抄録
The localization of the receptors for estrogen (ER), epidermal growth factor (EGFR) and transferrin (TFR) was studied in 27 patients with prostatic carcinoma. The histological grade of the tumors was well differentiated in 7 cases, moderately differentiated in 10 cases and poorly differentiated in 10 cases. The antibodies used were commercially available monoclonal antisera to ER (Abbott), EGFR (Amersham) and TFR (Amersham). Five percent or more staining by the anti-ER antibody and 20% or more staining by the others was defined as positive.
ER expression was recognized in the nuclei of interstitial cells in 5 of the 27 cases, and 2 of these 5 also showed positive staining of tumor cell nuclei. This finding suggested that estrogen may have a direct effect on limited prostatic cancers. EGFR and TFR showed almost same staining patterns and positive rates (EGFR was 37%, and TFR was 52%). These receptors were expressed in the parabasal region of hypertrophic epithelium, and by all cell layers of the tumor cells in positive cases. Receptor expression tended to be more marked in poorly differentiated prostatic adenocarcinoma.
