Pharmacokinetics and bioavailability of
2
multivitamin preparations including
B
_
1
,
B
_
6
,
B
_<12> and/or
E
were studied in human male volunteers. The same dosage of 100 mg thiamine tetrahydrofurfuryl disulfide (
B
_
1
) was included in both preparations. However, one preparation (Alinamin EX^<(R)>) included high amounts of 100 mg pyridoxine hydrochloride (
B
_
6
), 1500 μg hydroxocobalamin (
B
_<12>) and 100 mg d, l-α-tocopherol succinate (
E
). The other (Alinamin A50^<(R)>) included 10 mg riboflavin (
B
_
2
), 10 mg pyridoxine hydrochloride (
B
_
6
), 20 μg cyanocobalamin (
B
_<12>). the results were as follows :
1
)
B
_
1
: No difference was observed between AUC of both preparations. T_<max> tended faster in Alinamin EX^<(R)>.
2
)
B
_
6
: AUC by administration of Alinamin EX^<(R)> was
9
times larger than in Alinamin A50^<(R)>. 3)
B
_<12> : AUC by administration of Alinamin EX^<(R)> was 4 times larger than in Alinamin A50^<(R)>. 4)
E
: A significant increase in plasma was observed by administration of Alinamin EX^<(R)>. AUC represents the area under curve obtained from the blood drug concentration of the time course.
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