Bioscience, Biotechnology, and Biochemistry
Online ISSN : 1347-6947
Print ISSN : 0916-8451
Biological Chemistry Notes
Biological Activities of (1→3)-β-D-Glucans with Reducing Glucose Side Chains
Tadashi KIHOMitsuhiro MATSUSHITAShigeyuki USUIShigeo UKAI
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1998 年 62 巻 3 号 p. 570-572

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  Newly synthesized (1→3)-β-D-glucans with reducing glucose side chains (6-O-glucopyranosylated curdlan and 3-O-glucopyranosylated curdlan, with glucose linked directly (except for anomeric carbon) had antitumor activity against mice sarcoma 180 in mice. The two glucans potentiated the reticuloendotheliai system and activated macrophages (increased their glucose consumption). The activity inducing tumor regressing factor of the glucan derivatives was stronger than a linear (1→3)-β-D-glucan (curdlan).
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© 1998 by Japan Society for Bioscience, Biotechnology, and Agrochemistry
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