Construction of a Dominant Negative Form of Human Hypoxia-Inducible Factor-2α

Yasuki HIGASHIMURA; Ryoichi YAMAJI; Naoki HARADA; Motoyuki NAKAO; Yoshihisa NAKANO; Hiroshi INUI

doi:10.1271/bbb.100208

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Construction of a Dominant Negative Form of Human Hypoxia-Inducible Factor-2α

Yasuki HIGASHIMURA, Ryoichi YAMAJI, Naoki HARADA, Motoyuki NAKAO, Yoshihisa NAKANO, Hiroshi INUI

著者情報

キーワード: hypoxia-inducible factor-2α, dominant negative form, hypoxia-inducible factor-1α, hypoxia, hypoxia-inducible factor-1β

ジャーナルフリー早期公開

論文ID: 100208

DOI https://doi.org/10.1271/bbb.100208

この記事には本公開記事があります。

The final version of this article is now available: Vol. 74 (2010) , No. 10 p.2100

詳細

抄録

We constructed a dominant negative form of human hypoxia-inducible factor (HIF)-2α, HIF-2αDoN, which inhibited HIF transcriptional activity induced by hypoxia and by HIF-2α. HIF-2αDoN formed a complex with HIF-1β and interacted with DNA containing hypoxia response elements (HREs). Thus, the complex appears to inhibit the binding of HIF-2 to HREs, and HIF-2αDoN might provide a useful therapeutic tool for HIF-2α-related diseases.

責任著者(Corresponding author)

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