The ability of Climacodon septentrionalis to immobilize and kill a mycophagous nematode (Aphelenchoides sp.) in vitro is described for the first time. Two isolates produced droplets (20–45 μm in diameter) that formed at the apices of tall, stalked, and branching secretory cells (700–1,500 μm tall). On 2% modified malt extract agar, nematodes became enveloped in the droplets, which restricted their ability to move and resulted in complete immobilization and death within several hours of contact. The rate of decomposition of the nematodes varied considerably, with most individuals persisting for weeks whereas others were degraded within several days and appeared to be colonized by dense hyphal growth. This study provides the first documentation of a non-agaricoid fungus producing secretory cells that are able to immobilize nematodes.

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Two new partially saturated tricyclic ring systems, , a, , , , 10, 10a, 11-octahydro-11-oxodibenz [, ] oxepins (a and ), and -thiepins (a and ) were synthesized. Compounds a and were desulfurized to give a pair of isomeric 2-methylbenzoylcyclohexanes (10a and 10). Deuterated a and (11a and 11) were prepared starting from butadiene- (12). The stereochemical features of a (trans), (cis), a (trans) and (cis) are compared with those of 10a, 10, 11a and 11 on the basis of proton nuclear magnetic resonance data.

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11-Amino-, a, , , , 10, 10a, 11-octahydrodibebenzo[, ]thiepines (a-) and -oxepines (a-) were synthesized by the Leuckart reaction of , a, , , , 10, 10a, 11-octahydro-11-oxodibenzo[, ]thiepines (1a, )and -oxepines (2a, ) followed by hydrolysis of the reaction products a- and a-, respectively. The four diastereomers, cis(a-H, 10a-H)-cis(10a-H, 11-H) a and a, cis(a-H, 10a-H)-trans(10a-H, 11-H) and , trans(a-H, 10a-H)-trans(10a-H, 11a-H) and , and trans(a-H, 10a-H)-cis(10a-H, 11-H) and , were isolated and their configurations and conformations were elucidated by chemical methods together with ¹H-nuclear magnetic resonance spectroscopic and X-ray crystallographic analyses.

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Stereoselective synthesis of the , -syn, , -anti adducts (14 and 16) on the aldol condensation of the Z (O)-lithium enolate, derived from the -enone (2), to α-alkoxy aldehydes (12 and 13) was proved via the successive intramolecular Diels-Alder reaction.

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One method currently being considered for the disposal of high level radio-active waste is burial in the seabed. When a hot object is buried in soil, the temperature of the soil adjacent to the object is raised and there is transient heat flow away from the object. The rise in the temperature of the soil causes excess pore pressures to be generated and transient pore water diffusion also takes place. A finite element formulation of the coupled heat flow and consolidation problem is presented. The computer implementation of this formulation is found to compare favourably with analytical solutions based on the same physical principles.

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2-Benzyl--chloro--mercapto- (2H)-pyridazinone (1) was heated in ethanol under reflux for 10 hours to form concurrently 2, -dibenzyldipyridazo [, - : ', '-]-1, -dithiin-1, (2H, H)-dione (Ia) (57% in yield) and 2, -dibenzyldipyridazo [, - : ', '-]-1, -dithiin-1, (2H, H)-dione (IIa) (14% in yield). Assignment of the two products to the corresponding structures is established by their physico-chemical constants and chemical behaviors. The concurrent formation of the dipyridazo [, - : ', '-]-1, -dithiin-1, (2H, H)-dione and the -1, (2H, H)-dione were observed in, not only heating -chloro--mercapto- (2H)-pyridazinones (1-) in polar solvent, but warming -mercapto--chloro- (2H)-pyridazinones (-) in the presence of potassium carbonate in DMF. For the interpretation of the reaction, keto-thioketo carbenes as active intermediate species and a reversible interconversion among them are suggested on the basis of the fact that there was nonexistence of an equilibrium between the two compounds, such as Ia and IIa, under the reaction condition and a trapping keto-thioketo carbene species as 2-phenylimino--benzylpyridazo [, -]-1, -dithiol- (H)-one (IVa) (14% in yield) along with the major products, (Ia) and (IIa), was furnished by warming 1 with phenylisothiocyanate in the presence of triethylamine in dry benzene. On the contrary, participation of a reversible interconversion between Ia and IIa, to a considerable extent, with the concurrent formation of them in the case of benzylation of either Ib or IIb, by warming with benzylchloride in the presence of potassium carbonate in DMF at 80°, might not be neglected, because an attempted approach to an equilibrium between Ia and IIa in a similar reaction condition except the use of benzylchloride realized, whereas non-existence of an equilibrium between Ib and IIb in the similar reaction condition was observed.

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わが国における主要中晩生および香酸カンキツ染色体のクロモマイシン (CMA) 染色を行った. 染色体はCMA(+) バンドの有無および位置から種類に区分できた. すなわち, CMA(+) をA: 両端および動原体近傍に有する, : 一方の端部と動原体近傍に有する, : 両端に有する, : 一方の端部に有する, : CMA(+) がない, である. 各種はこれらのうち, 種類の染色体を有し, 独自のCMAバンドパターンを示した. ハッサクでは1A+1++, ヒュウガナツでは2A+2++, ‘川野なつだいだい’では1A+2++, ‘宮内伊予柑’では1A+1+1++, タンカン‘垂水1号’では1A+1+1++, カボスでは+2++, スダチでは1+2++およびユズ‘山根’では2+1+11+であった. 以上の結果, 本研究においても近縁の種間では似通ったCMAバンドパターンが観察された.

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The possibility of attenuation of microseismic waves due to the presence of an upward folding of the ocean bottom into the liquid is discussed in this paper. The upward folding of the ocean bottom has been idealized by means of an irregularity in the form of a rectangle intruding into the liquid and the evaluation of the displacement component at any point of the solid medium has been carried out in two stages. First, the change in the incident mode of the surface wave due to the presence of the rectangular irregularity has been determined, and second, the subsequent change of the resulting displacement components due to the termination of the liquid layer and the step change in elevation of the solid medium at the continental margin has been discovered. Finally, numerical calculation has been made to determine the attenuation of the microseismic waves of different periods due to the presence of the rectangular irregularity at the ocean bottom.

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The behavior of the soft clay grounds subjected to repeated loading is different from that subjected to sustained loading. The difference in settlement between these two loading patterns should be due to secondary compression over a long period of time. Consequently, soft clay grounds subjected to repeated loading tend to be more compressible than those subjected to sustained loading. Therefore, it is necessary for engineers to predict post-construction settlements under repeated loading. In this respect, the preloading is considered to be promising as a countermeasure to reduce the settlement of clay under repeated loading as well as under sustained loading. The effect of preloading on post-construction consolidation settlement of soft clay subjected to repeated loading after removal of a part of preload is investigated in the present paper. It has become clear that the settlement of a clay sample after preconsolidation is mainly affected by the amount of preload, the degree of consolidation due to the preload, the amount of permanent load and the amount of repeated load after removal of preload. The calculated settlement versus time relations using a method to estimate the amount of consolidation settlement of soft clay grounds subjected to repeated loading after removal of preloading were compared with the observed degree of consolidation as parameters of the intensities of preload and repeated load.

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-Amino--mercapto-1, -dimethyluracil (2) was prepared by the treatment of , -diamino-1, -dimethyluracil (1) with liquid H₂S and pyridine in a sealed steel tube at 60° for 20 h. Thiazolo[, -]pyrimidinediones a, were obtained from 2 by cyclization with HCO₂H and AcOH.Under stringent conditions, however, 1 was converted into the , -dihydrodipyrimido[, - : ', '-][1, ]thiazine derivtive a.The structure of a was confirmed by spectral (nuclear magnetic resonance and mass spectra) data and by comparison with a sample which was prepared from 2 and -hydroxy-1, -dimethyluracil.Benzylation of a gave 1, , , -tetramethyl--benzyl (or p-bromobenzyl)-, -dihydrodipyrimido[, - : ', '-][1, ]thiazine-2, , , -(1H, H, H)-tetrone (, ) and 1, , , -tetramethyl--benzyl (or p-bromobenzyl)-, -dihydropyrrolo[, 2- : , -']dipyrimidine-2, , , -(1H, H, H)-tetrone (a, ).

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カンキツ主要12種を用いて染色体のクロモマイシン (CMA) 染色を行った．染色体は CMA(+) バンドの有無および位置から 種類に区分できた．すなわち，CMA(+) を A: 両端および動原体近傍に有する，: 一方の端部と動原体近傍に有する，: 両端に有する，: 一方の端部に有する，: CMA(+) がない，F: 動原体近傍に有する，Dst: 付随染色体を有する 型，である．各種はこれらのうち 2～ 種類の染色体を有し，独自の CMA バンドパターンを示した．

C

. medica では 2 + + ，

C

. limon では 1 + 1 + + ，

C

. aurantifolia では 2 + + ，

C

. aurantium では 1A + 1 + 1 + + ，

C

. sinensis では 2+ 2 + + ，

C

. maxima では A + + + ，

C

. paradisi では 2A + + + ，

C

. ichangensis では 2 + 2 + 12 + 2，

C

. latipes では 2A + + + ，

C

. micrantha では 1 + 11 + + 2Dst，

C

. macroptera では 2 + 1 + 11 + + 1F，

C

. hystrix では + 1 + + + 2F + 1Dst であった．

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In view of the significant role of the water film effect in flow failure for a liquefied sandy deposit, the mechanism of water film generation is numerically studied based on a 1-dimensional model test. The process of water film growth and decay can be simulated to a certain extent by a simple consolidation analysis, which indicates that only a small difference in permeability in layered sand is enough for a water film to develop. A 1 G shaking table test for a two-dimensional slope model with an arc of silt within a saturated sand is then addressed to discuss the dilatancy effect exerted in sheared sand during flow failure. It is possible that, once the water film is formed, the transmission of shear stress through it is interrupted, leaving the sand below free from the dilatancy ; this eventually allows the water film to stay without being absorbed during flow failure. The result of another shaking table test for a trapezoidal slope with horizontal silt seams indicate that water films beneath the seams enable the soil mass above them to laterally flow along water films very gently inclined even after shaking. If a silt seam breaks due to excessive pressure in the water film, it triggers re-liquefaction in the upper sand and leads to further instability.

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A sample of [

3H

] tobrarnycin (

5

, 000 Ci/Mole) has been synthetized and incubated with
the bacterial ribosome and its subunits. The results obtained show that this antibiotic has
two types of binding sites. The primary one is probably responsible for the inhibition of
protein synthesis whereas the secondary one is probably related to the misreading and reading
tiirough of the messenger RNA.

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All the birds examined were also associated with bone dysplasia (art alczaormal develop-ment of bone tissue) in the diaphyseal cortex of the leg bones, especially of bones affectedwith dyschondroplasia. This result is very significant in order to clarifyz tlais disease entity.1970:J14, k -1 } ) , M77 ) i? ht /, ( K ) ( # L", MB @ () t, If!TB& U ", Jff Dyschondroplasia (1*t%fi!dW) ().g:#f[!:.fLlt! K?o, [1: ()M;tC, rff.?U/:cD, =1lC#li*H(DX15RI!!& t, r, ccl)Efffflr.#.??t"ut:2.?T<.1.?l?F?/?t:>"A??1!? > >?TMOll?, lI]%G (f-srRM) -ts;;.*BI) *M[t fL 54 t:.;*.{1*I[l?(), t@Yllll*fJ?H@() %?Jfipj@ (Dyschondroplasia) p, }, (, 1lTi{-X, WIKIM itt{= t "tl%tff{tO 1111IH(-UP!z U-ii) >ES- -)%Wi*fd?1J*[lEj: >11"iifI".*"H*Tl*&Z") #)/2?-"k l - vich ) J&it(VhiO"= >If-ffi"!1lYl*I")Ji/l![40111!>*F!)<Y14M)?A"!>CL(Il], k.ClT"ltTt*flB1? & $U [-" U" L % w, Zl1*.IlBl tI1J, FA(y L-x") LVfAK t: >llltPJIiI " } ) t- ! Al j: >kP11liR, &ffl(NWi Z lk(#L" Ct ?f!M2"- fL#, -()%.IWMd1.XI1*I1EPW(tit ff1lR)

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フォローアップ検査がなされた2,740例（61.

±37.月，.33±1.64回）を初回所見別にA群：正常大腸633例，群：微小腺腫放置721例，群：低異型度腺腫切除622例，群：高異型度腺腫，粘膜内癌切除307例，群：浸潤癌切除457例に分類し後ろ向きに検討した．異時性の低異型度腺腫，高異型度腺腫または癌（Index lesion）の累積発生率は，Kaplan-Meier法によるLogrank検定にて，両者ともA群，群，群，群の順に段階的に有意に増加した．しかし低異型度腺腫は群で有意に減少した．年未満，年未満のIndex lesion発生率はA群1.％，1.％，群2.％，.2％，群.2％，.％，群.0％，.％，群.％，.％であった．％を許容頻度とすれば，A，，群は年間は許容され群は年間，群は年間で許容頻度を超えた．

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