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  • NACE Technical Unit Committee T-
    6
    B
    , T-
    6
    B
    -
    3
    , 松見 信, 松永 孝雄
    防蝕技術
    1967年 16 巻 10 号 426-431
    発行日: 1967/10/15
    公開日: 2009/11/25
    ジャーナル フリー
  • 片山 透, 上司 裕史
    医療
    1991年 45 巻 11 号 1055-1059
    発行日: 1991/11/20
    公開日: 2011/10/19
    ジャーナル フリー
    Chiron社が開発した
    C
    100-
    3
    抗体検査法は,
    C
    型肝炎ウイルスの診断薬として一応定着した. 赤十字血液センターは, すでに1989年11月から, この検査を献血のスクリーニングに追加している. ウイルス遺伝子の非構造部分から作られた
    C
    100-
    3
    を第一世代の検査法と名付ければ, 内外のその後の研究進展により, すでに第二世代の検査法というべきものが検討されており, 正式承認も間近い. 東京病院で手術に際して輸血が行われた症例において, 1984年から1989年までの輸血後非A非
    B
    型肝炎発症率は12.4%であり, そのうち
    C
    100-
    3
    抗体陽性の血液の輸血後の発症は56.
    3
    %を占めた. しかし1990年には肝炎発症率は5.
    6
    %に下がり, このことは従来の輸血後肝炎発症例のうちの54.8%が発生しなくなったということで, 上述の56.
    3
    %に近似する. この数値は第二世代の検査法によりさらに下がるであろう.
  • -余裕教室利用の進む京都市を事例として-
    吉田 哲, 山﨑 悠祐, 岩田 伸一郎, 白旗 勇太
    日本建築学会計画系論文集
    2021年 86 巻 783 号 1377-1386
    発行日: 2021/05/30
    公開日: 2021/05/30
    ジャーナル フリー

    For the elderly living in residential areas on the urban fringe, easy access to public and life services is important. In this paper, we made it clear principals’ tolerance of (A) time,

    B
    ) users, and
    C
    ) position to general classrooms) for community use of surplus classrooms in elementary schools (total
    22
    uses from I. circle use, II. social gatherings use, and III. community services).

     

    Analysis 1: 36 combinations of the three variables(A),

    B
    ),
    C
    )) are obtained by cluster analysis, and we use these combinations as Tolerance ID (TID) for each use.

    In I-1. quiet circle, except for (1) meeting, more than half of principals belong to (a) another building/ (

    b
    ) afterschool/ (
    b
    ) community organization members (TID8) or (
    c
    ) registered persons (TID10), and the remaining 30-40% belong to TID19- (a) another building, (
    c
    ) same floor_separate/ (d) weekday during class/ (
    b
    ) community organization members, (
    c
    ) registered persons.

    In II. social gatherings use, TID1-incompatible in school building is less than 30% in (10) tea party, just under half in (11) gathering w/ eat. 40% of both remainder are included in TID

    3
    -(a) another building/ (a) holiday/ (
    b
    ) community organization members, (
    c
    ) registered persons.

    In III-1. public service, the proportion of TID1-incompatible is more than 60-70%, but (13) residents’ association office is half and the remainder is less than half in TID13-(a) another building/ (

    b
    ) afterschool, (d) weekday during class/ (d) general residents.

     

    Analysis 2: By cluster analysis using two-dimensional discriminant measures obtained from multiple correspondence analysis with TID as a nominal variable,

    22
    uses are categorized into five usage types. I-1. quiet circle, except for (1) meeting and (2) study, makes 1st
    Gr
    . All I-2. circle w/ sound makes 2nd
    Gr
    . III. community service, except for (13) residents’ association office and (18) community library, makes 5th
    Gr
    . In addition to this,
    3
    rd
    Gr
    is made by (1) meeting and (10) tea party, and we named this
    3
    rd
    Gr
    as “conventional meeting use”. (2) study and (13) residents’ association office, (18) community library added to II. social gathering use make 4th
    Gr
    and we named this 4th
    Gr
    as “transitional community use”.

     

    Analysis

    3
    : By cluster analysis using object scores obtained simultaneously in Analysis 2, we got the six groups (Group A-F) of tolerance clusters (CL) of school principals.

    Group A shows TID1-incompatible in school buildings at (12) gathering w/ alcohol and (13) residents’ association office in 4th

    Gr
    and all uses in 5th
    Gr
    .

    Groups

    B
    and
    C
    show, in all uses in 1st
    Gr
    , TID19-(a) another building, (
    c
    ) same floor separated/ (d) weekday during class/ (
    b
    ) community organization members, (
    c
    ) registered persons. Groups
    B
    and
    C
    are characterized by a relatively high level of tolerance. Furthermore, these groups also show, in 4th
    Gr
    and 5th
    Gr
    , high tolerance such as TID11~13, 18-(a) another building/ (a) holiday (d) weekday during class, or (
    b
    ) afterschool (d) weekday during class, or only (d) weekday during class/ (d) general residents.

     

    Through the principals of schools such as Groups

    B
    and
    C
    , which have a high tolerance toward community use in school building, we wonder if it would be possible to verify the community service uses during weekday classes and in separate buildings.

  • 竹崎 英一, 村上 信三, 有吉 隆久, 津田 敏孝, 松岡 恵, 香川 和徳
    医療
    1997年 51 巻 4 号 166-170
    発行日: 1997/04/20
    公開日: 2011/10/19
    ジャーナル フリー
    慢性
    C
    型肝炎患者に対するインターフェロン治療効果をHCVコア(
    C
    22
    -
    3
    )抗体反応から検討した. 治療前血清
    C
    22
    -
    3
    抗体価は血清ALT値と有意な相関を示し, 肝の炎症活動性と比較的, 高い相関を有することが示唆された. IFN治療に対する反応を治療後
    6
    ヵ月後の血清HCV-RNA値から, 著効, 一過性反応, 無効に分けて検討すると, いずれの群でも血清
    C
    22
    -
    3
    抗体価はIFN治療中に低下する傾向を示した. したがって, IFN治療中の血清
    C
    22
    -
    3
    抗体価の変動から, これら反応群の鑑別は困難であったが, 治療後, 著効群では抗体価がさらに低下する傾向を示したのに対し, 著効群以外の群では再上昇を示した. 治療後
    6
    ヵ月後の血清
    C
    22
    -
    3
    抗体価%比79%で, 高い感度, 特異性, 信頼性で著効群とその他の群を鑑別することが可能であった.
  • 森谷 博之
    リアルオプションと戦略
    2020年 11 巻 1 号 17-22
    発行日: 2020年
    公開日: 2020/04/15
    研究報告書・技術報告書 フリー
    CTAの行政上の取り扱い、歴史、投資戦略等をまず簡単に説明する。CTAとは金融先物、オプション、スワップを対象とした取り引きに関する投資のアドバイスやサービスを個人、ファンドに提供する個人、または組織に対する金融行政上の用語で、正式名はCommodity trading advisorである。CTAという用語は投資信託、ETFを含むヘッジファンド、プライベートファンドへの投資アドバイスにも適応される。CTAs は米国連邦政府による規制対象であり Commodity Futures Trading Commission (CFTC) への登録と National Futures Association (NFA) のメンバーになることが義務付けられている。また、CTAはヘッジファンドの投資スタイルのひとつ (Global Macro) でもある。
  • E. Brondum, H. Kold-Petersen, H. Nilsson, A. Flyvbjerg,
    C
    . Aalkjaer
    The Journal of Physiological Sciences
    2008年 58 巻 5 号 333-339
    発行日: 2008年
    公開日: 2008/10/29
    [早期公開] 公開日: 2008/10/07
    ジャーナル フリー
    Type 2 diabetes is associated with many circulatory manifestations, including alteration in endothelial function and hypertension. In this study we investigate the morphology and contractile response as well as the endothelial function of resistance arteries from the spontaneously diabetic Goto-Kakizaki (GK) rat, a model of lean type 2 diabetes expressing glucose intolerance. METHODS: Isolated mesenteric small arteries were investigated under isometric conditions in a wire myograph system using noradrenaline (NA) and the endothelium-dependent vasorelaxant acetylcholine (ACh). Media thickness was measured and media lumen ratio calculated. RESULTS: No apparent morphological difference was noted between the arteries from GK rats and control Wistar (CW) rats. When exposed to the maximal NA concentration used (30 μM), arteries from GK rats developed significantly more tension than arteries from CW rats. In the presence of indomethacin (a specific blocker of the COX synthase) and of L-NAME (an inhibitor of eNOS), the response to NA was still significantly greater in GK rat arteries. Under control conditions, arteries from both groups showed intact relaxation to ACh. After incubation with indomethacin and L-NAME, both groups showed a non-NO nonprostaglandin-dependent relaxation to ACh. This relaxation could be blocked by a combination of apamin and charybdotoxin. CONCLUSION: This study shows that mesenteric small arteries from the diabetic GK rat have increased contractile response to NA, along with a normal endothelial function and unaltered morphology.
  • I. Stamenkovic, 佐藤 いずみ
    Trends in Glycoscience and Glycotechnology
    1994年 6 巻 28 号 121-132
    発行日: 1994/03/02
    公開日: 2010/01/05
    ジャーナル フリー
    CD
    22
    は成熟
    B
    細胞上に発現される
    B
    リンパ球特異的接着分子である。最近の研究で、CD
    22
    はイムノグロブリンスーパーファミリーメンバーの構造をしているものの、その機能的特質はシアル酸特異的レクチンの特質を持つことが示された。CD
    22
    のユニークさは、特異的な結合のシアル酸のみを認識し、α2,
    6
    シアル酸転移酵素によるCD
    22
    自身のシアル化によって接着分子としての機能を捨て去ることができるという報告によってはっきり示される。白血球特異的ホスホチロシンホスファターゼであるCD45もCD
    22
    によって認識されるシアロ糖タンパク質であることが発見されたことは、CD
    22
    がリンパ球活性化の制御に関係する分子かもしれないという興味深い可能性を増すものである。この総説はCD
    22
    分子とその推測される機能についての私たちの最近の知識を要約したものである。
  • YUKIO IKEDA, TADASHI SUEHIRO, SACHIE TSUZURA, TOMOKO SHIINOKI, TADAFUMI KANEDA, YOSHITAKA KUMON, KOZO HASHIMOTO
    Endocrine Journal
    2001年 48 巻 6 号 723-726
    発行日: 2001年
    公開日: 2006/11/25
    ジャーナル フリー
    Since glucocorticoid exerts its biological effects by binding to its receptor, the expression efficiency of the glucocorticoid receptor (
    GR
    ) gene could influence glucocorticoid sensitivity. We found a polymorphism of cytosine/adenine (-
    22
    C
    /A) in the upstream region of the
    GR
    gene. There was no difference in the allelic frequency between normal and type 2 diabetic subjects. The promoter activity determined by luciferase assay was significantly lower in the -
    22
    A allele than in the -
    22
    C
    allele in both HepG2 (A allele, 4.19±0.15;
    C
    allele,
    6
    .07±0.27, p<0.001) and human embryonic kidney 293 cell lines (A allele, 0.93±0.16;
    C
    allele, 1.51±0.32, p<0.001). This polymorphism is associated with transcription of the OR gene, which could be related to glucocorticoid sensitivity through an alteration in tissue OR number.
  • Ro
    22
    -8181皮膚科研究会
    西日本皮膚科
    1987年 49 巻 5 号 902-911
    発行日: 1987/10/01
    公開日: 2012/03/10
    ジャーナル 認証あり
    帯状疱疹に対するRo
    22
    -8181の有効性, 安全性および有用性を検討するため, ヒト血清アルブミンを対照薬として, 二重盲検比較試験を行つた。皮膚症状の観察項目別の改善率では, 水疱·膿疱において投与開始後5日目でRo
    22
    -8181群70%, placebo群50%で, 両群間に差(p<0.05)が認められた。皮膚症状改善度の推移を著明改善以上の症例についてみると, 投与開始後4日目の著明改善率はRo
    22
    -8181群8%, placebo群0%であり, Fisherの直接計算法で両群間に差(p<0.05)が認められた。また, 投与開始後5日目の著明改善率はRo
    22
    -8181群15%, placebo群
    3
    %であり, κ2 検定で両群間に差(p<0.05)が認められた。主治医による有効性の判定ではU検定でRo
    22
    -8181群が優れている傾向が認められた。主治医による安全性の判定では副作用発現率がRo
    22
    -8181群83%, placebo群14%であり, U検定で両群間に差(p<0.001)が認められた。主治医による有用性の判定ではU検定で両群間に差は認められなかつた。以上の結果より, 帯状疱疹に対し, Ro
    22
    -8181は皮疹のうち水疱·膿疱に対して有効であり, 主治医判定でも有効性が認められたが, 安全性については本薬剤の耐薬性が示されたものの副作用の発現率が高かつたため, 有用性は高くないと考えられた。
  • 山川 肇
    廃棄物資源循環学会誌
    2011年 22 巻 3 号 199
    発行日: 2011年
    公開日: 2015/03/31
    ジャーナル フリー
  • Xue Bai, Jie Sun, Weiwei Wang, Zhongyan Shan, Hongzhi Zheng, Yushu Li, Yuhang Zhao, Ming Gong, Weiping Teng
    Endocrine Journal
    2014年 61 巻 12 号 1181-1190
    発行日: 2014年
    公開日: 2014/12/25
    [早期公開] 公開日: 2014/09/20
    ジャーナル フリー
    As Th
    22
    subsets are identified, their involvement in the pathogenesis of numerous autoimmune diseases has become apparent. In this study, we investigated differentiation of Th
    22
    cells in the autoimmune thyroid diseases including Hashimoto’s thyroiditis (HT) and Graves’ disease (GD). Besides, we also explored the involvement of Th
    22
    cells in an iodine-induced autoimmune thyroiditis (AIT) model (i.e., NOD.H-2h4 mice). In HT patients, we showed the level of circulating Th
    22
    cells correlated with the level of serum IL-
    22
    , and was significantly higher than in GD patients and healthy control subjects. Levels of serum IL-
    6
    , a major Th
    22
    cell differentiation effector, were also higher in HT, and correlated with Th
    22
    cells concentration. Peripheral blood mononuclear cells isolated from HT patients produced larger amounts of IL-
    6
    in vitro than did those isolated from other groups. Furthermore, unlike those from GD patients, T lymphocytes from HT patients showed an enhanced differentiation in vitro into Th
    22
    cells in the presence of recombinant IL-
    6
    and TNF-α. In addition, levels of circulating Th
    22
    cells and titers of thyroid peroxidase antibody were positively correlated in HT patients. In NOD.H-2h4 mice, higher numbers of Th
    22
    cells were observed in the spleens of the AIT group, while splenocytes of this group also produced larger amounts of IL-
    6
    and IL-
    22
    in vitro compared with the control. Intra-thyroid infiltrating IL-
    22
    + lymphocytes were significantly increased in mice of the AIT group compared with the control. Our results indicate that Th
    22
    cells may contribute to the pathogenesis of HT.
  • Toshiyuki OHNISHI, Bunta WATANABE, Kanzo SAKATA, Masaharu MIZUTANI
    Bioscience, Biotechnology, and Biochemistry
    2006年 70 巻 9 号 2071-2080
    発行日: 2006/09/23
    公開日: 2006/09/23
    [早期公開] 公開日: 2006/09/07
    ジャーナル フリー
    We characterized a new cytochrome P450 monooxygenase (P450), CYP724
    B
    2, from tomato (Lycopersicon esculentum). CYP724
    B
    2 showed 42% and 62% amino acid sequence identity with Arabidopsis DWARF4/CYP90
    B
    1 and rice DWARF11/CYP724
    B
    1 respectively. Functional assay of CYP724
    B
    2 heterologously expressed in insect cells revealed that CYP724
    B
    2 catalyzes
    C
    -
    22
    hydroxylation of campesterol, indicating that CYP724
    B
    2 is a
    C
    -
    22
    hydroxylase. We also isolated a tomato CYP90
    B
    homolog (CYP90
    B
    3
    ) and found that CYP90
    B
    3
    is a
    C
    -
    22
    hydroxylase as well. CYP724
    B
    2 and CYP90
    B
    3
    showed substrate specificities similar to each other toward the biosynthetic intermediate compounds from campesterol to campestanol. Campesterol was the best substrate, and (24R)-ergost-4-en-
    3
    -one was also metabolized to the
    C
    -
    22
    hydroxylated product to some extent. On the other hand, the P450s catalyzed
    C
    -
    22
    hydroxylation of (24R)-5α-ergostan-
    3
    -one and campestanol at a trace level, indicating that the compounds after
    C
    -5α reduction are poor substrates of CYP724
    B
    2 and CYP90
    B
    3
    . In addition, cholesterol (
    C27
    sterol) and sitosterol (
    C29
    sterol) were also converted to
    C
    -
    22
    hydroxylated products by the P450s. Furthermore,
    CYP724B2
    and
    CYP90B3
    genes were ubiquitously expressed, and their transcript levels were down-regulated by the exogenous application of brassinolide. These findings strongly suggest that CYP724
    B
    2 and CYP90
    B
    3
    function in the early
    C
    -
    22
    hydroxylation steps of brassinosteroid biosynthetic pathway in tomato.
  • 森 弘, 柴田 健雄, 常田 清, 沢井 政信
    天然有機化合物討論会講演要旨集
    1968年 12 巻 27
    発行日: 1968/09/20
    公開日: 2017/08/18
    会議録・要旨集 フリー
    Klyne and Stokes reported that the hydroxyl group at
    C
    -
    22
    in natural
    22
    -hydroxycholesterol (26) is α_F-oriented. In connection with studies on the synthesis of ecdysone in our laboratory, it was found that this assignment should be reversed. Lactone A (
    3
    ) and
    B
    (4) were prepared from stigmasterol (1) by eight steps of reactions as key, intermediates for the synthesis of ecdysone and its isomer at
    C
    -
    22
    (41). These lactones were introduced into diol A (5) and
    B
    (
    6
    ), respectively, which were also synthesized from stigmasterol by another route. 5α-Cholestane-
    3
    β,
    22
    -diol (15a), in which the configuration at
    C
    -
    22
    is apparently different from that of natural
    22
    -hydroxycholesterol, was obtained by transformations from diol A (5). (Chart 2) The similar treatment of diol
    B
    (
    6
    ) afforded 5α-cholestane-
    3
    β,
    22
    -diol (25
    b
    ) identical with the hydrogenation product of natural
    22
    -hydroxycholesterol. (Chart
    3
    ) On the other hand,
    22
    -isoecdysone (41) was synthesized from lactone A (
    3
    ) (Chart 4), and ecdysone from lactone
    B
    (4). Thus, the configuration of the
    22
    -hydroxyl group in natural
    22
    -hydroxycholesterol is the same as that of ecdysone. If the configuration assigned in ecdysone is considered to be unequivocal, natural
    22
    -hydroxycholesterol must be formulated as 5-cholestene-
    3
    β,
    22
    β_F-diol.
  • Nobutoshi TANAKA, Ken-ichi HOSOI, Daizo TANAKA, Mimei TAKAHASHI
    Chemical and Pharmaceutical Bulletin
    1996年 44 巻 4 号 843-846
    発行日: 1996/04/15
    公開日: 2008/03/31
    ジャーナル フリー
    Chemical properties of ergosta-4,
    6
    , 8(14),
    22
    -tetraen-
    3
    -one (1) were investigated. Though 1 is rather stable to acids or bases, it reacts easily with two moleculres of oxygen on irradiation with UV light to give
    , 9α-epidioxy-14α-hydroperoxyergosta-4, 7,
    22
    -trien-
    3
    -one (2), which is transformed successively to
    , 7α;8α, 9α-diepoxy-14α-hydroperoxyergosta-4,
    22
    -dien-
    3
    -one (
    3
    ) and 14α-hydroperoxy-9α-hydroxyergosta-4, 7,
    22
    -triene-
    3
    ,
    6
    -dione (4) under these reaction conditions.
  • Peter Hiscooks
    産学官連携ジャーナル
    2005年 1 巻 9 号 56-61
    発行日: 2005/09/15
    公開日: 2024/05/14
    ジャーナル フリー
  • The Japan Society for Occupational Health May
    22
    , 2019
    Environmental and Occupational Health Practice
    2019年 1 巻 2 号 61-94
    発行日: 2019年
    公開日: 2019/12/28
    [早期公開] 公開日: 2019/12/04
    ジャーナル フリー HTML

    The Japan Society for Occupational Health (JSOH) recommends the Occupational Exposure Limits (OELs) as reference values for preventing adverse health effects on workers caused by occupational exposure to chemical substances, continuous or intermittent noise, impulsive or impact noise, heat stress, cold stress, whole-body vibration, hand-arm vibration and time-varying electric, magnetic and electromagnetic fields and ultraviolet and ionizing radiation.

  • A. SRIVASTAVA, H.P. GUPTA, I.S. MATHUR, S.K. GUPTA
    The Journal of General and Applied Microbiology
    1971年 17 巻 3 号 251-257
    発行日: 1971年
    公開日: 2006/08/16
    ジャーナル フリー
    Intracerebral injection of vegetative myxamoebae of strains of Polysphondylium pallidum caused 80 to 100% mortality in mice, whereas a 30 to 50% mortality occurred with strains of Dictyostelium giganteum and D. mucoroides. Death is attributable to an unidentified toxic factor. Histopathologically a giant cell formation was seen in the spleen of mice. This cell was different from Langerhan's or foreign body giant cell. Rats injected intracerebrally behaved similarly. Intranasal instillation of myxamoebae in guinea pigs caused transient pneumonia. Myxamoebae do not multiply in the brain tissues of mice or rats, or in the lungs of guinea pigs.
    Intranasal instillation of vegetative myxamoebae is less pathogenic than free living amoebae like Hartmanella culbertsoni, H. rhysodes, Naegleria sp. (Culbertson strain HB-1), or Naegleria aerobia.
  • 22
    回日本コンピュータ外科学会大会座長
    日本コンピュータ外科学会誌
    2013年 15 巻 3 号 293-296
    発行日: 2013/11/15
    公開日: 2014/03/31
    ジャーナル フリー
  • S. Kimura, M. Minami, N. Hamaue, T. Endo, M. Hirafuji, H. Saito, N. Nakamura, M. Yamada
    Japanese Heart Journal
    1995年 36 巻 4 号 537
    発行日: 1995年
    公開日: 2008/12/09
    ジャーナル フリー
  • 伊藤 義康, 友田 憲次, 湯浅 良孝
    材料
    1987年 36 巻 405 号 549-555
    発行日: 1987/06/15
    公開日: 2009/06/03
    ジャーナル フリー
    Electron beam welding was used to weld a SUS 405 steel plate with A387
    Gr
    .
    22
    , A204
    Gr
    .
    B
    and SS41 steel plates. Compact tension type specimens (0.
    6
    T-CT) with incomplete penetration notches were extracted from the electron beam welds. Fracture toughness tests were carried out at room temperature for the specimens in the as-welded and post-weld heat-treated (685°
    C
    ×2, 4 and 8 hours) conditions.
    The welded joints of A387-SUS 405 and A204-SUS 405 gave higher fracture toughness when PWHT was applied. Those of SS41-SUS 405 gave lower fracture toughness when PWHT was applied. The fractographic and sectioning observation of specimens indicated that the fracture toughness of the welded dissimilar metal joints was affected by the crack path deflection caused by the heterogeneity of welds and ferrite bands. In the welded joint of A387-SUS 405, the crack propagated right through the weld metal which was tempered by PWHT. When a long time PWHT was applied, the crack deflected from the weld metal toward the ferrite band in both the welded joints of A204-SUS 405 and SS41-SUS 405.
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