1984 年 37 巻 7 号 p. 1321-1332
Miocamycin (MOM) is a derivative of midecamycin (MDM), a macrohde antibiotic isolated from a culture broth of Streptomyces mycarofaciens1, 2). Its chemical stmcture is shown in Fig. 1. It is reported that MOM has the most interesting antibacterial properties among the known macrohde antibiotics3, 4).
As previously reported on the acute toxicity of MOM in mice and rats5, 6), LD50 values in male and fbmale mice and rats after single intraperitoneal, subcutaneous and oral administration of MOM, non-crystalline solid, were estimated more than 5, 000mg/kg in all routes of administration without markedly toxic effects.
The oblective of this study was to examine toxicological effects of MOM, non-crystalline solid, in male and female rats after repeated oral administration for 5 weeks at selected dosage levels of 1, 000, 2, 000 and 4, 000mg/kg.
