1984 年 37 巻 7 号 p. 1333-1354
Miocamycin (MOM) is a derivative of midecamycin (MDM), a macrolide antibiotic isolated from a culture broth of Streptomyces mycarofaciens1, 2). Its chemical structure is shown in Fig. 1. It is reported that MOM has the most interesting antibacterial properties among macrolide antibiotics3, 4).
It has been known that MOM, non-crystalline solid, did not exhibit any noticeable toxic effects in male rabbits when it was orally administered once daily for 5 weeks at daily dosage levels of 100, 200 and 400mg/kg as previously studied in dose-finding studies. The objective of this study was to examine toxicological effects in male rabbits after repeated oral administration of MOM, non-crystalline solid, for 5 weeks at daily dosages of 400, 800, 1, 600 and 3, 200 mg/kg, which were selected for the studies in consideration of the results obtained from the dose-finding subacute toxicity studies in rabbits. The lowest dosage level of 400 mg/kg/day is corresponding to the highest dosage level of the dose-finding studies.
