Bioscience, Biotechnology, and Biochemistry
Online ISSN : 1347-6947
Print ISSN : 0916-8451
Biochemistry & Molecular Biology Notes
Synthesis of Anti-Tumor Dimeric Indole Alkaloids in Catharanthus roseus Was Promoted by Irradiation with Near-Ultraviolet Light at Low Temperature
Mamiko ASANOKazuo HARADATomoaki YOSHIKAWATakeshi BAMBAKazumasa HIRATA
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2010 Volume 74 Issue 2 Pages 386-389

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Abstract

We have found that coupling between catharanthine and vindoline occurs non-enzymatically in the presence of flavin mononucleotide and manganese ions with near-ultraviolet light irradiation in vitro. The present study found that the concentrations of catharanthine and vindoline in Catharanthus roseus decreased and those of dimeric indole alkaloids increased under near-ultraviolet light at 4 °C. It indicates that this coupling reaction at 4 °C occurs non-enzymatically.

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© 2010 by Japan Society for Bioscience, Biotechnology, and Agrochemistry
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