tilal Elsaman, Marwa Mostafa Abdel-Aziz, Dalia Hussein Soliman
    Biological and Pharmaceutical Bulletin
    2015年 38 巻 10 号 1617-1630
    発行日: 2015/10/01
    公開日: 2015/10/01
    [早期公開] 公開日: 2015/07/08
    ジャーナル フリー HTML
    In this study, we synthesized two series of novel
    5
    -nitrofuran-2-carbohydrazides 21ah and
    22a
    e
    in addition to a third series of thiophene-2-carbohydrazides 23ag to develop potent antimicrobial and/or antitubercular agents. The newly synthesized compounds were evaluated in vitro for their antimicrobial and antimycobacterial activities. Most of the
    5
    -nitrofuran-2-carbohydrazides 21ah and
    22a
    e
    displayed variable activity against Aspergillus fumigates, Staphylococcus aureus, Streptococcus pneumonia, Bacillis subtilis, Salmonella typhimurium, Klebsiella pneumonia, Escherichia coli and Mycobacterium tuberculosis. The sulfonamide derivative
    21f
    exhibited superior potency and broad-spectrum antimicrobial activity with minimum inhibitory concentration (MIC)=0.06–0.98 µg/mL and antimycobacterial activity with MIC=
    3
    .
    9
     µg/mL. The
    5
    -nitrofuran-2-carbohydrazides 21a,
    b
    , g, h and
    22a
    c
    exhibited significant antibacterial activity with MIC values in the range of 0.12–7.
    81
     µg/mL. The significances of the
    5
    -nitrofuran moiety and sulfonamide function were explored via the structure–activity relationship (SAR) study. In addition, docking studies revealed that the p-amino benzoic acid (PABA) and binding pockets of the dihydropteroate synthase (DHPS) were successfully occupied by compound
    21f
    . Furthermore, two quantitative structure–activity relationship (QSAR) models were built to explore the structural requirements which controlled the activity.
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