Inhibitory Effects of Bakuchiol, Bavachin, and Isobavachalcone Isolated from Piper longum on Melanin Production in B16 Mouse Melanoma Cells

Osamu OHNO; Taeko WATABE; Kazuhiko NAKAMURA; Masaru KAWAGOSHI; Nobuo UOTSU; Tomohiro CHIBA; Masayoshi YAMADA; Kohji YAMAGUCHI; Kaoru YAMADA; Kenji MIYAMOTO; Daisuke UEMURA

doi:10.1271/bbb.100221

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Inhibitory Effects of Bakuchiol, Bavachin, and Isobavachalcone Isolated from Piper longum on Melanin Production in B16 Mouse Melanoma Cells

Osamu OHNO, Taeko WATABE, Kazuhiko NAKAMURA, Masaru KAWAGOSHI, Nobuo UOTSU, Tomohiro CHIBA, Masayoshi YAMADA, Kohji YAMAGUCHI, Kaoru YAMADA, Kenji MIYAMOTO, Daisuke UEMURA

著者情報

キーワード: melanin, Piper longum, bakuchiol, bavachin, isobavachalcone

ジャーナルフリー早期公開

論文ID: 100221

DOI https://doi.org/10.1271/bbb.100221

この記事には本公開記事があります。

The final version of this article is now available: Vol. 74 (2010) , No. 7 p.1504

詳細

抄録

An EtOH extract of fruits of Piper longum was found to exhibit a potent inhibitory effect against α-melanocyte-stimulating hormone (α-MSH)-induced melanin production in B16 mouse melanoma cells. Bioassay-directed fractionation led to the isolation of prenylated phenolic compounds bakuchiol, bavachin, and isobavachalcone. These compounds and the crude extract of the fruits of P. longum may have suppressive effects against pigmentation by melanin in the skin.

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