The binding of penicillin G and other 29 antibiotics to the bovine plasma proteins, a part of the pharmacokinetics of antibiotics, was investigated by the ultrafiltrating technique at
4
°C.
As the rates of the binding, inactivation, recovery and binding activity, following values were obtained in order : 64. 9 to 82.
7
%, 11.
96
to 56. 85%,
7
. 77 to 25. 75% and 8. 9 to 34. 11% in penicillin antibiotics; 0 to 61.
4
%, 0 to 10. 66%, 0. 49 to 12. 8% and 14.
91
to 41. 72% in glycoside antibiotics;
91
. 0 to 99. 9%, 16. 0 to 46. 19%, 44. 98 to 71. 01% and
4
. 33 to 21. 06% in tetracycline antibiotics; 55.
22
to 94. 1%,
5
. 37 to 57. 36%, 1. 32 to 31.
5
% and 9. 66 to 40. 65% in macrolide antibiotics; and 72.
6
to 95. 68%, 14. 34 to 51. 85%, 8. 19 to 30. 12%, and 17. 28 to 41. 54% in chloramphenicol antibiotics, respectively.
Optimum pH of the binding of antibiotics to the plasma proteins was in the range
5
. 0 to 8. 0, i.
e
. 8. 0 in penicillin antibiotics,
5
. 0 in glycoside antibiotics,
7
. 0 to 8. 0 in tetracycline antibiotics,
6
. 0 to
7
. 0 in macrolide antibiotics, and
7
. 0 to 8. 0 in chloramphenicol antibiotics, respectively.
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