Sublethal Doses of Surfactants Induce Premature Senescence in Normal Human Skin Cells

Yoshimi YAMAKAMI; Kensuke MIKI; Morio ENDOH; Ryuzo YONEKURA; Ryo UKEKAWA; Yusuke KOBAYASHI; Michihiko FUJII; Dai AYUSAWA

doi:10.1271/bbb.110179

Biochemistry & Molecular Biology Notes

Sublethal Doses of Surfactants Induce Premature Senescence in Normal Human Skin Cells

Yoshimi YAMAKAMI, Kensuke MIKI, Morio ENDOH, Ryuzo YONEKURA, Ryo UKEKAWA, Yusuke KOBAYASHI, Michihiko FUJII, Dai AYUSAWA

著者情報

キーワード: human cells, cytotoxicity, detergent, cosmetics, senescence

ジャーナルフリー

2011 年 75 巻 7 号 p. 1395-1398

DOI https://doi.org/10.1271/bbb.110179

View "Advance Publication" version (July 7, 2011).

詳細

抄録

We evaluated the cytotoxicity of surfactants in human cells. Synthetic surfactants showed different cytotoxicity levels depending on their structures. The cytotoxicity of commercial washing products was determined mainly by the contents of surfactants. All of them induced premature senescence in normal cells, but not in tumor-derived or immortalized cells, under sublethal conditions. Residual surfactants might be a risk factor for skin aging.

責任著者(Corresponding author)

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