1978 年 31 巻 9 号 p. 528-535
Pipemidic acid is a new antibacterial chemotherapeutic for oral use synthesized by Research and Development Piviiion of Dainippon Pharniaceutical Co., Ltd.(Japan), having pyridopyrirnidine, ringas basal structure similar to pkomidic acid.
This drug has an antibacterial spectrum chiefly against Gram-negative bacilli, and its characteristicis that the drug exhibits a strong antibacterial activity against, naliclixic acid- and piromidic acid-resistant bacteria, and its antibacterial activity is superior to carbenicillin against Pseudomonas deruskinosa.
The present authors have carried out the laboratory examinations withpipemidfc acid on its antibacterial activity, absorption, excretion and distribution, and the clinical evaluations of the drag have been performed on the urinary tract infections in the fields of internal medicine and urology
