TOXICOLOGICAL STUDIES ON A NEW MACROLIDE ANTIBIOTIC, MIDECAMYCIN ACETATE (MIOCAMYCIN)

CHRONIC TOXICITY IN RATS

抄録

Miocamycin (MOM) is a derivative of midecamycin (MDM), a macrolide antibiotic isolated from a culture broth of Streptomyces mycarofaciens1, 2). Its chemical structure is shown in Fig. 1. It is reported that MOM has the most interesting antibacterial properties among the known macrolide antibiotics3, 4). It has been known that the maximum tolerable dosage level of MOM, non-crystalline solid, was 1, 000 mg/kg in male and female rats when it was orally administered once daily for 5 weeks at daily dosage levels of 1, 000, 2, 000 and 4, 000 mg/kg as previously reported5).
The objective of this study was to examine toxicological effects in male and female rats after repeated oral administration of MOM, non-crystalline solid, for 26 weeks at daily dosage levels of 62. 5, 125, 250, 500 and 1, 000mg/kg.