PHARMACOLOGICAL EFFECTS OF CEFCLIDIN ON THE CENTRAL NERVOUS SYSTEM

TAKERU KANEKO; KANEMASA KATSU; MASATOSHI FUJIMOTO; HIROSHI YAMAUCHI; D. R. ALGATE; D. J. BEARD; C. M. JOBLING; P. L. MUNT

doi:10.11553/antibiotics1968b.46.18

TAKERU KANEKO, KANEMASA KATSU, MASATOSHI FUJIMOTO, HIROSHI YAMAUCHI, D. R. ALGATE, D. J. BEARD, C. M. JOBLING, P. L. MUNT

著者情報

ジャーナルフリー

1993 年 46 巻 1 号 p. 18-30

DOI https://doi.org/10.11553/antibiotics1968b.46.18

詳細

抄録

The effects of cefclidin (CFCL), a novel antibacterial agent, on the central nervous system (CNS) were examined in a variety of animal models. The effects of cefazolin (CEZ) were also examined for comparative purposes.
In the animal models used CFCL whilst having some effects at the doses examined, failed to show an overall consistent effect on the CNS.
In contrast CEZ produced changes in the parameters measured which were generally consistent with a proconvulsant ction.

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